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Intersecting pathways: The overlap between cerebral palsy and co-occurring neurodevelopmental conditions
No full textThis narrative review will synthesize evidence on the critical, and often under-recognized, overlap between cerebral palsy (CP) and co-occurring neurodevelopmental disorders (NDDs), particularly autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD).
Although CP has traditionally been conceptualized primarily as a motor disorder, a growing body of research indicates that NDDs frequently co-occur, contributing to the complexity of assessment, diagnosis, and long-term management. Understanding this overlap is essential for developing more accurate, tailored and faster diagnostic pathways and delivering integrated, multidisciplinary care.
This review will synthesize available evidence on:
a. Descriptive characteristics of the overlap, including the prevalence of NDDs in individuals with CP, differences across CP subtypes, shared etiological factors, and variations in age of diagnosis.
b. Diagnostic challenges arising from the overlap, such as symptom similarity, diagnostic overshadowing, and the limitations of current assessment tools in accommodating multi-level impairments.
c. Impact of the overlap on functioning, including mapping the domains of functioning (according the International Classification of Functioning, Disability and Health; ICF) affected by this co-occurrence and examining whether this co-occurrence reflects a sum of the conditions or whether it represents a distinct phenotype.
d. Future directions for improving care, including clinical, research, and broader societal implications
Safety of particle therapy versus photon stereotactic body radiotherapy (SBRT) for lung cancer with interstitial lung disease (ILD): a systematic review and meta-analysis
No full textPatients with early-stage lung cancer complicated by ILD are at substantially increased risk of radiation-related lung toxicity, including severe radiation pneumonitis (RP) and acute exacerbation of ILD. Although photon SBRT is widely used, its safety in patients with ILD remains uncertain and is largely based on small, single-center retrospective studies. While particle therapy (proton or carbon-ion) offers theoretical dosimetric advantages that could reduce the low-dose lung volume, there is limited and inconsistent clinical evidence. There are currently no studies that directly compare particle therapy and SBRT based on the same eligibility criteria. This systematic review collects and quantitatively integrates toxicity and survival outcomes from studies published since 2010. The aim is to clarify the relative safety of particle therapy and to identify candidate parameters to guide clinical selection and future trials
Benefits of blood product administration in major trauma victims in prehospital care: scoping review
No full textIntroduction: Trauma is a global public health problem, with a high mortality rate and decreased quality of life. In victims of major trauma, hemorrhagic shock represents one of the main causes of death in prehospital settings, highlighting the importance of administering blood products.
Objective: To map the benefits of administering blood products to victims of major trauma in prehospital settings
Targeted Attention Improves Human Classification of AI-Generated and Real Faces: Insights from Eye Movements and Deep Learning Models
No full textPilot Study: Validation of the Veterinary Wound Classification Matrix (CVH-RPE)
No full textValidation of a novel triage tool for canine and feline traumatic wounds. The CVH-RPE Matrix classifies injuries based on Anatomical Region (R), Structural Depth (P), and Systemic Extension (E) to standardize therapeutic decision-making
Traditional Buddhist Mindfulness versus Secular Mindfulness-based Cognitive Therapy for Residual Depressive Symptoms in Patients Treated for Depressive Disorder
No full textIn this pilot randomized controlled trial, Buddhist adults with residual depressive symptoms (Beck Depression Inventory–II [BDI-II] score >13) receiving outpatient antidepressant treatment were randomized to an 8-week group-based TBM or MBCT intervention. Primary outcomes were depressive symptoms (BDI-II) and psychological wellbeing (WHO-5 Well-Being Index). Secondary outcomes included mindfulness, self-compassion, and perceived benefits from religiosity/spirituality. Primary analyses followed the intention-to-treat principle. Non-inferiority margins were prespecified at 2.5 BDI-II points and 1.25 WHO-5 points
Neuromorphic Isomorphism: A Silicon Dendrite Framework for Simulating Neurological Pathology and Neurodegenerative Decay
No full textCurrent computational neurology relies on software simulations running on Von Neumann
architectures, which lack the physical fidelity to model the spatiotemporal dynamics of
neurodegeneration. Building upon the "Silicon Dendrite Unit" (SDU) architecture, we propose a
novel framework of Neuromorphic Isomorphism. By mapping the cable theory of biological
dendrites directly onto analog CMOS-memristive circuits, we derive a hardware-level transfer
function for modeling neurotransmitter kinetics. We specifically demonstrate how the tunable
resistance drift of memristors can simulate the dopaminergic decay characteristic of Parkinson’s
disease. Our results indicate that this "Pal-Dendrite" architecture can model pathological states
with <50 fJ per synaptic event, providing a rigorous physical substrate for next-generation
electronic medicine and implantable neuro-prosthetics
Impression Management Study 1
No full textThis study investigates whether brief exposure to different impression-management styles (neutral self-presentation, straight bragging, or humblebragging) influences how people subsequently present themselves in an evaluative context. Building on theories of social contagion and norm learning, we test whether observing inauthentic or strategic self-presentation norms affects (a) the authenticity of participants’ own self-presentation and (b) their meta-perception accuracy (the alignment between how they think they are evaluated and how independent observers evaluate them)
Trends in the Etiology and Clinical Characteristics of Biliary Osbtruction: A Large-Scale, Single-Center Study
No full textThe etiological and clinical landscape of biliary obstruction is presumed to evolve over time; however, long-term, large-scale data to substantiate these changes are limited. This study aims to conduct a comprehensive investigation into the temporal trends in the etiology, demographics, and key diagnostic characteristics of biliary obstruction over a 16-year period (2008-2023) at a major tertiary medical center.
This research will be conducted as a large-scale, retrospective, single-center study. The study population will be drawn from patients who were diagnosed with biliary obstruction between January 2008 and December 2023. From an initial cohort of patients with a clinical diagnosis, a subset of patients who received a definitive pathological diagnosis will be included for the primary etiological analysis, ensuring the robustness of the data.
The core analysis will focus on several key research questions:
How has the proportion of malignant versus benign etiologies of biliary obstruction changed over the 16-year period?
Are there discernible trends in the mean age at diagnosis for patients in both the benign and malignant disease groups?
What is the temporal trend of baseline Carbohydrate Antigen 19-9 (CA19-9) levels at initial diagnosis for patients with malignant biliary obstruction?
The expected outcome of this registration is a detailed characterization of the evolving clinical profile of biliary obstruction. It is anticipated that the findings will provide valuable insights for clinicians in diagnosing and managing biliary obstruction, aid healthcare administrators in resource allocation, and inform future public health strategies related to biliary diseases. By documenting these trends, this study seeks to provide a crucial evidence base for adapting clinical practice to the changing epidemiology of this condition