97557 research outputs found
Sort by
A Comparative Study of a Non-Small Cell Lung Cancer Associated EGFR Missense Variant of Uncertain Significance
Get PDFNon-small cell lung cancer (NSCLC) is a form of lung cancer that can be driven by heightened activity of epidermal growth factor receptor encoded by the EGFR gene. Genetic variants in EGFR have been identified that lead to abnormal cell growth and tumorigenesis. The objectives of this study was to 1) determine if an EGFR variant of uncertain significance (VUS) associated with NSCLC is potentially damaging based on evaluation of the ortholog let-23 in the model organism, C. elegans, and 2) identify conserved missense VUS loci associated with NSCLC. Through ClinVar, the EGFR VUS c.845G\u3eC(p.Gly282Ala) was identified in a conserved loci through multiple sequence alignments. Additional analyses were carried out to examine the EGFR VUS’s amino acid chemical class properties and PolyPhen-2 score. Between the wildtype and mutant amino acid chemical class properties, the classification remained consistent with the initial glycine being non-polar, hydrophobic and the mutant change to alanine with similar properties. PolyPhen-2 predicts the EGFR VUS to be probably damaging to the encoded protein (HumDiv=0.999). In addition, protein models were constructed to examine potential structural changes observed between the encoded native and mutant VUS proteins in human and C. elegans. Further investigation will examine the VUS in vivo through the C. elegans let-23 ortholog and model system. Two sets of DNA primers were designed and optimized through polymerase chain reaction (PCR), amplifying the EGFR VUS loci in nematode let-23. To target let-23, a CRISPR RNA guide was designed. These molecular reagents will be utilized for future CRISPR-Cas9 experimentation and microinjection to generate the let-23 VUS C. elegans model. This study aims to provide a comprehensive evaluation of a NSCLC associated EGFR VUS, elucidating its potential clinical significance on its implication for NSCLC and human health
Noises Off (2024) | Image 008
No full textPerformed 19-22 April 2024; Michael Frayn\u27s Noises Off is a British farce of theatrical accidents, from mishaps onstage and backstage to script and casting flaws, and even direction and management. The play was directed by Carolyn Conover. Grayson Singleton was stage manager and Semaje Newton and Skylee Vaughn were assistant stage managers. Access to this digital image was provided by JSU Photographic Services.https://digitalcommons.jsu.edu/productions_images/12294/thumbnail.jp
Noises Off (2024) | Image 017
No full textPerformed 19-22 April 2024; Michael Frayn\u27s Noises Off is a British farce of theatrical accidents, from mishaps onstage and backstage to script and casting flaws, and even direction and management. The play was directed by Carolyn Conover. Grayson Singleton was stage manager and Semaje Newton and Skylee Vaughn were assistant stage managers. Access to this digital image was provided by JSU Photographic Services.https://digitalcommons.jsu.edu/productions_images/12303/thumbnail.jp
Machinal (2024) | Program
Get PDFPerformed 8-11 November 2024; Sophie Treadwell\u27s Machinal is an Expressionist play based on the murder trials of Ruth Snyder and Henry Judd Gray. The play was directed by Carolyn Conover, stage management by El Hataway and Lydia Roan (assistant), technical direction by John Davis, costume design and makeup design by Skylee Vaughn, choreography by Alison Woodward and Carolyn Conover (intimacy choreographer), intimacy/dance captains were Semaje Newton and Stanton Yarboro, lighting design by Alli Angel, scenic design by Addie Zaner, sound design by Randy Blades. This item is contained within the Theatre & Film Production Archive.https://digitalcommons.jsu.edu/productions_all/1208/thumbnail.jp
Quoted Message Poster 1
No full textEight of these posters (dimensions 24x35 inches) feature quotes from renowned designers that support the research and objectives of the proposed methodology.https://digitalcommons.jsu.edu/etds_mfa_images/1111/thumbnail.jp
Exhibition Digital Displays 1
No full textImage of exhibition displays with poster.https://digitalcommons.jsu.edu/etds_mfa_images/1109/thumbnail.jp
Communication is Key
No full textWhat if you were non-verbal due to a disability such as autism, down syndrome, traumatic brain injury or cerebral palsy? How would you communicate your feelings, your answers to questions, or your wants and needs? Using the Sounding Board, Go Talk, Sign Language, PECS Board, and the Switch, communication becomes available for non-verbal learners. Throughout this presentation, we will demonstrate how to effectively operate each type of communication device and when a student might utilize them.https://digitalcommons.jsu.edu/ce_jsustudentsymp_2024/1058/thumbnail.jp
College Athlete Revenue Sharing and NIL: Financial Considerations and Implications
No full textThe landscape of college athletics has changed significantly over the past several years. Due to the ruling from the 2021 court case NCAA v. Alston, athletes are now allowed to earn compensation from their Name, Image, and Likeness (NIL). This compensation originates from external sources, such as collectives, donors, and companies, not the academic institutions themselves. The compensation received is determined by each athlete’s specific market/brand value. Social media has become a major factor in defining market value in the modern era of technology. The more “valuable” the athlete, the more likely for them to receive NIL income. However, there are issues that arise with this new stream of income. They may not realize the responsibilities attached to the new income stream they are receiving, especially the taxation rules that will apply to them. A dearth of tax education for student athletes currently exists. Many athletes do not have any substantial background in financial planning or financial literacy. Mandated guidelines by the NCAA are needed to aid these student athletes or individual institutions to navigate these new financial considerations.https://digitalcommons.jsu.edu/ce_jsustudentsymp_2024/1052/thumbnail.jp
Are Concussed Collegiate Athletes More Susceptible to Depression: A Critically Appraised Topic
No full textContext: The interdependent relationship between concussions and depression in collegiate athletes has become increasingly popular over the last few years. There is an estimated 1.6 to 3.8 million sport-related concussions annually in the United States, making it one of the leading public health problems. The United States Department of Health and Human Services states that depression is most prevalent in the 18-25 age group. The prevalence of the risk of depression in collegiate student-athletes ranges from 15.6-33.2%, with first-year students and females typically reporting more symptoms. The purpose of this critically appraised topic is to investigate if collegiate athletes are more susceptible to depression, after sustaining a concussion.
Methods: A computerized search was conducted in October 2023. The search terms used were “collegiate athletes”, “concussion”, and “depression”. Electronic databases used were JSU library, SPORT Discus, PubMed and Google Scholar. Inclusion criteria included: studies conducted with current collegiate athletes, peer-reviewed studies, articles published after 2000, and studies that reported data on mental health along with concussions. Exclusion criteria included: studies that included international sports, studies that solely talked about retired athletes, and studies that were in any language other than English. Validity of the selected studies was determined using the PRISMA and STOBE checklists. One author independently reviewed the studies, scored each paper, and reviewed the completed appraisals to come to a consensus on the study quality.
Results: The literature search retrieved 1,710 total articles and 1,707 articles were excluded based on the exclusion criteria, resulting in three studies. When researching the long-term effects of sport-related concussions, one article concluded that currently competing athletes and/or retired athletes displayed impaired mental health, particularly with depression symptoms. Sport-related concussions and mental health outcomes, studies concluded that depression symptoms were the most frequently considered and reported mental health outcome in concussion research. Furthermore, predictors and prevalence of post-concussion depression symptoms concluded that a large portion of collegiate athletes demonstrated an increase in depression after concussion.
Conclusions: The clinical bottom line demonstrates an association between concussion and depression. It is essential that athletic trainers and other healthcare professionals are aware of this connection to advocate for athletes that may experience depressive symptoms after a sport-related concussion. Future research should investigate other patient populations such as other professional sports and coping strategies in the management of depression.https://digitalcommons.jsu.edu/ce_jsustudentsymp_2024/1040/thumbnail.jp