4569 research outputs found
Sort by
Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi
APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi
Effects of bowel training and defecation posture on chronic constipation in older adults with dementia: a randomized controlled trial
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi
Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction
Get PDF浜松医科大学Hamamatsu University School of Medicine博士（医学）Hair follicles (HFs) function as hubs for stem cells, immune cells, and commensal microbes, which must be tightly regulated during homeostasis and transient inflammation. Here we found that transmembrane endopeptidase ADAM10 expression in upper HFs was crucial for regulating the skin microbiota and protecting HFs and their stem cell niche from inflammatory destruction. Ablation of the ADAM10-Notch signaling axis impaired the innate epithelial barrier and enabled Corynebacterium species to predominate the microbiome. Dysbiosis triggered group 2 innate lymphoid cell-mediated inflammation in an interleukin-7 (IL-7) receptor-, S1P receptor 1-, and CCR6-dependent manner, leading to pyroptotic cell death of HFs and irreversible alopecia. Double-stranded RNA-induced ablation models indicated that the ADAM10-Notch signaling axis bolsters epithelial innate immunity by promoting b-defensin-6 expression downstream of type I interferon responses. Thus, ADAM10-Notch signaling axis-mediated regulation of host-microbial symbiosis crucially protects HFs from inflammatory destruction, which has implications for strategies to sustain tissue integrity during chronic inflammation
Autonomic symptoms
Get PDF通巻第1240号Autonomic symptoms are various symptoms caused by autonomic dysfunction in Parkinson’ s disease, and reflect the systemic Lewy body pathology. Since autonomic dysfunction affects quality of life (QOL) , understanding its symptoms and taking appropriate measures are important in the management of Parkinson’s disease. Symptoms include dizziness, lightheadedness, and syncope associated with orthostatic hypotension, as well as nausea, vomiting, and constipation due to gastrointestinal dysfunction. There are also fluctuations in motor symptoms associated with delayed absorption of levodopa. It is also important to recognize that some symptoms are atypical. Additionally, since treatment of one autonomic symptom may lead to deterioration of other autonomic symptoms, it is important for management of Parkinson’s disease to take individual measures based on the condition and QOL of each patient.journal articl
Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi
Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis
Get PDF浜松医科大学博士（医学）doctoral医学系研究科thesi