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Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma
Get PDF弘前大学博士（医学）掲載誌：Pathology Journal 2024 Feb;56(1):65-74., Epub 2023 Nov 21
Utility of the Age Discrepancy between Frailty-Based Biological Age and Expected Life Age in Patients with Urological Cancers
Get PDF弘前大学博士（医学）掲載誌：Cancers 2022 Dec 17;14(24):6229
Clinical Benefits of Oral Anticoagulants for Elderly Patients With Cardioembolic Stroke at High Bleeding Risk
Get PDF弘前大学博士（医学）掲載誌：In Vivo 2024 Mar-Apr;38(2):725-73
Serum 3-Hydroxybutyrate is Expected to Serve as One of the Supportive Diagnostic Markers of Persistent Idiopathic Dentoalveolar Pain (PDAP)
Get PDFBackground: Persistent idiopathic dentoalveolar pain (PDAP), previously referred to as atypical odontalgia, is a chronic dental pain that occurs without signs of pathology. PDAP is considered a diagnosis of exclusion, and its definition is currently under refinement and remains ambiguous. The metabolite known as 3-hydroxybutyrate (3HB) has garnered significant interest as a potential indicator for both depression and chronic psychogenic pain. We investigated the characteristics of patients with PDAP and hypothesized that serum 3HB could support the diagnosis of PDAP.
Subjects and Methods: Forty-one patients with PDAP and 167 patients with odontogenic toothache were investigated regarding depression and anxiety scales in addition to the general dental evaluation. Blood tests including high-sensitivity CRP, HbA1c, and 3HB were performed for all patients. Associations between PDAP and patients’ varying characteristics were investigated using hierarchical multivariate logistic regression analyses.
Results: There were more females, current smokers, patients with orofacial pain (such as temporomandibular joint pain, glossalgia, and headache), and people with elevated 3HB levels among patients with PDAP than among control participants. Multivariate logistic regression analyses predicting patients with PDAP identified the female sex (odds ratio [OR]: 4.16), current smoking (OR: 14.9), glossalgia (OR: 19.8) a high CES-D score (≥16) (OR: 5.98), and elevated serum 3HB (≥80 μmol/L) (OR: 18.4) factors significantly associated with PDAP.
Conclusion: Our results demonstrated that serum 3HB levels could be elevated in patients with PDAP compared to other types of odontogenic pain, although 3HB was not specific to PDAP. Based on our findings, five factors - female sex, current smoking, depressive tendencies, chronic orofacial pains, and high serum 3HB levels - could be useful for diagnosing PDAP.弘前大学博士（医学）Author: Katsuya Tamaki, Norihiro Saito, Hirofumi TomitaCitation: Journal of Pain Research :16:4005-4013, 2023 Nov 2
A Longitudinal Study of CogEvo's Prediction of Cognitive Decline in Older Adults
Get PDFThe predictive abilities of computer-based screening devices for early cognitive decline (CD) in older adults have rarely been longitudinally examined. Therefore, this study examined the ability of CogEvo, a short-duration, computer-based cognitive screening device requiring little professional involvement, to predict CD among community-dwelling older adults. We determined whether 119 individuals aged ≥ 65 years living in Japanese rural communities who scored ≥ 24 on the Mini-Mental State Examination (MMSE) at baseline developed CD by annually administering the MMSE to them. CD was defined as an MMSE score of ≤23. At baseline, the overall CogEvo judgment grade, with lower grades indicating better cognitive function, was calculated from the results of various cognitive tasks. Over 2 years, 10 participants developed CD. Participants with grades of 4 had a higher percentage of CD cases than those with grades of ≤3 (p < 0.01). This relationship remained significant after controlling for possible confounders, including the MMSE score at baseline. The sensitivity and specificity of the CogEvo grade cutoff of 4 were 50.0% and 93.6%, respectively. In conclusion, CogEvo may be an efficient tool for identifying individuals at a high risk for dementia. The possibility of missing CD cases should be considered when using CogEvo for screening.弘前大学博士（医学）Author: Sadanobu Ichii, Hikaru Oba, Yoshikuni Sugimura, Yichi Yang, Mikio Shoji, Kazushige IharaCitation: Healthcare, 12(14):1379, 2024 Jul 1
Seismic relative displacement of two blocks of different construction ages across an expansion joint
Get PDF弘前大学修士（地域共創工学
The new 222-nm far ultraviolet-C lowers bacterial contamination to endoscopists during esophagogastroduodenoscopy
Get PDF弘前大学博士（医学）掲載誌：DEN Open 2023 Sep 12;4(1):e292, eCollection 2024 Apr
The Relationship between Serum Adiponectin, Urinary Albumin/Creatinine Ratio and Type 2 Diabetes: A Population-Based Cross-Sectional Study
Get PDF弘前大学博士（医学）掲載誌：Journal of Clinical Medicine 2022 Dec 5;11(23):723