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How to enhance readiness for advance care planning among community-dwelling older adults: A scoping review
No full textPurpose: 1.Comprehensively identify and collate interventions designed and implemented across diverse settings—including communities and healthcare institutions—to enhance older adults' advance care planning readiness. These interventions address dimensions such as knowledge, attitudes, willingness to communicate, and behavioural intentions.
2. Conduct a detailed analysis and categorisation of the core characteristics of these interventions, including but not limited to their theoretical frameworks (such as the Health Belief Model, the Trans-Theoretical Model, mindfulness, etc.), intervention content and formats (such as educational programmes, decision-support tools, family conferences, psychological interventions, etc.), implementation methods and contexts (implementers, duration, frequency, settings), and the characteristics of the target populations (such as healthy older adults, individuals with chronic conditions, patients in the terminal stages of illness, etc.).
Expected outcomes: Present the primary intervention pathways for enhancing advance care planning readiness among older adults in a visual format, such as charts or categorised frameworks (e.g., education-empowerment approaches, communication-facilitation approaches, psychological counselling approaches, decision-support approaches, and integrated multi-component approaches). Clarify the representative methods, core components, and applicable scenarios for each strategy.
The inclusion criteria for this scoping review were based on the population, concept, and context (PCC) :(1) Population: older adults (age≥50 years old. This age selection is due to the shift in primary care focus towards chronic disease and cancer screening at this stage, providing healthy older adults with an opportunity to engage in ACP.); (2) Concept: This review focuses on intervention strategies to enhance older adults’ readiness for advance healthcare directives and their associated outcomes; (3) Context: Community; (4) Types of evidence: The studies included were full-length systematic studies published whose methods were quantitative, qualitative, or mixed-methods design
Immune Resonance in Rheumatoid Arthritis — A Systems Model of T–B Cell Synchronization and Therapeutic Implications
No full textThis work presents a structural model for chronic inflammatory diseases, using rheumatoid arthritis as the primary example.
The model defines disease expression as the interaction of intrinsic factors, external synchronizing stimuli, and individual susceptibility, formalized through a mathematical framework integrating immune pathways, cytokine modes, and B‑cell clonal dynamics.
This framework resolves long‑standing clinical contradictions such as MTX non‑response, relapse after biologics withdrawal, and heterogeneous disease courses.
The model is developed as an applied extension of a broader resonance‑based theoretical framework, adapted here to describe the structural dynamics of chronic inflammation.
Although rheumatoid arthritis is used as the central case, the structure is generalizable to a wide range of chronic diseases
Avaliando o impacto de conflitos de interesses, práticas de pesquisa questionáveis e spin nos resultados de ensaios clínicos de psicoterapia brasileiros
No full textConflitos de interesses (CDIs) financeiros em ensaios clínicos randomizados (ECRs) geram um viés sistemático, direcionando resultados e conclusões aos interesses dos autores ou financiadores. Evidências sugerem que este viés pode ser introduzido por meio de práticas de pesquisa questionáveis (PPQs) e spin (viés de relato de resultados). CDIs financeiros comumente presentes em ECRs de psicoterapia, como a venda de licenças para uso da intervenção ou materiais e treinamentos exclusivos para seu uso, são pouco acessíveis e pouco investigados, tornando seus impactos incertos. No entanto, as atuais evidências sugerem que a eficácia de tratamentos psicoterápicos esteja inflacionada devido à presença de ECRs suscetíveis a vieses, além de altas taxas de PPQs e spin, sugerindo um potencial impacto de CDIs financeiros em ECRs de psicoterapia, prejudicando os resultados de revisões sistemáticas e meta-análises. Este cenário pode comprometer a tomada de decisão de profissionais de saúde e formuladores de políticas públicas acerca do alocamento de tratamentos adequados para diversos transtornos mentais.
OBJETIVO: Avaliar a influência de CDIs financeiros, PPQs e spin nos resultados reportados de ensaios clínicos randomizados brasileiros que testaram intervenções psicoterápicas para transtornos mentais.
MÉTODOS: Foi desenvolvido um protocolo para identificar, categorizar e quantificar (1) CDIs financeiros; (2) PPQs e (3) spin em ECRs de psicoterapia. Este protocolo será pré-registrado no Open Science Framework (OSF) antes da coleta de dados e todo o material, bancos de dados e os códigos para análise estatística serão abertamente acessíveis. Para (1), uma lista de 11 potenciais CDIs financeiros foi elaborada com base nas diretrizes da ICMJE e COPE. Para cada ECR incluído, os potenciais CDIs financeiros de seus autores serão obtidos através de uma pesquisa em plataformas de domínio público disponíveis e indexadas na web, auxiliada pela ferramenta de IA Deep Research do Google Gemini. Os CDIs serão coletados considerando todos os autores presentes no artigo, resultando em uma soma total de CDIs para cada ECR. Para cada item, também será extraído: (a) se o CDI foi relatado no ECR (pontuação dicotômica, 1=sim e 0=não) e (b) se o CDI é atribuído ao primeiro ou último autor (pontuação dicotômica, 1=sim e 0=não). Para (2), será utilizada uma versão adaptada da estratégia elaborada por Damen et al. (2023) 24 . Esta estratégia se baseia no uso de instrumentos análogos à PPQs, gerando uma pontuação estimada acerca da presença de PPQs em determinado estudo. Serão investigados (a) o risco de viés, através da ferramenta risk-of-bias tool 2 da Cochrane (RoB2), (b) o relato seletivo de resultados, investigado pela discrepância entre o desfecho principal relatado no artigo e seu registro prospectivo (quando houver), (c) o poder estatístico, calculado através da razão entre o número de participantes do estudo versus o número de participantes necessários de acordo com o cálculo do tamanho da amostra presente no registro; e (d) o viés de relato estatístico, estimado através da comparação entre o valor p relatado na publicação com o valor p real da estimativa do tamanho de efeito da intervenção. Para (3), foi elaborada uma lista de 23 itens de spin com base na literatura do tema 25,26 , que serão examinados no resumo e texto principal dos estudos. Os artigos serão avaliados por 2 revisores independentes, utilizando um formulário pré-definido. Discrepâncias serão discutidas entre os autores, com a intervenção de um terceiro revisor, caso necessário. Os ECRs de psicoterapia brasileiros serão extraídos de 4 bancos de dados de meta-análises de depressão e ansiedade, que são atualizados anualmente e disponibilizados para livre acesso no site metapsy.org. Os ECRs serão filtrados por região à fim de identificar os ECRs conduzidos em território brasileiro. Também serão realizadas buscas em bancos de dados de pré-registros de ECRs, como clinicaltrials.gov e ensaiosclinicos.gov.br.
ANÁLISE: Será utilizado o software R (versão 4.5.0). Taxas de CDIs financeiros, PPQs e spin serão obtidas através de análises descritivas, com sua adequação investigada por meio de critério pré-estabelecido: alta (≥ 75%), moderada (50–74%), baixa (25–49%) e mínima (< 25%). As associações entre CDIs financeiros com taxas de PPQs e spin serão investigadas por meio de modelos de regressão linear. O impacto de CDIs financeiros no tamanho dos efeitos dos estudos será investigado através de uma meta-regressão
SCOPUS DATA RELATED TO AI INTEGRATION IN MATHEMATICS EDUCATION FOR BIBLIOMETRIC ANALYSIS
No full textThis project is a collection of publicly available scholarly data from Scopus database that are related to AI integration in mathematics education from January 2015 to June 2025
Nurse Practitioner Care for Hospitalized Children: A Scoping Review Protocol
No full textThis scoping review will synthesize international literature on nurse practitioner (NP) roles in pediatric inpatient medicine settings, identifying key determinants of NP role implementation. Guided by the PEPPA framework, this review will examine implementation strategies, outcomes, timelines, facilitators, barriers, and required resources to inform future integration and evaluatio
promptfluid® Substrate v3.11- Cognitive OS for Autonomous AI Systems
No full textpromptfluid® Substrate v3.11 is a Cognitive OS for autonomous AI systems.
The Substrate provides cognitive primitives - memory, reflection, intent decoding, multi-provider routing, observability, security, and dream processing, all exposed through a unified cognitive API.
This architecture enables autonomous systems to compose cognition as software without binding to monolithic agent abstractions.
v3.11 includes the Module Actions Registry, Developer Manual, User Manual, and Substrate Changelog and more. Refer to the original substrate post for v1 docs
Brand Development Strategies for Businesses in the Digital Era
No full textBrand development in the current digital age can be even more complex, given the increasing number of technological advancements, use of digital media, and changes in consumer behavior. Today, organizations are not judged by the product/services they offer, but digital presence, digital communication, and brand experience are some important factors that determine how the customers perceive them. Brand development, therefore, can be an important function that affects competition, trust, and business sustainability. The article will analyze brand development for businesses operating under the digital environment, with a focus on the conceptual as well as practical approaches. The paper will not present any new theory or findings but will try to compile existing brand building concepts into something that will fit the actual digital market environment. The paper will discuss general concepts for digital brand building along with brand purpose, identity, engaging audiences, content-based communication, brand building, along with consistency on multiple digital channels. Furthermore, the article identifies some Typical Challenges that businesses experience concerning digital brand building. These include building a cohesive brand identity, digital reputation management, and adapting to the ever-changing digital trends. Through the provision of a defined and useful framework, the current research study hopes to aid businesses, especially small to medium-sized enterprises, in establishing robust, authentic, and loyal brands. The results of the research underpin the fact that sound digital brand building is subject to strategic planning, adaptation, and a match between the internal identity of the organization and the digital brand communication
FRAMFOW - Moral messaging and food wasting behaviour
No full textThis project examines how moral communication influences attitudes and intentions regarding food wasting. In a nine-condition experiment (seven moral video messages vs. one non-moral control video message vs. no video control), we measure attitudes, behavioural intentions, emotions, and policy support. We expect moral framings to reduce tolerance for food wasting and increase support for food-saving behaviours, offering both theoretical insights into moral psychology and practical guidance for public campaigns