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Inter Group Perception and Experience Exploration in the Lives of Northeasterners NE in India
Get PDFOver the years, the importance of historically neglected North East (NE) India has gained momentum. Previous studies in Psychology have focused either on identity of NE people, migration, acculturation or prejudice. Research on perception of NE (Indian) people by non-NE people (Indian) and vice-versa has been scanty. The present study attempts to understand perception of Northeast (NE) students of India by non-NE students (primarily North Indian/NI students staying in Delhi) using a sentence completion task. Participants consisted of female college students and research scholars; (N=30, mean age = 20.8 years). The study also takes into account the rising cases of racism against NE people in India during the COVID-19 pandemic. Results from the empirical study indicate a general and superficial understanding of NE by non-NE participants. Findings are overall positive, showing that educated and aware student community do not explicitly view NE through the lens of stereotype and prejudice. Yet subtle biases were present. On the contrary, a number of news reports point towards the incidences of prejudice and discrimination against NE people during the COVID-19 pandemic. The secondary data analysis clearly indicates the level of dehumanisation and discrimination that NE people are experiencing. Thus the study calls for more attention of researchers to dive deeper into these opposite trends and bring out the subtle forms of misperceptions to bridge the gulf between NE people and non-NE people. Results indicate that perhaps positive changes are happening only at explicit level, and at implicit level people still harbour negative perceptions and attitudes, which manifests during times of crisis. The findings have been explained with the help of Terror Management Theory
Nuclear Security Architecture & Radiological Disaster Response in India Progress and Challenges
Get PDFThe nuclear security architecture in India is three-fold: the infrastructure security including physical security of the nuclear plant; port and border security including training and capacity building to prevent any illicit trafficking of nuclear material into the country and; the inter-institutional coordination at the Centre and State level during radiological emergencies. However, there exist structural weaknesses that need to be accounted for in all these three areas. It is imperative to develop capacities not only for safe handling, transport and disposal of nuclear material but also instituting stringent cyber-security laws, border security measures and functional Centre-State coordination in crisis situation for the safety and security of the general population. The following paper seeks to address these challenges and provide recommendations for strengthening the nuclear security and disaster response framework in India. The paper draws recommendations from the 2019 IPCS workshop on Smuggling and Radiation Detection, on the illicit trafficking of radioactive materials supported by the Office of Nuclear Smuggling Detection and Deterrence (NSDD) of the United States Department of Energy (DOE)
Molecular Docking Studies of Coronavirus Proteins with Medicinal Plant Based Phytochemicals
Get PDFIn this study, we presented an in silico molecular docking between the SARS-CoV-2 four proteins [(a) SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain (6M3M), (b) Nsp9 RNA binding protein of SARS CoV-2 (6W4B), (c) The crystal structure of COVID-19 main protease in apo form (6M03), and (d) Structure of the 2019-nCoV HR2 Domain (6LVN)] available in the PDB (Protein Data Bank), and the medicinal plant-based phytochemicals (retrieved from PubChem database) as ligand molecules i.e. Piperine (Black Pepper), Eugenol (Clove), Alliin (Garlic), Gingerol (Ginger) and Curcumin (Turmeric). All these ligand molecules showed good docking with their respective receptor molecules and their scores range from -8.195 to -5.263. DockThor Portal (a receptor ligand-docking server) which was recently developed and published this year were used in the current study. The obtained results might help in the wet lab conditions to develop better antiviral compounds against SARS-CoV-2
Evaluation of Phyto Chemical Biochemical and In Vitro Antioxidant Potential of Angelica Glauca Grown at High Altitude Areas of Western Himalayas
Get PDFAngelica glauca Edgew is an important medicinal and aromatic herb (family Apiaceae). The roots of A. glauca commonly used as spices by local peoples. In the present study, the phytochemical constituents, biochemical parameters and, in-vitro antioxidant activity of A. glauca roots collected from the Himalayan region have been studied. For preliminary phytochemical analysis, the hydroalcoholic and aqueous root extract of Angelica glauca were screened for the presence of carbohydrates, protein, alkaloids, glycosides, sterols, triterpenes, saponin, tannins, phenols, flavonoids, and coumarin. The biochemical parameter and in-vitro antioxidant potential of Angelica glauca were analysed by using standard methods. Phytochemical analysis of extract showed major classes of phytochemicals constituents such as carbohydrates, protein, alkaloids, glycosides, sterols, triterpenes, saponin, tannins, phenols, flavonoids, and coumarin. The results from the current study demonstrated that A.glauca roots contained carbohydrate (21±0.72 %), crude protein (12.7±0.31 %), total ash (3.86±0.034 %), dietary fiber (18.9±0.14 %), total fat (4.5±0.38 %) and ascorbic acid (68.5±0.19mg/100g). The hydroalcoholic extract showed the highest quantity of total phenol, total flavonoids, and total tannin content compared to aqueous extract. The hydroalcoholic extract exhibited high DPPH radical scavenging activity (IC50=68.1±0.34 µg/ml). The result showed that A.glauca roots have high nutritional and antioxidant potential. Hence the plant can be used as a nutraceutical and natural antioxidant
Role of H2S Supplementation on Burn Wound Healing and Molecular Chaperones
Get PDFTreatment of non-healing burn injuries is a major challenge for the current scientific research. Hydrogen sulfide (H2S) is an endogenous gasotransmitter, which regulates redox homeostasis and cytoprotection during pathophysiological conditions. Similarly, heat shock proteins (HSPs) are molecular chaperones, which also confer cytoprotection during the wound repair process. Notably, the role of H2S as a regulator of HSPs during burn wound healing is still elusive. The present study investigated the effects of H2S supplementation on molecular chaperones during full-thickness, third-degree burn wound healing in the experimental rats. The animals were treated with sodium hydrosulphide (NaHS) as H2S donor (5 mg/kg body weight, intraperitoneal) daily for 10 days prior to burn-induction and continued till the fifth-day post-wounding. Histopathological analysis (Masson’s trichrome) revealed enhanced wound healing evident by increased collagen fiber deposition, cellular proliferation and re-epithelialisation in NaHS administered group as compared to the burn control. Furthermore, immunoblot analyses demonstrated significantly increased protein expression of molecular chaperons viz. HSP90, HSP70, HSP27, and GRP78 in H2S treated group as compared to control. Therefore, the present study signifies that H2S supplementation upregulates the protein expression levels of molecular chaperones, which could facilitate the cytoprotection during the tissue repair process and accelerates the burn wound healing
Psychosocial Response to National Security
Get PDFNational security is perhaps one of the key areas of research which receives continuous attention from the scholars of strategic studies, military science, and of course some of the disciplines of social science such as political science and international relation. One way of pursuing interest in national security is to delve the threat perception which emanates from across the border and is likely to influence socio-political sphere of the nation. On the other hand, the diversity in the socio-cultural landscape of the nation characterized by ethnicity and linguistic based sub-national identities is equally important so far as enriching one’s knowledge base in the domain of internal security is concerned. Within the realm of psychology, military psychology is possibly one sub-discipline which tries to address this gap. However, psychology is yet to receive a space in the intellectual terrain of studies on national security
Radiation Induced Gene Expression Signatures for Triage Biodosimetry
Get PDFMedical management of radiation emergencies will require quick and reliable biodosimetric tools for assessment of absorbed dose. Dicentric chromosomal assay (Gold standard) has a limitation of being time intensive, requires specialised human skill and cannot be used for triage and mass screening. Dose assessments of suspected individuals are critical for the medical management of radiation emergencies. For effectively utilizing the available resources, there is an urgent need for developing triage biodosimetry tools for determining the exposure status of suspected individuals. High-throughput methods, utilising the novel “omics” science approaches are emerging as new technologies and gene expression-based biodosimetry is considered a promising technique for radiation dose assessment. Gene expression signatures of radiation have demonstrated the potential for triage biodosimetry. It is a minimally invasive, rapid and reliable approach that has the ability to be a robust field-deployable point-of-care high throughput technique. In addition gene expression based biodosimetry can be useful for long-term epidemiological assessment, clinical radiation oncology and radiodiagnosis
Tyrosine Supplementation A Nutraceutical Approach to Counter Heat Stress Induced Cognitive Decline
Get PDFSupplementation of tyrosine, non-essential amino acid, and precursor of catecholamine was found to ameliorate the heat-induced alterations in latencies of event-related potential P300 and contingent negative variation. Here we present the effect of tyrosine supplementation on heat stress (exposure to ambient temperature 45 oC and relative humidity 30 %) induced alterations in behavior (attention, mood) and levels of plasma monoamines. Ten healthy male participants received a placebo food bar or tyrosine-containing food bar (6.5 g in 50 g) 90 min before heat stress exposure of 90 min. Plasma and urine samples were assayed for catecholamine levels, their precursor, and metabolites using high-performance liquid chromatography. A computer-based automated test battery was used to assess attention and mood by profile of mood states questionnaire. A significantly higher plasma tyrosine (p<0.001) leading to an increased norepinephrine (p<0.05) levels in the tyrosine supplemented group was observed. Selective (p<0.001) and sustained attention (p<0.02) in the tyrosine group were significantly better compared to the placebo group. Reaction time and anger scores decreased (p<0.001) with tyrosine supplementation. It may be concluded that tyrosine supplementation improves heat stress-induced decrement in attention by maintaining the synthesis and turnover of norepinephrine
Soil Physico Chemical Properties and Macronutrients Evaluation during Sowing and after Harvesting of Crop at High Altitude Leh Ladakh India
Get PDFThe present study was aimed to investigate the effect of physico-chemical parameters and soil macro-nutrients to know the nutrient uptake status during sowing time (ST) and after the harvesting (AH) of crops of Leh-Ladakh. In this context, total 55 no. of soil samples were collected from the eleven villages. Thereafter, soil texture, pH, electrical conductivity (EC), total dissolved solids (TDS), organic carbon (OC), nitrogen (N), phosphorus (P), and potassium (K) were analyzed as per the standard methods. The results exhibited variation in different studied parameters at ST and AH, are OC (ST- 1.70 ± 0.11; AH-2.31±0.08), N (ST- 171.54±11.40; AH- 212.03±13.18), P (ST- 75.62±8.16; AH- 96.32±11.56), pH (ST- 8.12±0.05; AH- 8.16±0.06), EC (ST- 0.48±0.04; AH- 0.58±17), TDS (ST-309±22.41; AH-189±16.42) and soil texture gradient (Sand: ST-75.16±1.27 & AH-71.75±1.26, Silt: ST- 18.55±1.09 & AH- 20.66±1.02 and clay: ST- 6.33±0.53 & AH- 7.76±0.63). The comparison of physico-chemical parameters, macronutrients, soil texture, and organic carbon at sowing time (ST) and after harvesting (AH) revealed significant difference in some macronutrients, EC, and organic carbon, whereas no changes were observed in soil texture, pH and phosphorus. Hence, this study highlights the need of physico-chemical parameters management during crops sowing for enhancing macronutrients availability to crops in trans-Himalayan high altitude region