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Analysis of lumbar and pelvic girdle pain in pregnant women： Relationship among childbirth, onset of lower back pain, and health-related quality of life in female patients with lower back pain：a retrospective Study Factors associated with the degree of sexual disability in patients with postpartum low back pain Effects of physical therapy on postpartum low back pain patients in the puerperium
Get PDF弘前大学博士（保健学）学位論文のもととなる研究成果としての筆頭著者原著
論文題目：Relationship among Childbirth, Onset of Lower Back Pain, and Health-Related Quality of Life in Female Patients with Lower Back Pain: A Retrospective Study
掲載学術誌（巻号）：Spine Surgery and Related Research (2024 Volume 8 Issue 5 Pages 528-533)
DOI：https://doi.org/10.22603/ssrr.2023-0295学位論文のもととなる研究成果としての筆頭著者原著
論文題目：産褥期の産後腰痛患者に対する理学療法の効果
掲載学術誌（巻号）：Journal of Spine Research（2024 年 15 巻 6 号 p. 885-892）
DOI：https://doi.org/10.34371/jspineres.2024-0612学位論文のもととなる研究成果としての筆頭著者原著
論文題目：産後腰痛患者の性生活障害度に関連する因子
掲載学術誌（巻号）：ウィメンズヘルス・メンズヘルス理学療法学 第 2 巻，10 ～ 15，2025
DOI：https://doi.org/10.69171/jwhmhpt.jwhmhpt20240
Utility of circulating human papillomavirus DNA as a biomarker for detection and prognosis of cervical cancer in Japanese patients
No full textBackground
Cervical cancer (CC), the fourth most common cancer in women, is caused predominantly by human papillomavirus (HPV). Although measuring serum squamous cell carcinoma antigen (SCC Ag) can be useful for detecting recurrence of SCC, a major type of CC, its prognostic value remains unclear. This study focuses on the utility of circulating cell-free HPV (ccfHPV) DNA in plasma as a biomarker, with particular emphasis on its relevance to high-risk HPV subtypes prevalent in Japan.
Methods
A prospective study of 26 CC patients and 23 females diagnosed with pre-cancerous lesions was conducted. Patients were selected carefully to include only those with single high-risk HPV subtypes (i.e., HPV16, 18, 52, or 58), reflecting regional HPV epidemiology. ccfHPV DNA was isolated from plasma and analyzed by droplet digital PCR targeting the HPV E7 genes.
Results
The detection rate of ccfHPV DNA in CC patients before clinical treatment was 57.7%. The detection rate correlated significantly with tumor size (r = 0.624, P < 0.01) and clinical stage (r = 0.844, P < 0.01). No ccfHPV DNA was detected in the females with pre-cancerous lesions. By contrast, of the 13 concurrent chemoradiotherapy cases, two relapsed within 6 months post-treatment. In those cases, ccfHPV DNA levels rose earlier than SCC Ag levels. The 11 CC cases in which no ccfHPV DNA was detected within 1 month post-treatment did not relapse.
Conclusion
ccfHPV DNA is a useful biomarker for advanced-stage CC and for predicting prognosis, particularly in the Japanese clinical setting.弘前大学博士（医学）Author(s): Taguchi, Tomoko ; Yokoyama, Minako ; Fujita, Toshitsugu ; Tanba, Satoka ; Oikiri, Hiroe ; Osawa, Yuki ; Matsumura, Yukiko ; Shigeto, Tatsuhiko ; Yokoyama , Yoshihito ; Fujii, Hodak
Factors Affecting Outcomes of Poor-Grade Subarachnoid Hemorrhage
No full textObjective
Poor-grade subarachnoid hemorrhage (SAH) accounts for 20% of all SAH and is associated with poor outcomes. The first step in improving outcomes is to analyze the factors that contribute to poor outcomes.
Methods
This was a multicenter, retrospective, observational, cohort study. Data fields included demographic, clinical, radiological, and outcome data for all spontaneous patients with SAH treated at 4 hospitals in Aomori Prefecture in Japan. Patients with modified Rankin Scale score 0–2 at discharge were defined as the good outcome group, and those with modified Rankin Scale score 3–6 were defined as the poor outcome group, and comparisons were made between the 2 groups.
Results
There were 329 eligible patients with poor-grade SAH, 41 with good outcome group, and 288 with poor outcome group. On multivariate analysis of the outcome, conservative treatment (P < 0.001), Fisher group 4 (P < 0.007), age ≥65 years (P = 0.011), and Hunt and Kosnik grade V on admission (P = 0.021) were significant factors contributing to a poor outcome.
Conclusions
Nonelderly patients who are not in grade V and Fisher group 4 should undergo aneurysm treatment as soon as possible because they are more likely to have a good outcome, whereas elderly patients in grade V and Fisher group 4 are unlikely to benefit from aneurysm treatment at present. The development of a treatment for early brain injury may be important to improve the outcomes of patients with poor-grade SAH.弘前大学博士（医学）Author: Sasaki, Takao ; Naraoka, Masato ; Shimamura, Norihito ; Takemura, Atsuto ; Hasegawa, Seiko ; Akasaka, Kennichi ; Ohkuma, Hirok
Integrated gross and microanatomical analysis of the periportal lymphatic system in human liver
No full textBackground
Although animal studies have indicated that the periportal lymphatic system is an important intrahepatic lymphatic route, detailed human studies are scarce. We studied the lymphatic pathways and dynamics around Glisson's capsule in human livers.
Methods
We performed whole-mount immunostaining for the liver using podoplanin and CD-31 to elucidate the lymphatic vessel distribution around the hepatic triad (HT). Next, 5 mL of India ink was injected into the liver parenchyma to observe the lymph fluid dynamics around Glisson's capsule. Lastly, immunohistochemical staining for CCL21, a chemokine important for lymphocyte migration, and its receptor CCR7 was performed to observe the lymphocyte dynamics within Glisson's capsule.
Results
Lymphatic vessels with blind-ended structures were observed around the peripheral HT. These vessels ran longitudinally, forming a network with numerous blind ends around HT. Ink distribution was observed within gaps and capillary lymphatic vessels in Glisson's capsule. These gaps were CCL21-positive, and a concentration gradient was observed toward the capillary lymphatic vessels.
Conclusions
The intrahepatic lymphatic fluid enters the capillary lymphatic vessels via the extravascular pathway, and lymphocyte components enter the capillary lymphatic vessels through the CCR7/CCL21 transport system in the extravascular pathway. This is the first study to elucidate the human intrahepatic periportal lymphatic system.弘前大学博士（医学）Author(s): Mitsuhashi, Yuto ; Shimoda, Hiroshi ; Umemura, Kotaro ; Kagiya, Takuji ; Sato, Kentaro ; Narita, Hirokazu ; Chiba, Tomohiro ; Ishido, Keinosuke ; Kimura, Norihisa ; Hakamada, Kenich
Medium-and Long-term Development of Social Innovation ― Through relationships With stakeholders ―
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Research on Postoperative Scar Quality of Sutures and Skin Surface Adhesives
Get PDFObjectives: This study aimed to compare the quality of scarring of DERMABOND PRINEO (Ethicon, Inc., Somerville, NJ, USA)Ⓡ by conducting a half-side test on the same wound to determine its superiority. If the utility of DERMABOND PRINEOⓇ is established, its use can be expanded for more cases and higher quality medical care can be provided.
Methods: Patients who underwent two-stage breast reconstruction were included. The first surgery was half closed with DERMABOND PRINEOⓇ and nylon threads, and the time was measured. At the second surgery, all scars were removed, and a histopathological examination was done. Scars were evaluated with the Vancouver Scar Scale (VSS) and visual analogue scale (VAS), and statistical analysis was performed.
Results: Time to closure was significantly shorter in the DERMABOND PRINEOⓇ group. Postoperative VSS scores for pliability were significantly lower in the suture group, and the total VSS score was significantly lower in the suture group from 3 to 6 months postoperatively. Patients rated postoperative wound pain, itching, appearance, and satisfaction with the VAS, but no significant differences were observed between the two groups. The scars were compared with hematoxylin-eosin staining and Elastica van Gieson staining. Differences were seen in the increase of elastic fibers in the dermal reticular layer, a characteristic difference between the two groups.
Conclusions: The use of DERMABOND PRINEOⓇ leads to a reduction in operative time and impacts the maturity of the scar. It is expected that the indications for DERMABOND PRINEOⓇ can be further expanded in the future.弘前大学博士（医学
Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol
Get PDFAim: We aimed to create a rat model of drug-induced parkinsonism and tardive dyskinesia by chronic administration of haloperidol and examine the expression of direct and indirect pathway markers in the striatum of the model rats.
Methods: We treated 21 rats, 14 with haloperidol decanoate and 7 with placebo. The number of vacuous chewing movements per 2 min was counted, and haloperidol-treated rats were classified into two groups: mild and severe tardive dyskinesia. Other behavioral analyses were also conducted. After a 6-month treatment period, rat brains were removed, and protein expression was evaluated by Western blotting.
Results: All haloperidol-treated rats exhibited vacuous chewing movements. The frequency of exploratory behavior and rotarod test performance was lower in the mild and severe tardive dyskinesia groups. The number of vacuous chewing movements and frequency of exploratory behavior were positively correlated in haloperidol-treated rats. The expression of dynorphin, a direct pathway marker, decreased in the severe tardive dyskinesia group. The expression of enkephalin, an indirect pathway marker, decreased both in the mild and severe tardive dyskinesia groups. The expression of dopamine D1 and D2 receptors also decreased with haloperidol treatment.
Conclusion: Both direct and indirect pathways are involved in haloperidol-induced movement disorders.弘前大学博士（医学）Author(s): Iku Kinoshita, Haruo Nishijima, Takashi Nakamura, Tomoya Kon, Shuji Shimoyama, Hiroki Hikichi, Chieko Suzuki, Masahiko Tomiyama
Neuropsychopharmacology Reports, 2025; 45:e1252
Evaluating the efficacy of the punch-out technique in systemic-to-pulmonary shunts: A computational fluid dynamics approach
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Research on spatial recognition ability necessary for driving with the aim of applying to stroke patients - Verification using Virtual Reality -
Get PDF弘前大学博士（保健学）学位論文のもととなる研究成果としての筆頭著者原著
論文題目：Verification of spatial recognition ability of stroke patients required to resume automobile driving
掲載学術誌（巻号）：Journal of Physical Therapy Science (2021 Volume 33 Issue 6 Pages 455-459)
DOI：https://doi.org/10.1589/jpts.33.45