Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
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A new micropterous species of the genus Sunius Stephens, 1829 from Central Anatolia (Coleoptera: Staphylinidae)
No full textSunius shavrinisp. n. is described from Ankara province in central Anatolia. While most of the TurkishSuniusspecies, especially all Turkish endemics are restricted to the mountains of western Anatolia and the Taurus mountains in southern Anatolia, the new species has been found in the northern part of Central Anatolia. Additional records of two species ofSuniusare reported from Turkey. The genus is now represented in Turkey by 42 species, 38 of which are endemic to Anatolia
Gingival crevicular fluid galectin-3 and interleukin-1 beta levels in stage 3 periodontitis with grade B and C
No full textObjectivesThis study aims to evaluate GCF Galectin-3 and Interleukin-1 beta (IL-beta) levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in periodontal diseases.Materials and methodsA total of 80 systemically healthy and non-smoker individuals, 20 stage 3 grade C (S3GC) periodontitis 20 stage 3 grade B (S3GB) periodontitis, 20 gingivitis, and 20 periodontally healthy were enrolled. Clinical periodontal parameters were recorded and GCF Galectin-3 and IL-1 beta total amounts were measured by ELISA. Receiver operating characteristics curve was used for estimating the area under the curve (AUC).ResultsGalectin-3 and IL-1 beta were detected in all participants. Both periodontitis groups had significantly higher GCF Galectin-3 total amounts than periodontally healthy controls (p <0.05). S3GC periodontitis group had also significantly higher GCF Galectin-3 levels than gingivitis group (p <0.05). GCF IL-1 beta levels in periodontitis groups were higher than gingivitis and periodontally healthy groups (p <0.05). Galectin-3 exhibited an AUC value of 0.89 with 95% sensitivity to discriminate S3GC periodontitis from periodontal health, an AUC value of 0.87 with 80% sensitivity to discriminate S3GC periodontitis versus gingivitis, while an AUC value of 0.85 with 95% sensitivity to discriminate S3GB periodontitis from healthy controls.ConclusionsGCF Galectin-3 levels are involved in the pathogenesis of periodontal diseases. Galectin-3 showed excellent diagnostic performances to discriminate S3GB and S3GC periodontitis from periodontal health and gingivitis
Comparison of contrast-enhanced T1-weighted and 3D constructive interference in steady state images for predicting outcome after hearing-preservation surgery for vestibular schwannoma
No full textWe compared contrast-enhanced T1-weighted and 3D constructive interference in steady state (CISS) sequences for demonstrating possible prognostic factors in hearing-preservation surgery for vestibular schwannoma. We studied 22 patients with vestibular schwannomas having hearing-preservation surgery. Postoperatively six (27%) had a facial palsy and eight (36%) had hearing loss. There was a significant correlation between the size of the tumour and facial palsy (r= -0.72). Both techniques adequately demonstrated all tumours. Involvement of the fundus of the internal auditory canal (IAC) and a small distance between the lateral border of the tumour and the fundus were correlated significantly with hearing loss (r= -0.81 and -0.75, respectively). The 3D-CISS sequence, by virtue of its high contrast resolution was superior to T1-weighted images (P<0.05) for detection of the fundal involvement. The direction of displacement of the facial nerve did not correlate with facial palsy or hearing loss. We think that 3D-CISS images better show the features influencing surgical outcome, but that contrast-enhanced T1-weighted images are required for diagnosis
International Business Cycle Spillover Effects and Counter-Cyclical Monetary Policy
No full textIn the first phase of this study the international spillover of economic fluctuations is investigated by Diebold and Yilmaz (2009) Spillover Index method. In the second stage of the study, the state asymmetry of the monetary policy has been tested by Markov Regime Switching method. According to the Spillover Index findings, 48% of economic shocks affecting the Turkey caused by external shocks. The economic fluctuations that occurred in Turkey are originated 12,5% from South Korea, 8.4% from US, 6.4% from Japan, 4.5% from Greece and 3.2% from the Spanish Economy. According to these results, the economic conditions of these countries are leading indicators for the Turkish Economy. Markov Regime Switching model findings show that Turkish Economy grows 1.82% on an average in the expansion, shrinks 3.38% on an average in the contraction and an increase in the exchange rate slows the economic growth in Turkey. Finally obtained econometric evidence shows that CBRT can bring real effect in expansion regime but not create real impact in the fight against recession
Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis
No full textDiabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene (PTS) (trans-3,5-dimethoxy-4-hydroxystylbene) has been reported to relieve oxidative stress and apoptosis in DM, but its role in diabetic-induced ototoxicity is unclear. This study aimed to investigate the effects of dose-dependent PTS on the cochlear cells of streptozotocin (STZ)-induced diabetic rats. The study included 30 albino male Wistar rats that were randomized into five groups: non-diabetic control (Control), diabetic control (DM), and diabetic rats treated with intraperitoneal PTS at 10, 20, or 40 mg/kg/day during the four-week experimental period (DM + PTS10, DM + PTS20, and DM + PTS40). Distortion product otoacoustic emission (DPOAE) tests were performed at the beginning and end of the study. At the end of the experimental period, apoptosis in the rat cochlea was investigated using caspase-8, cytochrome-c, and terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin end labeling (TUNEL). Quantitative real-time polymerase chain reaction was used to assess the mRNA expression levels of the following genes:CASP-3, BCL-associated X protein (BAX), andBCL-2. Body weight, blood glucose, serum insulin, and malondialdehyde (MDA) levels in the rat groups were evaluated. The mean DPOAE amplitude in the DM group was significantly lower than the means of the other groups (0.9-8 kHz; P DM + PTS10 > DM + PTS20 > DM + PTS40 > Control; P < 0.05 for all). PTS treatment also reduced cell apoptosis in a dose-dependent manner by increasing the mRNA expression of the anti-apoptosisBCL2gene and by decreasing the mRNA expressions of both the pro-apoptosisBAXgene and its effectorCASP-3and the ratio ofBAX/BCL-2in a dose-dependent manner (P < 0.05 compared to DM for all). PTS treatment significantly improved the metabolic parameters of the diabetic rats, such as body weight, blood glucose, serum insulin, and MDA levels, consistent with our other findings (P < 0.05 compared to DM for all). PTS decreased the cochlear damage caused by diabetes, as confirmed by DPOAE, biochemical, histopathological, immunohistochemical, and molecular findings. This study reports the first in vivo findings to suggest that PTS may be a protective therapeutic agent against diabetes-induced ototoxicity
NOTES ON THE SUBFAMILY PAEDERINAE OF ED?RNE PROVINCE IN TURK?YE. A NEW SPECIES OF THE GENUS Lathrobium Gravenhorst, 1802 WITH NEW AND ADDITIONAL RECORDS (INSECTA: COLEOPTERA: STAPHYLINIDAE)
No full textIn this study, as a result of field studies conducted in Edirne province in the Marmara Region of Turkiye between March 2021 and June 2022, totally 18 species in 11 genera belonging to the subfamily Paederinae (Coleoptera: Staphylinidae) were recorded. Field studies were conducted from different localities in Edirne Province by using aspirator and sifter methods. A new species of the genus Lathrobiuum Gravenhorst, 1802 Lathrobium gocmeni sp. n. (Edirne, Enez) is described illusturated and distinguished from congeners. Astenus thoracicus (Baudi di Selve, 1857), A. procerus (Gravenhorst, 1806), Lobrathium rugipenne (Hochhuth, 1851), Medon fusculus (Mannerheim, 1830), Micrillus testaceus (Erichson, 1840), Paederus littoralis, Gravenhorst, 1802, and Scopaeus gracilis (Sperk, 1835) from Thrace, and Lathrobium fulvipenne Gravenhorst, 1806 are reported for the first time from the Marmara Region. In addition, all 18 species except for Achenium propontiacum Bordoni, 2009 and Scopaeus laevigatus (Gyllenhal, 1827) were recorded for the first time from Edirne province
Synthesis and photophysical characterization of isoindigo building blocks as molecular acceptors for organic photovoltaics
No full textFive isoindigo-based donor-acceptor-donor (D-A-D) type small molecules have been synthesized in order to investigate their intramolecular charge transfer characteristics. UV-vis absorption of these dyes exhibits a wide absorption band ranging from 300 to 650 nm with two distinct bands, giving the narrow bandgaps between 1.72 and 1.85 eV. Taking into account their HOMO-LUMO energy levels and bandgaps, isoindigo dyes have been used in the active layer of organic solar cell (OSC) devices. When these small molecule semiconductors were used as acceptors with the donor poly(3-hexylthiophene-2,5-diyl (P3HT) polymer in the inverted OSC devices, the highest power conversion efficiency (PCE) was obtained as 0.10% for pyrene-substituted isoindigo derivative. (C) 2018 Elsevier B.V. All rights reserved
Lack of association between leptin levels and leptin gene polymorphism in obese women
No full textThe aim of the present study was to evaluate the relationship between oligopolymorphism in the 25th codon of leptin gene and obesity. Eighty-seven obese women and 75 healthy women were constituted obese and control groups. Body fat percent, fat mass and lean body mass were determined by bioimpedance meter and leptin levels were determined. The presence of 25th codon oligopolymorphism in the leptin gene was done by PCR-RFLP technique. Mean leptin levels were 38.5 +/- 22.0 ng/ml, and 147.9 +/- 44.8 ng/ml in the control and obese groups, respectively. The correlations of serum leptin level to body fat percentage and fat mass in the control group were significant. The correlations in the obese group were not significant. This data implies that the difference of leptin levels between control and obese groups are more likely to be associated with alterations in the leptin gene other than 25th codon or alterations in the leptin receptor gene
The role of CAPE in PI3K/AKT/mTOR activation and oxidative stress on testis torsion
No full textIschemia reperfusion injury arises from testicular torsion resulting in a loss of spermatogenesis and significant germ cell apoptosis. This study evaluates the prooxidant/antioxidant effects of caffeic acid phenethyl ester (CAPE) through PI3K/AKT/mTOR signal pathways on testis torsion. A total of (28) male Wistar rats were divided randomly into 4 groups (n = 7 for each group):group A (sham) group,group B torsion/detorsion group, group C (saturation group, during four days of CAPE, one dose (10 mu mol/kg, i.p)) and group D (a single dose of CAPE 2 h after torsion and before detorsion). At the end of the study, unilateral orchiectomies were performed for measurements of MDA and 8OHdG levels, histopathologic and immunohistochemical and TUNEL apoptotic cell examination. Testicular torsion-detorsion led to a significant decrease in the mean values of the Johnsen's scores and a significant increase in the apoptotic cell values of group B. There were no significant differences between group D and group A. In addition, the MDA and 8OHdG levels increased significantly in group B. The MDA and 8OHdG values were lower in group D. However, the 8OHdG levels were higher in group C than the groups A and D. On the other hand, CAPE suppresses mTOR activation and reduces the apoptosis on ischemia/reperfusion damage in rat testis. These results demonstrate that CAPE suppresses mTOR activation and reduces the apoptosis on ischemia/reperfusion damage in rat testis. (C) 2015 Elsevier GmbH. All rights reserved
Examining the level of knowledge and practices regarding the use of biologic agents among nurses working in oncology and hematology clinics at a university hospital
No full textOBJECTIVES This study aimed to examine the level of knowledge and practices of nurses responsible for the execution and management of cancer treatment in patients receiving biotherapy as related to the use of biological agents. METHODS This descriptive study was conducted with 40 nurses in oncology and hematology units of a university Medical Faculty hospital in which biological agents are frequently applied. RESULTS The majority of nurses (57.5%) were aged 23-27 years. It was determined that 35.5% of nurses obtained a patient history and 82.5% queried the allergic history of patients before biotherapy. According to the nurses' responses, 79.5% monitored the patients in terms of development of local complications, 85% informed the patients about complications, and 77.5% informed them about delayed infusion reactions. CONCLUSION Although the majority of nurses had not received a specific education about biotherapy, they were knowledgeable as related to the storage, preparation and administration of biological agents