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PDB: 6BFS, Crystal structure of Granulocyte-macrophage colony-stimulating factor (GM-CSF), 311K, 38°C, 100 ns): random seed #1
No full text6BFS, Crystal structure of Granulocyte-macrophage colony-stimulating factor (GM-CSF) 311K, 38°C, 100 ns): random seed #1. PDBs obtained every 50 ns
Replication Data for: Phytoremediation potential and iron fortification of sorghum (Sorghum bicolor L. Moench) in rusty soil from slow sand filtration of groundwater
No full textThe possibilities of phytoremediating rusted sand produced from groundwater purification was assessed. In addition, the possibilities of fortifying plant parts with iron from the soil was examined
Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria
No full textAbstract
The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the induction of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen (CTLA-4) on Treg during malaria and to evaluate their function. We found that P. vivax infection triggered an increase in circulating Treg and their expression of CTLA-4 and PD-1. Functional analysis demonstrated that Treg from malaria patients had impaired suppressive ability and PD-1+Treg displayed lower levels of Foxp3 and Helios, but had higher frequencies of T-box transcription factor+ and interferon-gamma+ cells than PD-1-Treg. Thus malaria infection alters the function of circulating Treg by triggering increased expression of PD-1 on Treg that is associated with decreased regulatory function and increased proinflammatory characteristics
Metformin Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis by Facilitating Nur77-Mediated IDH1 Upregulation
No full textAbstract
This study aims to delve deeper into Metformin (Met)'s cardioprotective mechanisms, particularly its influence on the Nur77-IDH1 axis, expanding upon its established AMPKα-mediated benefits. We employed myocardial ischemia/reperfusion animal models and oxygen-glucose deprivation/reoxygenation in H9C2 cells, utilizing staining techniques, echocardiography, and molecular assays to assess ferroptosis indicators, mitochondrial function, and key proteins like Nur77 and IDH1, elucidating Metformin's cardioprotective pathways. Metformin significantly mitigated myocardial I/R injury in rats, reducing PTGS2 expression, iron and ROS accumulation, and enhancing ATP production and mitochondrial function. It alleviated myocardial tissue damage and fibrosis, and increased survival rates. In OGD/R-induced H9C2 cells, Metformin suppressed ferroptosis, an effect reversed by Nur77 silencing. It increased Nur77 and IDH1 expression and promoted Nur77's nuclear transfer, binding to the IDH1 promoter. Metformin also deactivated the JNK/P38 pathway. However, the IDH1 inhibitor compound 2 negated Metformin's anti-ferroptotic effects, underscoring IDH1's role in this process. Complementary to our previous study, here we suggest that Metformin combats myocardial ischemia/reperfusion injury by inhibiting ferroptosis. The proposed mechanism involves Metformin facilitating Nur77's nuclear transfer, enhancing IDH1 expression, and subsequently inactivating the JNK/P38 pathway. This insight not only underscores Met's potential in myocardial I/R treatment but also highlights the therapeutic value of targeting ferroptosis in heart protection strategies
Replication Data for: The Ideological Asymmetry of White Identity
No full textThis is replication data and code files for the manuscript "The Ideological Asymmetry of White Identity.
Imperfect Okra: An open dataset of imperfect Okra images for training machine vision algorithms for automated recognition and sorting based on produce visual characteristics.
No full textImperfect Okra: An open dataset of imperfect Okra images for training machine vision algorithms for automated recognition and sorting based on produce visual characteristics
Replication Data for: "Cadasters and Economic Growth: A Long-Run Cross Country Panel"
No full textThis is the replication package for "Cadasters and Economic Growth: A Long-Run Cross Country Panel," accepted in 2023 by the Journal of Political Economy
Replication Data for: Solitary and social play behavior varies with age, sex and socio-ecological context in wild, immature orangutans
No full textThis data set contains source code and data files of all analyses reported in the manuscript "Solitary and social play behavior varies with age, sex and socio-ecological context in wild, immature orangutans
Replication Data for: Modelling Policy Action Using Natural Language Processing: Evidence for a Long-Run Increase in Policy Activism in the UK
No full textDFM dataframe and R code for replication. Note that lines 1-219 require access to the original pdf/html documents