Walter Sisulu University
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Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis
Get PDFFactors affecting specialist psychiatry training in South Africa: Bullying during specialist psychiatric training?
Get PDFBehavioural activities and chemical composition of fresh leaf essential oil of Plectranthus aegyptiacus from Southwest Nigeria in mice
Get PDFThis study determined the chemical composition of essential oil obtained from fresh leaf of Plectranthus aegyptiacus, and evaluated it for novelty-induced behavioural (NIB) and determine its mechanism(s) of action in mice. The oil was hydro-distillated, and analyzed using gas chromatography-mass spectrometry. The effects of the oil (50, 100 and 150 mg/kg; i.p., n=6) on novelty-induced behavioural was assessed using open field test and head dipping on hole board. Probable mechanism(s) were evaluated using antagonists: flumazenil, naloxone and cyproheptadine at 2 mg/kg each, atropine and yohimbine at 5 mg/kg and 1 mg/kg respectively. The LD50 values obtained were 2154 and 490 mg/kg for oral and intraperitoneal routes respectively. The oil (50, 100 and150 mg/kg) significantly (p less 0.05, 0.01 and 0.01) inhibited all NIB and head dips. Flumazenil significantly (p less than 0.05) reversed the effect of the oil on NIB; atropine, naloxone and cyproheptadine significantly (p less than 0.01, 0.01 and 0.001) potentiated inhibitory effect on NIB respectively, while yohimbine showed no significantly effect. The analyzed oil showed 61 compounds, and the major compounds were carvacrol, germacrene-D, p-cymene and [1,1'-Bicyclopentyl]-2,2'-diol. The study concluded that the oil possessed central nervous system depressant activity, which could be mediated mainly through augmentation of GABAergic neurotransmission, while cholinergic-(muscarinic), adrenergic and serotonergic pathways may be involved
Developing Rural Economies through Small to Medium Tourism Enterprise: the case of Matatiele and Cedarville in the Eastern Cape, South Africa
Get PDFGlobally, nations depend on small businesses as engines for economic growth. Small to Medium Tourism Enterprises (SMTEs), as part of the small business sector, are increasingly becoming important in terms of job creation, wealth creation and driving economic growth in smaller rural geographic areas. Utilising a mixed research approach, the paper identifies characteristics of SMTEs in Matatiele and Cedarville with the intention of identifying specific ways in which they can be supported to attain their real potential in enabling economic development in rural environment. Purposive sampling method was used to select respondents and self-administered questionnaires utilised to gather relevant data from managers/owners. The results indicate that the rural tourism is dominated by female-owned enterprises primarily offering accommodation services. Most of the enterprises have been in operation for a period of more than five years which points to potential growth as they are able to survive. The results further show that the businesses that participated in the survey intent employing more full-time employees. Furthermore, the results underscore that there is lack of local government support to promote entrepreneurship in the SMTEs sector particularly those that are located in the rural environment. The findings elucidate the ability of SMTEs to greatly reduce the high unemployment in rural economies if appropriate systems are put in place to support these enterprises. These findings have implications for the national, provincial and local government spheres in South Africa in their quest to create job opportunities in rural areas through entrepreneurship and SMTEs in order to provide impetus to the Eastern Cape Province and South African Economy. This pape
Outcomes of Drug Resistant Tuberculosis in Two Rural District Hospitals, Eastern Cape Province, South Africa
Get PDFTuberculosis (TB) is still rampant in South Africa, and drug resistant tuberculosis (DR-TB) forms a significant part of this burden on both the health care system and economy. A number of interventions have recently been introduced to help curb the growing epidemic of DR-TB, including increasing access to novel and repurposed drugs, decentralisation of care, and a new shorter (9-11 month) treatment regimen recently endorsed by the World Health Organization (WHO). Significantly, this new regimen has now also become injectable-free (also known as an all-oral regimen). However, at the time of implementation in 2017, the shorter regimen was yet to be proven effective in a programmatic setting in South Africa. This is a retrospective cohort study to describe the outcomes in patients on short and long DR-TB treatment regimens, over five years, at two treatment sites in a rural setting in the Eastern Cape province of South Africa. It is the hope that elucidation of factors involved in affecting outcomes in DR-TB may direct future interventions in these two facilities, and the wider DR-TB program in South AfricaThesis (Masters) -- Faculty of Health Sciences, 202
Cereal stem borer (Lepidoptera) assemblage structure in a sub-tropical agro-ecosystem, Eastern Cape Province, South Africa
Get PDFInsect pests, especially lepidopterous stem borers, cause significant losses to cereal production at local and global scales. The borer species associated with cultivated grain cereals and alternative wild host plants were identified at three elevation gradients in the former Transkei area of the Eastern Cape Province, South Africa. Stem borer sampling was undertaken during maize crop and non-crop seasons in Port St Johns (PSJ), Mthatha and Elliot, sites that differ in elevation above sea level, annual precipitation and temperature. Morphologically identical borers retrieved from each sampling unit were recorded, processed and reared to adult stage for identification at an ambient temperature range of 25–28°C and a relative humidity range of 65–80%. Specimens were sorted first into morphospecies (MS1–MS6) based on external morphological characteristics. Six stem borer species (Busseola fusca, Sesamia calamistis, Eldana saccharina, Chilo orichalcocili, Chilo sacchariphagus and Chilo partellus) were collected during the survey. E. saccharina and C. orichalcocili were absent in PSJ; in Elliot, E. saccahrina occurred in very low numbers whereas C. partellus was absent. Busseola fusca was more abundant at high altitude (i.e. Elliot). Borer community structure in the study showed similarity between Mthatha and Elliot. Species richness and abundance across study sites were not statistically significant (P > 0.05). The study provides information on borer species occurrence in the study area, and techniques to identify larval stages for effective control by local farmers and extension workers. When designing strategies for borer control, elevation may not be a major concern at this spatial scale
Atypical HIV-vacuolar myelopathy: a case report :
Get PDFBackground: Here, we report an atypical HIV-vacuolar myelopathy and search the available medical literature about atypical presentations of human immunodefciency virus associate vacuolar myelopathy (HIV-VM) and immunoglobu‑ lin therapy response. Case: A 26-year-old lady who was 4 weeks postpartum presented to us with acute faccid quadriparesis, with no sen‑ sory level. Extensive workup ruled out other causes of myelopathy. She developed a stage 3 acute kidney injury, and MRI showed difuse cord atrophy involving the lower cervical and thoracic cord. The patient received IV-immunoglob‑ ulin, ARVs, and supportive therapy with inadequate response. Unfortunately, she developed nosocomial pneumonia and died. Discussion: In HIV-VM, there is spinal cord atrophy, which mainly involves the thoracic cord. In our case, this patho‑ logical process also afected the spinal cord’s cervical region, leading to faccid tetraplegia, with high CD4 level, with‑ out response to the treatment, including intravenous immunoglobulin. Keynotes: Vacuolar myelopathy, HIV, Immunoglobulin therapy, faccid tetraplegia, hypokalaemia. Renal failure. Keywords: Human immunodefciency virus, Associated lesions of the nervous system, Human immunodefciency virus-associated myelopathy, Intravenous immunoglobulin administration, Case report, HIV-vacuolar myelopath
Determinants of Job Satisfaction Among Academics at A Selected Institution of Higher Learning in The Eastern Cape Province of South Africa
Get PDFMany studies have considered job satisfaction and its antecedents in the profit making sector. These studies have provided a number of factors that influence job satisfaction including autonomy, compensation, growth opportunities, leadership styles, task variety and so on. There are numerous factors that have been discovered to positively influence job satisfaction. Interest in job satisfaction arises from the fact that productivity and other favourable organisational outcomes such as service delivery and quality of outputs have been found to associate with job satisfaction. This study followed a quantitative approach based on a Likert questionnaire to collect data on the antecedents of employee job satisfaction within a Higher Education Institution (HEI) in South Africa. It was established that antecedents of job satisfaction in the HEI resembled closely those established in the literature. It is recommended that HEI should consider factors such as remuneration, task variety, work autonomy, good workplace relations and leadership styles to foster employee motivation. Keywords: Job Satisfaction, Higher Education Institutions, Human Capital, Productivit
Demographical variables and entrepreneurial disposition: a narrative overview of literature
Get PDFSignificant scholarship on the criticality of entrepreneurship to economic development exists. Policy makers have also accepted existing entrepreneurship and economic development theories in efforts to drive economic development reduce poverty, unemployment and increase wealth levels of the populations. In view of this, researches on the qualities and related predictors or antecedents that are related to the inclination of individuals to engage in entrepreneurial activities have been considered. The present study sought to pull together research studies on the demographical variables that affect entrepreneurial disposition. A narrative overview of literature anchored the study. The study found that most sections of the literature on predictors of entrepreneurial disposition have focused on personal attitudes, personality traits and qualities that increase the likelihood of an individual to engage in entrepreneurship. Gender has been the most prominent demographical variable that has received scholarship and it has been established that males seem to be more predisposed to engage in entrepreneurship than females, even though female entrepreneurship is on the rise. Studies on age have suggested that entrepreneurial predisposition seems to ascend among the younger age groups to a peak around middle age before it starts to decline. It appears that consideration of other demographical variables such as marital status, race and place of origin have not been adequately explored
Malnutrition in children under the age of 5 years in a primary health care setting
Get PDFIn this study, we outlined the types of malnutrition amongst children, the causes of malnutrition intervention at the primary health care level and some recommendations to alleviate childhood malnutrition in South Africa. Keywords: obesity; severe acute malnutrition; individual factors; community level factors; dietary intervention