Walter Sisulu University
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Change in renal function post-nephrectomy for renal cell carcinoma in patients with and without hypertension and/or diabetes
Get PDFBACKGROUND: The standard of care for surgically resectable disease renal cell carcinoma (RCC) is a nephrectomy. Post nephrectomy, these patients are at risk for the development of new onset chronic kidney disease or the progression of pre-existing chronic kidney disease. We aimed to report the changes in renal function in patients who had a nephrectomy for RCC METHODS: This retrospective, descriptive, cross-sectional study identified 137 patients who had a nephrectomy for RCC from 1 January 2009 to 31 December 2017. The pre-nephrectomy and post-nephrectomy estimated glomerular filtration rate (eGFR) and the histological subtype of RCC on histopathological analysis of the resected specimen were recorded from the National Health Laboratory Services online results platform. All analyses were conducted using SPSS (Version 25) and the significance level was set at p < 0.05 RESULTS: After a mean follow-up period of 26.5 ± 22 months (median = 19 months), the patients' eGFR dropped by a mean of 4.82 ± 8.67 ml/min/1.73 m2 (95% CI 3.23-6.41) post-nephrectomy. The mean eGFR fall in patients' who had hypertension and/or diabetes (n = 63) was significantly larger compared to patients who had neither of these comorbidities (n = 54; p < .001; mean = 7.30 ± 8.40 ml/min/1.73 m2 (95% CI 5.19-9.42) and 1.93 ± 8.14 ml/min/1.73 m2 (95% CI 0.30-4.15) respectively CONCLUSIONS: The decline in renal function in patients with hypertension and/or diabetes mellitus is more pronounced than in patients with neither of these comorbidities. In these high-risk patients, measures must be taken to prevent the development and limit the progression of chronic kidney diseas
Investigation of the effects of selected bio-based carburising agents on mechanical and microstructural characteristics of gray cast iron
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Some Remarks on the Solution of Linearisable Second-Order Ordinary Differential Equations via Point Transformations
Get PDFMorphology, histology and histochemistry of the digestive tract of the Banded tilapia, Tilapia sparrmanii (Perciformes: Cichlidae)
Get PDFAcceptability of self- collection for human papillomavirus detection in the Eastern Cape, South Africa
Get PDFTraining a Fit-For-Purpose Rural Health Workforce for Low- and Middle-Income Countries (LMICs): How Do Drivers and Enablers of Rural Practice Intention Differ Between Learners From LMICs and High Income Countries?
Get PDFDevising communication strategies for improving public awareness on responsible antibiotic use: A case study of WHO campaign
Get PDFExploring Literacy Challenge Encountered by Senior Phase English First additional language learner a perceived by Teacher in Lusikisiki ub district
Get PDFThesis (M.Ed) -- Faculty of Education Sciences, 202
Exploring the Teaching and Learning of Euclidean Geometry in Senior Secondary Schools: The Case of O R Tambo Coastal Schools
Get PDFThis study was aimed at exploring the teaching and learning of Euclidean Geometry in five selected senior secondary schools in the O R Tambo Coastal District of the Eastern Cape, South Africa. The literature review was based on existing knowledge in the teaching and learning of Euclidean geometry. The study was built on analyzing the effective teaching strategies based on the teacher’s Pedagogical Content Knowledge (PCK) in Euclidean Geometry (EG). Shulman and Ma’s perspective on teachers’ competencies and knowledge of Mathematics was used as the theoretical framework of the study. A mixed-methods sequential explanatory design was adopted for the study. A purposive convenience sampling technique was used to select research sites and participants. The main instruments used were questionnaires, semi-structured interviews, classroom observation schedules, and document analysis. Quantitative data was analyzed descriptively utilizing tables and graphs. Qualitative data were analyzed using thematic data analysis. The various findings were interpreted through the literature and the theoretical framework. It was found that learners have a poor foundation in geometry and the methods teachers employed to teach Euclidean Geometry were inappropriate. Recommendations and suggestions were made. It is hoped that these recommendations would be noted by the appropriate stakeholders to ensure that improvement in the teaching and learning of Euclidean Geometry is achieved in our secondary schools to help matriculates’ obtain good marks in the final certification examination. Keywords: Euclidean Geometry, geometry teaching and learning; learners’ attitude; Teachers Pedagogical Content KnowledgeThesis (M.Ed) -- Faculty of Education Sciences, 202