97557 research outputs found
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Houston Cole Library Annual Report | January - December 2024
No full textThe Houston Cole Library Annual Report details Library collections, services, events, faculty activities, and more for the past calendar year.https://digitalcommons.jsu.edu/lib_ac_coletrain/1039/thumbnail.jp
Combination of HDAC and FYN Inhibitors in Synovial Sarcoma
No full textThe SS18-SSX fusion protein is an oncogenic driver in synovial sarcoma. At the molecular level, SS18-SSX functions as both an activator and a repressor to coordinate transcription of different genes responsible for tumorigenesis. Here, we identify the proto-oncogene FYN as a new SS18-SSX target gene and examine its relation to synovial sarcoma therapy. FYN is a tyrosine kinase that promotes cancer growth, metastasis and therapeutic resistance, but SS18-SSX appears to negatively regulate FYN expression in synovial sarcoma cells. Using both genetic and histone deacetylase inhibitor (HDACi)-based pharmacologic approaches, we show that suppression of SS18-SSX leads to FYN reactivation. In support of this notion, we find that blockade of FYN activity synergistically enhances HDACi action to reduce synovial sarcoma cell proliferation and migration. Our results support a role for FYN in attenuation of anti-cancer activity upon inhibition of SS18-SSX function and demonstrate the feasibility of targeting FYN to improve the effectiveness of HDACi treatment against synovial sarcoma
Revealing The Truth: Entry View 2
No full textDisplay of printed bookletshttps://digitalcommons.jsu.edu/etds_mfa_images/1151/thumbnail.jp
Basking in Abundance: Distribution and Abundance of Alabama Map Turtles (Graptemys pulchra) in the Upper Coosa River
No full textThe Alabama Map Turtle (Graptemys pulchra) is one of the least studied species of turtle in the United States. Little is known about the species distribution and abundance within the northeastern portion of its range. The aim of this study is to determine the distribution of G. pulchra in the Upper Coosa River drainage as well as estimate population sizes for G. pulchra at 6 sites accessible in the Upper Coosa River Drainage. I used a variety of methods (e.g., rapid assessment surveys, trapping, mark-resight population estimates) to determine the presence and abundance of the species in the Upper Coosa River of northeastern Alabama and northwestern Georgia. Graptemys pulchra was observed at 8 of the 62 total sites (12.9%) and was present in relative abundance at all 6 trapping sites. The species was in highest abundance at sites directly below major dams. Trapping yielded 119 total G. pulchra, along with two other species of map turtle, 2 native Northern Map Turtles (G. geographica) and 25 invasive Ouachita Map Turtles (G. ouachitensis). Graptemys pulchra was one of the most abundant species present in the Upper Coosa, even in highly degraded riverine habitats. I found a mean population estimate for G. pulchra (120.17 individuals/river kilometers) that is much higher than population estimates from other studies conducted historically or throughout other portions of its range. These data provide an important baseline for the species population across the Upper Coosa River which will allow for ongoing monitoring to ensure the continued success of G. pulchra throughout this portion of its range
Revealing The Truth: Book View 2
No full textOpened booklet viewhttps://digitalcommons.jsu.edu/etds_mfa_images/1155/thumbnail.jp
Revealing The Truth: Book View 5
No full textOpened booklet viewhttps://digitalcommons.jsu.edu/etds_mfa_images/1158/thumbnail.jp
JSU Financial Documents, Miscellaneous: Finding Aid
Get PDFThis collection is comprised of miscellaneous historical items related to Jacksonville State University finances. These include annual budgets, receipts, bond information, contract and other building paperwork, faculty salaries, invoices, and more
Exploring Minority Students’ Perceptions of Using Open Educational Resources in a Computer Game Design Course
No full textWith the increasing use of open educational resources (OERs) in higher education, and the potential of OERs to enhance student learning, this study investigated minority students’ perceptions of using OERs in learning computer programming. The influence of minority students’ OER perceptions on their learning outcomes, as well as the relationships of the perception variables were explored. The participants were minority students from an HBCU institution in the southeastern United States. Quantitative approaches were used to analyze the collected data. The results indicated that the minority students’ perceptions of using OERs had a significant influence on their perceived learning outcomes in learning computer programming. OER self-efficacy did not influence the minority students’ perceived learning for programming. Understanding of OERs, OER interest, and OER self-efficacy significantly predicted the minority students’ perceived value/usefulness of OERs in learning coding