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Bactericidal effect of far ultraviolet-C irradiation at 222 nm against bacterial peritonitis
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科thesi
Lipidomics-based tissue heterogeneity in specimens of luminal breast cancer revealed by clustering analysis of mass spectrometry imaging: A preliminary study
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科thesi
Exploring unsolved cases of lissencephaly spectrum: integrating exome and genome sequencing for higher diagnostic yield
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科thesi
A study on postoperative therapy for recurrent ovarian granulosa cell tumor in our hospital
Get PDF卵巣顆粒膜細胞腫（granulosa cell tumor: GCT）に対する術後療法の基準は明確には定まっていない。
再発を反復する症例の臨床経過から、術後療法の要否や化学療法レジメンに関する検討を行った。2006年以降、当科で経験した顆粒膜細胞腫全9症例の病期はⅠa期4例、Ⅰc期4例、Ⅳ期1例で、4例（Ⅰc期3例、Ⅳ期1例）に再発を認めた。全9症例のうち、初回術後療法としてⅣ期1例及びⅠa期の1例に対してBEP（bleomycin+etoposide+cisplatin）療法が、Ⅰa期1例に対してCAP療法（cyclophosphamide+doxorubicin+cisplatin）が施行された。再発を反復している2症例のうち1例では4度目の再発術後にddTC（dose-dense paclitaxel+carboplatin）+ Bev（bevacizumab）、Bev維持療法を行い、長期間の無病生存を得ることが可能であった。顆粒膜細胞腫 Ⅰc期は再発リスクが高く慎重な経過観察の必要性が示唆された。再発腫瘍の術後維持療法にはddTC+Bev、Bev維持療法が有用である可能性がある。Since there are no clear postoperative guidelines for ovarian granulosa cell tumor (GCT) yet, we aimed to investigate its necessity along with a well-defined chemotherapy regimen based on the clinical course of patients with repeated recurrences. Nine cases of GCT have been reported at our department since 2006, of which 4 cases were stage Ia and stage Ic each, and 1 case was stage IV. Among these cases, 4 patients (3 at stage Ic, 1 at stage IV) experienced recurrence. Among the nine enrolled patients, the initial postoperative therapy was BEP (bleomycin+etoposide+cisplatin) in one stage IV patient and one stage Ia patient, whereas one stage Ia patient received CAP (cyclophosphamide+doxorubicin+cisplatin) treatment . Furthermore, in one of the two cases with repeated recurrences, ddTC (dose-dense paclitaxel+carboplatin)+ Bev (bevacizumab) and Bev maintenance therapy after the 4th recurrence surgery resulted in long-term disease-free survival. We observed a high risk of recurrence in stage Ic GCT, necessitating a comprehensive follow-up. Furthermore, it can be concluded that ddTC+Bev along with Bev maintenance therapy may prove to be more effective postoperatively for such recurrent tumors
Prevalence and the influence of trapeziometacarpal osteoarthritis on patients with carpal tunnel syndrome
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科thesi
Iron deposition in gastric black spots: Clinicopathological insights and NanoSuit-correlative light and electron microscopy analysis
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科thesi
Distribution of coronal plane alignment of the knee classification does not change as knee osteoarthritis progresses: a longitudinal study from the Toei study
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科thesi