Manisa Celal Bayar Üniversitesi Akademik Arşiv Sistemi
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Careers and Research Performance of PhD Program Graduates of Health Sciences in Turkey
No full textIn this review, we aimed to evaluate PhD graduates of the period between 1985-2010 and analyze the status, motivation and positive and negative factors influencing research motivation of graduates in eight disciplines from three graduate schools of Health Sciences in Turkey and to compare with the present status in the world. Some information obtained by web-based survey is the following: The most of graduates (83%) have academic positions in basic sciences departments in the faculty of medicine in universities. 94.2 % of graduates recognized the importance of personal motivation, while 54% of them thought that finding the appropriate research environment was important for research. For 52%, the biggest hindrance to medical research was lack of funding and for 39%, lack of technic personnel for research. The studies in the literature related to PhD graduates pointed out to the following facts: The number of PhD graduates is increasing gradually and the graduates' career choices have changed from academic to non-academic positions, especially in the industry. This is not parallel to our pilot study findings. About the teaching perspective treated in the relevant literature, the concept of one should be a good researcher, as well as a good teacher is dominant. PhD graduates in our pilot study mentioned that they had responsibilities in the education activities during their PhD education. We think that these responsibilities are useful for their future academic career. In conclusion, the majority (83%) of graduates from Graduate Schools of Health Sciences in Turkey are enrolled into academic researcher positions in universities. They keep producing funded research work as a first author and publish despite some problems
Evaluation of Property Right in Metaverse Land Purchases in terms of Islamic Law
No full textHuman beings constantly want to increase the value of their assets. Investing in real estate is seen as one of the most profitable investments in increasing the value of assets today. Land purchases in the metaverse have taken their place among the investments in demand in this sense. Land purchases in the virtual universe have brought questions that need to be answered legally. It can be said that it is essential to protect the right of the investor/user, especially since these plots are in the metaverse and that the entrance to this universe is de-pendent on the approval of the user agreement, and how these agreements define the ownership on these plots. In Islamic law, the delivery of the place of contract is one of the contract' validity conditions. This surrender is defined as the right of full disposal over the place of the contract. The fact that the full right of disposition on the lands in the meta universe is de-pendent on the platform's user agreement brings forward the questions that need to be answered about the nature of the transfer of ownership. On the other hand, for something to be legally the subject of property, it must be defined as a property. The consensus element in accepting something as property in Islamic law is that a value attribution is included in the social presupposition. For this, it is necessary to determine what the value attributed to the purchase and sale of the purchased land in the meta universe means in economic terms in the real world. In addition, in Islamic law, the location of the contract to be free from all kinds of uncertainty is one of the conditions that must be observed in order not to be deceived and deceived. For this reason, it can be thought that this uncertainty can be eliminated, at least for the buyer, by knowing the content of the user contracts to which the lands purchased with large sums are bound. For this reason, for these evaluations to be based on concrete data, the contract containing the terms of use of Sandbox, one of the prominent platforms in the purchase and sale of land in the meta universe, was taken as a basis. In this context, the limita-tions on the right of disposition determined by the user contracts on these lands have been evaluated within the framework of the principles that Islamic law takes as a basis for some-thing to be the subject of a contract
Askin tumors in children: A report of four cases
No full textPrimary malignant tumors of the chest are rare in the pediatric age group. Askin tumor belongs to the peripheral primitive neuroectodermal tumor family, and typically involves the periosteum, soft tissue and extrapulmonary tissue of the thoracic wall. We report our ten years experience with four cases of this rare tumor
Evaluation of sexual functions and marital adjustment of pregnant women in Turkey
No full textThe aim of this study was to evaluate pregnant women's sexual function and marital adjustment. The sample of the study included 298 women, and it was evaluated using Golombok Rust Inventory of Sexual Satisfaction (GRISS) Scale and Marital Adjustment Scale. The most important reasons for decreasing the frequency of sexual intercourse included the fear of harming the fetus during intercourse (62.1%), fear of having miscarriage (47.8%) and decreased sexual desire (34.7%). It was found that women with sexual dysfunction had a significantly lower educational level, were living with three or more people in their home, were multiparious, had an unplanned pregnancy, reported pain during sexual intercourse and felt that their sexual life was very affected during pregnancy. The findings of the study showed that women had >= 5 points for GRISS for the subscales as follows: infrequency (47.3%), non-communication (57.4%), dissatisfaction (15.4%), avoidance (6.4%), non-sensuality (19.1%), vaginismus (28.9%), anorgasmia (29.9%) and sexual dysfunction (17.4%). In conclusion, women who were living with three or more people at home, had lower income level, were smoking and had an unplanned pregnancy scored under 43.5 of MAS. It was found negative and there was a medium correlation between MAS score and total GRISS score
Infections in children with left ventricular assist device
No full textBackground There are limited data about pediatric left ventricular assist device (VAD) infections in developing countries. This study aimed to investigate device postimplantation infectious complications and their pathogenic profile. Methods Data were analyzed from patient charts involving 27 patients with dilated cardiomyopathy who underwent left VAD implantation at a leading tertiary care center in Turkey. Results The study included 17 boys and ten girls with a median age of 12.22 years (range 17 months to 18 years). Nineteen patients were diagnosed with idiopathic, and three were diagnosed with familial dilated cardiomyopathy. Twenty-two out of 27 subjects (%81.48) developed 80 infection episodes in total. The most common type of left VAD-specific infection was the exit site of the driveline. Infected patients with left VAD had a significantly prolonged hospitalization compared with the patients without infection (P = .014). Infection-induced pediatric intensive care unit (ICU) admission was higher in patients with fungal infection(P = .023). Gram-positive staphylococci were the most commonly isolated bacterial pathogens, followed by Gram-negative bacteria. Five patients developed fungal infections. None of the fungal infection patients underwent transplantation(P = .035). Seven deaths occurred in our study group. All deaths were in the infected group. Mortality was associated with the presence of multidrug-resistant Gram-negative bacterial infections (P = .015), an increased number of infection episodes (P = .003), and hospitalization due to infection (P = .003). Conclusion Ventricular assist device-related infections were frequent among our study patients. The predominantly isolated agents were Gram-positive bacterial pathogens. However, the emergence of relatively high rate of Gram-negative bacterial and fungal infections was associated with mortality before the transplantation. Establishing local programs for surveillance data, controlling for infection rates, and antibiotic stewardship are essential to reduce mortality of VAD patients in developing countries
Protective Effect of Spirulina on Cisplatin-Induced Ototoxicity: A Functional and Histopathological Study
No full textObjective: The purpose of this study was to evaluate the protective effect of an antioxidant and anti-inflammatory agent, spirulina, against cisplatin-induced ototoxicity in rats. Methods: Twenty-eight adult Sprague-Dawley rats were divided into 4 groups. Before drug administration, distortion product otoacoustic emission and auditory brainstem response tests were performed. Group 1 (n =7) received 1 mg of intraperitoneal saline. Group 2 (n=7) received a single dose of intraperitoneal cisplatin at 15 mg/kg/day. Group 3 (n=7) received oral spirulina at 1000 mg/kg/day for 10 days. Group 4 (n=7) received a single i.p. dose of cisplatin at 15 mg/kg/day, followed by 10 days of oral spirulina at 1000 mg/kg/day. The final distortion product otoacoustic emission and auditory brainstem response measurements were provided 10 days after the initial drug administration. Cochleas were removed, the histochemical examination was performed by caspase-3, caspase-9, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling methods. Results: Initially, there were no significant differences in distortion product otoacoustic emission and auditory brainstem response measurements between groups. Following cisplatin treatment, the mean difference in signal to noise ratio values was lower in the cisplatin + spirulina group compared to the cisplatin-only group. The increase in auditory brainstem response thresholds was more significant in the cisplatin-only group than in the cisplatin + spirulina group. Posttreatment auditory brainstem response latencies were prolonged in cisplatin and cisplatin + spirulina groups; however, a significant difference was obtained between these 2 groups. The cisplatin + spirulina group had a lower density of apoptotic cells than the cisplatin-only group. Conclusion: Spirulina has no adverse effects on cochlear functions and may provide some protection against cisplatin-induced ototoxicity
Traumatic spinopelvic dissociation managed with bilateral triangular osteosynthesis: Functional and radiological outcomes, health related quality of life and complication rates
No full textBackground: Spinopelvic dissociation (SPD) is difficult to manage and is associated with high mortality and morbidity, including concomitant orthopaedic polytrauma, spine injuries, pelvic ring disruptions, neurological, soft-tissue, and vascular injuries. The purpose of this study is to evaluate the functional and radiological outcomes; health related quality of life and complication rates of patients with traumatic spinopelvic dissociation underwent bilateral triangular osteosynthesis (TOS). Methods: The study was approved by the medical school's institutional review board (IRB). Prospective data collection of nineteen consecutive cases of traumatic SPD were included in the study from October 2015 to August 2018. Bilateral TOS was performed to manage all patients with SPD. The clinical outcome for fractures was analyzed with Majeed function assessment. Health Related Quality of Life (HRQoL) was assessed with the EQ-6D questionnaire. The reduction quality was evaluated according to Matta criterion. CT scanning was used to verify the fracture union in patients at 24th weeks postoperatively. Results: There were 12 women and 7 men with an average age of 47.2+8.4 years (range, 17-62 years). The average follow-up time was 25.2 +/- 3.7 months (average, 22-45 months). The most common mechanism of injury was falling (57%). According to Majeed functional scoring, the results were excellent in 12 cases, good in 5 cases and fair in 2 cases. The median EQVAS score was 78.9 +/- 8.4. 15 patients (78.9%) turned back to their original occupation. Pain and mood disorders mainly influenced patients' present general health status. According to Matta criterion for fracture reduction, the results were excellent in 14 cases, good in 4 cases and fair in 1 case. Complications were noted as wound healing problems (26%), implant loosening (5%) and iatrogenic nerve injury (5%). Conclusion: Bilateral TOS demonstrates satisfactory functional and radiological outcomes with low complication rates except infection rate in patients with traumatic spinopelvic dissociation. HRQoL is mainly dominated by pain and mood disorders. 78.9% of the patients turned back to their original occupation. Surgeons should be aware of wound healing problems in case of increased muscle mobilization and degloving injuries.Implant removal is required to improve the lumbopelvic mobility. (C) 2020 Elsevier Ltd. All rights reserved
PREDICTORS OF NEW-ONSET ATRIAL FIBRILLATION AFTER ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE ELDERLY
No full textObjective: The predictors and outcomes of new-onset atrial fibrillation (AF) were evaluated among elderly patients with acute ST elevation myocardial infarction (STEMI). Material and Method: Patients with STEMI who are older than 65 years were evaluated for new-onset AF and its complications. Patients with a previous history of AF and those found in AF at the time of admission were excluded. Results: Of the 102 patients with STEMI, AF was not observed in 74 patients (Group I) and was observed in 28 patients (Group II) during hospitalization. Those 28 patients with AF were further divided into two subgroups according to the onset time of AF (early 24 hours). Anterior MI was observed in 49% of patients in Group I and 71.4% of patients in Group II (p<0.05). In late onset AF group; pulse rate, systolic and diastolic blood pressure were significantly higher than Group I at admission to the hospital (p<0.05). All patients in Group II had higher Killip class and TIMI risk scores than Group I patients (p<0.05). Left ventricular ejection fraction was 30.4 +/- 4.0% in the late onset group and 44.4 +/- 8.8% in Group I (p<0.05). There was a significant difference in mortality rate among groups during hospitalization period; 36% in Group II, 9% in Group I (p<0.05). Conclusion: AF is especially seen in elderly female patients with anterior MI and higher Killip Class. It is associated with higher rates of in-hospital mortality. Particularly, late-onset AFs are associated with lower LVEFs in older patients with STEMI and could be predictors of in hospital mortality