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Revisit of typical counterclockwise atrial flutter wave in the ECG: electroanatomic studies on the determinants of the morphology
Get PDF弘前大学博士（医学）掲載誌 P.A.C.E. : pacing and clinical electrophysiology, 36, p.978-87, 201
Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer
Get PDF弘前大学博士（医学）掲載誌 Oncotarget
, 8, p.61404-61414, 201
Dual Energy CTを用いた正常乳腺組織と腫瘍組織の評価
Get PDF弘前大学博士（保健学）The present study aimed to investigate the possibility of using dual-energy computed tomography (DECT) before therapy to discriminate between normal breast tissue and tumor tissue in patients with breast cancer, without the need to use a contrast medium. The following patient data were extracted by interview and from the hospital’s radiology information system: height, weight, age, menstrual cycle, CT images of normal tissue and tumors with or without contrast medium, and the histopathological diagnosis of the core needle biopsy. The median age of the 43 participants was 56 years (range, 30 -80 years). The CT values were evaluated using a clinical analytical program based on the three-material decomposition technique. Breast cancer was classified into ductal carcinoma in situ, invasive ductal carcinoma, invasive lobular carcinoma, fibromatosis-like metaplastic carcinoma, and apocrine carcinoma. In all conditions, regardless of contrast medium, the CT values of tumor tissues were higher than those of normal breast tissue, indicating the effectiveness of DECT in the diagnosis of breast cancer. By contrast, DECT showed limited potential for distinguishing ductal carcinoma in situ from invasive ductal carcinoma. There have only been a few reports regarding CT examination of breast cancer, and it is expected this study encourages the development of DECT imaging to improve tumor detection in patients with breast cancer
自然放射線被ばく研究を活用したリスクコミュニケーション手法の確立に関する研究
Get PDF弘前大学博士（保健学）On 11 March 2011, a 9.0 magnitude earthquake, which occurred at Northern Japan, and subsequent tsunami caused serious damage to the Fukushima Daiichi Nuclear Power Station (FDNPS). People living within a radius of 30 km evacuated from their homes. Residents at Namie Town stayed at Tsushima district, which was located in the northwest of the FDNPS. As a highly concentrated radioactive plume passed through this area however, the evacuees werevery much worried about their radiation doses and internal exposures. In order to overcome this anxiety, public people should recognize more detailed knowledge about natural radiation exposure. There are several high back ground radiation areas (HBRAs) in the world. Residents living in these areas have been exposed to low dose radiation over a long term. Chapter 1 mainly describes the aim of the present study. The motivation and background as well. Chapter 2 describes the recognition of radiation among general public in Namie Town and Aomori Prefecture (Hirosaki, Aomori and Hachinohe Cities). The survey was carried out using anonymous questionnaires. According to the data analysis, people recognized that they were exposed to natural radiations of more than 1 mSv. However, people in Namie Town thought even radiation of 1 mSv would cause some biological effects. In addition, many people recognized that there would be differences in health effects between artificial and natural radiations, internal and external exposures, respectively. In particular, residents of Namie Town concerned about their own internal exposures by ingestion of food and water. Chapter 3 focuses on internal exposures caused by inhalation of radon and thoron progeny because the internal exposures have not yet been clarified in HBRAs. For their dose assessment, radon, thoron and thoron progeny concentrations were measured by passive monitors over a long period. Consequently, annual effective doses are estimated to be 3.1 ± 2.0 mSv for radon and 2.2 ± 2.5 mSv for thoron respectively. Total dose are estimated to be 5.3 ± 3.5 mSv a-1. The present study has revealed that the radon dose was comparable than the thoron dose, and the total dose was about 2 times higher than the worldwide average. Chapter 4 summarized the present study. The conclusion is obtained as follows: In order to improve radiation risk communication, it is necessary to explain the health risk due to low dose chronic exposure clearly to general public using new scientific findings in HBRAs studies. For instance internal exposures due to inhalation of radon and thoron progeny are unavoidable for general public. It implies that the strategy may be effective for further understanding of radiation risk
Significance of serum N-glycan profiling as a diagnostic biomarker in urothelial carcinoma
Get PDF弘前大学博士（医学）掲載誌 European Urology Focus S2405-4569(16)30162-
Safety and efficacy of contemporary catheter ablation for atrial fibrillation patients with a history of cardioembolic stroke in the era of direct oral anticoagulants
Get PDF弘前大学博士（医学）掲載誌 Journal of Cardiology, 70, p.86-91, 201
High Osteogenic Potential of Adipose- and Muscle-derived Mesenchymal Stem Cells in Spinal-Ossification Model Mice
Get PDF弘前大学博士（医学）掲載誌 Spine, 42, E1342-E1349, 201