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Clinical significance of cold-inducible RNA-binding protein in idiopathic pulmonary fibrosis
Get PDFBACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with a poor prognosis with variable clinical course. Early identification of patients at high risk for disease progression and death would lead to early therapeutic intervention and thereby improvement of outcomes. Cold-inducible RNA-binding protein (CIRBP) is produced in response to cellular stresses, which is implicated in multiple biological processes, including cell survival and proliferation.
RESEARCH QUESTION: Is CIRBP a useful biomarker for predicting the outcomes of patients with IPF?
STUDY DESIGN AND METHODS: This study included 95 and 93 patients with IPF from two independent hospitals (derivation and validation cohorts, respectively). The association s of serum CIRBP level upon IPF diagnosis with disease progression within 1 year after diagnosis (i.e. ?10% relative decline in percent predicted forced vital capacity or death) and all-cause mortality were retrospectively analysed. Discrimination performances for predicting these outcomes were evaluated using the c-index.
RESULTS: Serum and lung tissue CIRBP levels were higher in patients with IPF than in control subjects. In the derivation cohort, the CIRBP high sub-group had significantly higher 1-year disease progression rates and lower cumulative survival rates than the CIRBP low sub-group, and the results were replicated in the validation cohort. In multivariate analyses, high serum CIRBP level was independently associated with higher 1-year disease progression and all-cause mortality rates in both cohorts. Combining the Gender-Age-Physiology and serum CIRBP models improved the c-indices for predicting 1-year disease progression and all-cause mortality compared with that of each model alone. The c-indices of serum CIRBP were particularly high in patients with Gender-Age-Physiology stage I.
INTERPRETATION: This study successfully validated that serum CIRBP level was an independent predictor of 1-year disease progression and all-cause mortality in IPF. CIRBP is a promising biomarker that can help identify high-risk patients with IPF, especially in the early stage.journal articl
ひくまの : 浜松医科大学附属図書館報. No. 71
Get PDF特集 スマート・ライブラリ ; 図書館は知のふるさとに再びなれるのか / 椙村春彦 ; 学生からの寄稿 ; 図書館からのお知らせboo
tDCS-induced modulation of GABA concentration and dopamine release in the human brain: a combination study of magnetic resonance spectroscopy and positron emission tomography
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi
Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi
