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Notification de la décision de préemption au notaire du vendeur. Quid du point de départ du délai de recours ?
No full textInternational audienceConseil d'État, 7 mars 2025, no 495227, Consorts D., Lebon T
Droit de préemption urbain. L'intérêt à agir du propriétaire en indivision
No full textInternational audienceConseil d'État, 7 mars 2025, no 490933, M. B., Lebon T
Challenging Spontaneous Quantum Collapse with XENONnT
No full textInternational audienceWe report on the search for X-ray radiation as predicted from dynamical quantum collapse with low-energy electronic recoil data in the energy range of 1-140 keV from the first science run of the XENONnT dark matter detector. Spontaneous radiation is an unavoidable effect of dynamical collapse models, which were introduced as a possible solution to the long-standing measurement problem in quantum mechanics. The analysis utilizes a model that for the first time accounts for cancellation effects in the emitted spectrum, which arise in the X-ray range due to the opposing electron-proton charges in xenon atoms. New world-leading limits on the free parameters of the Markovian continuous spontaneous localization and Diósi-Penrose models are set, improving previous best constraints by two orders of magnitude and a factor of five, respectively. The original values proposed for the strength and the correlation length of the continuous spontaneous localization model are excluded experimentally for the first time
Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders
No full textInternational audienceMicro RNAs (miRNAs) play a crucial role as regulators of various biological processes and have been implicated in the pathogenesis of mental disorders such as schizophrenia and bipolar disorders. In this study, we investigate the expression patterns of miRNAs in the PsyCourse Study (n = 1786), contrasting three broad diagnostic groups: Psychotic (Schizophrenia-spectrum disorders), Affective (Bipolar Disorder I, II and recurrent Depression), and neurotypic healthy individuals. Through comprehensive analyses, including differential miRNA expression, miRNA transcriptome-wide association study (TWAS), and predictive modelling, we identified multiple miRNAs unique to Psychotic and Affective groups as well as shared by both. Furthermore, we performed integrative analysis to identify the target genes of the dysregulated miRNAs and elucidate their potential roles in psychosis. Our findings reveal significant alterations of multiple miRNAs such as miR-584-3p and miR-99b-5p across the studied diagnostic groups, highlighting their role as molecular correlates. Additionally, the miRNA TWAS analysis discovered previously known and novel genetically dysregulated miRNAs confirming the relevance in the etiology of the diagnostic groups. Importantly, novel factors and putative molecular mechanisms underlying these groups were uncovered through the integration of miRNA-target gene interactions. This comprehensive investigation provides valuable insights into the molecular underpinnings of severe mental disorders, shedding light on the complex regulatory networks involving miRNAs
Triarylphosphonium BODIPY‐Based [2]Rotaxanes Nanoparticles for Light‐Driven Antibacterial Applications
No full textInternational audienceAntimicrobial photodynamic therapy (aPDT) is a promising strategy to overcome issues related to antibiotic resistance. Here the rationale for designing new photosensitizers is described based on the functionalization of bodipy dyes with triarylphosphonium rotaxanes, and an in-depth characterization of their photophysical properties, applying different spectroscopic techniques, including ultrafast transient absorption spectroscopy is provided. While the addition of halogen atoms to some of the structures provides them the ability to efficiently produce singlet oxygen in organic solvents, such property is suppressed in water, where all the investigated compounds aggregate into spherical nanoparticles. The latter, independently of the presence of bromine, demonstrate high photothermal conversion efficiency and have been tested as photosensitizers in antibacterial photothermal therapy, highlighting the potential of self-assembled organic nanostructures based on bodipy dyes for developing new and versatile nanomaterials for photomedicine application
Characterization and Treatment Outcomes of Malignant Histiocytoses in a Retrospective Series of 141 Cases in France
No full textInternational audienceMalignant histiocytoses (MH) are rare and poorly understood cancers, with no established therapeutic guidelines. We conducted a national retrospective study of MH diagnosed in France between 2000 and 2023. All cases underwent centralized histological review, and several malignant tumors with a stroma highly enriched in histiocytes were excluded. In total, 141 patients were included, with a median age of 62 years (range, 1-87). The cases comprised either primary MH (64%) or MH associated with other hematologic malignancies (36%). Phenotypes corresponded to histiocytic (43%), interdigitating dendritic cell (37%) or Langerhans cell (12%) sarcomas, or high-grade indeterminate dendritic cell tumors (10%), as per the World Health Organization classification. Tumor cells were almost universally positive for CSF1R and PU.1, and 85% showed phosphorylated extracellular signal-regulated kinase positivity. Next-generation sequencing was performed in 75 cases. Mutations in the MAPK pathway were more frequent in secondary compared with primary MH (90% vs 55%; P = .0012). PTPN11 mutations were exclusively observed in primary MH (P = .0035). Mutations in genes related to DNA methylation mechanisms (TET2, ASXL1, DNMT3A) and TP53 were present in 20% and 14% of cases, respectively. Although therapeutic regimens varied considerably, our results demonstrate that surgical resection in localized cases, and the use of BRAF or MEK inhibitors achieved the highest complete response rates, at 63% and 21%, respectively. The prognosis remains poor, with a 5-year overall survival rate of 31%, which is comparable to that of T/natural killer cell lymphomas. Prospective follow-up and a standardized treatment approach in specialized reference centers are crucial to improving patient survival. This trial was registered at www.clinicaltrials.gov as #NCT04437381
Conclusive evidence of magnetic rotational band in Fe: Extending the shears mechanism to the fp shell orbital
No full textInternational audienceA Magnetic Rotational (MR) band in 57Fe nucleus has been newly identified and established from the decreasing behaviour of the experimental electric dipole transition probabilities, B(M1), determined from the measured lifetimes of the states. This becomes the first nucleus in the lighter mass (A<60) region in which, the B(M1) values of an MR band are measured. A single-particle configuration of πf7/2−2⊗ν(p3/2f5/2p1/2)3 has been assigned to this MR band. This configuration, which involves only the negative parity proton and neutron orbitals below and above the Z,N = 28 shell closures, respectively, is a unique one which was not identified before for an MR band. The range of observed angular momenta for this band is congruent with this configuration and the experimental data are found to be in agreement with the SPAC (Shears mechanism with Principal Axis Cranking) and semi-classical calculations. Shell model calculations with GXPF1A interaction reproduce the observed levels in 57Fe including the band head of the MR band. This validates the assigned configurations of this band
L’image de l’âme chez Balzac à travers le prisme du merveilleux médical.
No full textInternational audienceIn this article I explore the marvellous which emerges, in a number of Balzac’s texts from the 1830s, from the intersection between the medical ideas of his time and the aesthetic gaze. Despite the publication of fundamental works, in the first decades of the nineteenth century, on general, clinical, and pathological anatomy, a number of different visions regarding the life of the body—visions that still included ‘the marvellous and superstition’ according to Claude Bernard in 1865—continued to be debated since the previous century. Balzac’s resistance to science’s will to banish any notion of the marvellous from physiology, can be seen in his different ways of depicting the presence of a soul in a body. Against the backdrop of the Parisian anatomo-clinical school, of whose importance Balzac was keenly aware—a school that sharpened its gaze in the amphitheatres and dissecting rooms of the school of Fine Arts—, I examine the conception and the ‘visual’ representation of the soul in Balzac’s works, in order to show how this conception intersects medicine, art, and sculpture, in order to join the marvellous.Dans cet article, nous explorons l’apparition du merveilleux qui surgit, dans certains textes de Balzac des années 1830, au croisement des idées médicales de l’époque et du regard esthétique. Malgré la publication de travaux fondamentaux, dans les premières décennies du XIXe siècle, sur l’anatomie générale, clinique et pathologique, plusieurs conceptions de la vie du corps—conceptions qui acceptaient encore « le merveilleux et la superstition » dit Claude Bernard en 1865—continuaient de se débattre depuis le siècle précédent. La résistance de Balzac à la volonté scientifique de bannir la notion du merveilleux de la physiologie, est illustrée dans ces différentes manières de dépeindre une présence de l’âme dans un corps. Avec en toile de fond l’école anatomo-clinique parisienne que Balzac comprenait si bien—école qui aiguisait son regard dans les amphithéâtres et les salles de dissection des Beaux-Arts—, nous examinons la conception et la représentation « visuelle » de l’âme chez Balzac, afin de montrer comment cette conception traverse la pensée médicale, l’art, et la sculpture, pour rejoindre le merveilleux
Unveiling the link between phytoplankton molecular physiology and biogeochemical cycling via genome-scale modeling
No full textInternational audienceEarth system models (ESMs) highly simplify their representation of biological processes, leading to major uncertainty in the impacts of climate change. Despite a growing understanding of molecular networks from genomic data, describing how changing phytoplankton physiology affects biogeochemical processes remains elusive. Here, we embed genome-scale models within a state-of-the-art ESM to deliver an integrated understanding of how gradients of nutrients modulate the molecular physiology of various plankton. In particular, when applied to Prochlorococcus , we find that glycogen and lipid management can be interpreted in terms of acclimation to different environments. Generalized to other phytoplankton such as the diatom Thalassiosira , we estimate the production of 39 metabolites that constitute hot spots of dissolved organic carbon described by their amount of carbon produced and their diversity of associated metabolites in ESMs. This modeling approach shows how genome scale–enabled ESMs have the potential to advance our understanding of microbial ecosystem functioning in ocean biogeochemical processes
Real-Time Jump Activity Recognition and Jump Height Estimation using IMU
No full textAccurate recognition of jump activities and estimation of jump height are essential tasks in biomechanical analysis and sports performance research. This study introduces a realtime approach based on a low-cost Inertial Measurement Unit (IMU), to estimate jump height. Two state-of-the-art methods -Time of Flight (ToF) and Double Integration (DI) -are implemented and compared to evaluate their accuracy and applicability in real-world scenarios. Complementary signal processing techniques are also applied to reduce noise and improve reliability. The system is developed in collaboration with Les Neptunes de Nantes, a professional women's volleyball club in France, and aims at serving as a practical tool for field-based analysis. The results support the feasibility of using a wearable IMU to provide accurate real-time jumping activity recognition and jump height estimation