International Journal of Research in AYUSH and Pharmaceutical Sciences (IJRAPS)
Not a member yet
130 research outputs found
Sort by
PHARMACOGNOSTIC STUDY OF GOMPHRENA SERRATA STEM
No full textObjective: To analyze the pharmacognostic characteristics and physiochemical parameters of the stem of Gomphrena serrata (G. Serrata).
Methods: Micro, as well as macroscopic characteristics, were investigated. Physicochemical parameters had been done by implementing WHO suggested parameters; preliminary phytochemical and fluorescent evaluation of stem was executed for appropriate identification and standardization.
Results: The color, shape, size, odor, and surface characteristics were reported from the stem and powdered stem material of G. serrata. Light microscope images of cross section and powdered stem revealed the presence of multicellular uniseriate trichomes, lignified xylem fibers, xylem vessels and parenchyma cell. Phytochemical testing confirmed the presence of alkaloids, carbohydrates, saponins, tannins, proteins, amino acids, phytosterols, and flavonoids. Physicochemical parameters such as moisture content, ash value, extractive value and fluorescent behavior of stem powder have also been established
Conclusion: The current research would be useful in order to supplement the information regarding standardization, identity and in performing additional explorations in Ayurvedic system of medicine
PHYTOCHEMICAL AND PHARMACOLOGICAL OVERVIEW OF ACEROLA CHERRY: A REVIEW
Get PDFThis review paper is focused on phytochemical and pharmacological overview of Acerola cherry. It is native to tropical and subtropical America. It is a small cherry like fruit and is often referred to as the Barbados, the West Indian, or the Puerto Rican cherry. This review has been conducted to update the information that is available in different scientific literatures. It is observed that the fruits of Acerola cherry are the rich source of Vitamin C and also contains phytochemicals such as anthocyanidin, carotenoids and polyphenols. These components exhibit various pharmacological activities like Free radical scavenging activities and inhibitory effects on both alpha-glucosidase and advanced glycation end products (AGEs) production. It is used as an antioxidant, antimicrobial agent and antihyperglycaemic agent. The Present review article can act as database for the phytochemical and pharmacological activities for future prospect and research
REVIEW OF CONCEPT OF PAIN MANAGEMENT IN AYURVEDA
Get PDFIn spite of very advanced researches in Science, Pain still remains the major cause of disability affecting the large number of population in the world. An integrated approach towards Pain Management should possibly answer the grief involved in treating this Symptom of varying degrees. Even Ministry of AYUSH, India has stressed upon this alarming topic and professed its theme as “Pain Management through Ayurveda” for Second National Ayurveda Day.
In this article, review of the classical text with special references to pain, and its management through Ayurvedic procedures such as Snehan, Swedan, Agnikarma, Jalaukaavcharan, Vedhankarma, Lepankarma & Bastikarma has been discussed in context to their utility in Pain management. Similarly, The role of Madhur-Amla-Lavan Rasa Aushadhi in Pain management due to Dhatukshayjanya Vataprakopa in view of G-PCR bio-signalling of taste and Pain modulation is also incorporated to explain role of palliative medicines
IN VITRO ANTI OXIDANT ACTIVITY OF CHROMATOGRAPHICALLY SEPARATED FRACTIONS FROM THE LEAVES OF AGERATUM CONYZOIDES L
Get PDFSynthetic anti oxidants are not safe for human health. It is often claimed that they may develop carcinoma in human body. Therefore, search for natural anti oxidants was going on and extended up to plant sources. Many medicinal plants are known having anti oxidant activity. Aageratum conyzoides Linn. is one such plant. In order to isolate anti oxidant compound (s) from the leaves of A. conyzoides L. the present study was undertaken. In isolation study silica gel G column chromatography of the powdered leaves of A.conyzoides L. was done when six fractions were separated. In vitro anti oxidant activity of these six fractions was measured by superoxide anion generation with help of xanthine-xanthine oxidase assay and with linoleic acid peroxidation assay as well as DPPH photometric assay. Results showed that fourth fraction had maximum anti oxidant activity. Inhibitory activities of xanthine oxidation, linoleic acid peroxidation and scavenging capacity of DPPH by the fourth fraction were respectively 96%, 97% and 96% whereas for other five fractions inhibitory activities were quite low.
Anti oxidant activity is known to be associated with compounds like total phenol, flavonoids, ascorbic acid and carotenoids. These compounds were estimated in the separated six fractions after chromatography of powdered leaves of A. conyzoides L. Results showed that fourth fraction had total phenol, flavonoids, ascorbic acid and carotenoids in the concentrations of 58 mg/mg dry wt, 88 mg/mg dry wt, 22 mg/g dry wt and 25 mg/g dry wt respectively. The amounts were significantly higher in comparison to that of other fractions. In vitro anti oxidant activity of the fourth fraction was, therefore, related with high amounts of total phenol, flavonoids, ascorbic acid and carotenoids. Present study indicated that the separated fourth fraction after silica gel G column chromatography of powdered leaves of A.conyzoides L. may be used as natural anti oxidant
DEVELOPMENT AND STANDARDIZATION OF HEALTH STATUS ASSESSMENT TOOL BASED ON AYURVEDIC PARAMETERS W.S.R TO DATHU SAMYA LAKSHNA
No full textBackground: Dathu Samya Lakshana are the criteria to know physical and mental well being in Ayurveda. The contemporary science has standardized health assessment questionnaire which is based on the health parameters told by WHO. We get many references for the features of healthy person in Ayurveda, but no standardized questionnaire for health assessment has been worked out so far. This study was planned with the objective to develop, validate and standardize a questionnaire to assess improvement in health status based on Ayurvedic Parameters. Materials and Methods: A qualitative research that involved interview method and simple random sampling. The prepared questionnaire was distributed to 250 apparently healthy subjects and their response was documented. Tables of frequency and percentage were framed on the basis of responses to individual items. Suitable statistical methods were used for analysis. Results: Cronbach’s alpha value for two domains viz., physical health and mental health values are 0.936, and 0.725 respectively and over all alpha value was 0.942. The KMO values for the two domains were 0.605 and 0.610 respectively indicating sampling adequacy. Conclusion: The questionnaire can be used as a tool to assess health status according to Ayurveda and thus fulfils the gap
A RANDOMISED SINGLE BLIND ACTIVE CONTROLLED, PARALLEL GROUP STUDY COMPARING THE EFFICACY & SAFETY OF THE KARNIM PLUS® CAPSULES IN PATIENTS WITH MILD OR MODERATE DIABETES MELLITUS TYPE. II
Get PDFDiabetes is the most prevalent disease in the world affecting middle and old aged persons of the world directly impacting their life style and other metabolic hazards. Karnim plus is a remedy of Unijules Life Sciences ltd. And current multicentric, randomized, single blind, active controlled and parallel group with metformin capsule clinical study is conducted in two centres of Dr. D.Y. Patil College and Ashwin Ayurved college respectively. Total 121 patients were treated according to the previously approved protocol from institutional ethics committee for the treatment period of 24 weeks in a dose of 2 capsules BID before meal and primary efficacy parameters set to HbA1c, fasting and post meal blood sugar. From the study it was concluded that Karnim plus capsule and Metformin capsule are equally effective in controlling hyperglycemia with slightly more time to achieve significance result in Karnim plus. In case of HbA1c highly significant results were observed in Karnim plus capsule and also highly significance is observed in symptom score of clinical parameters. Cholesterol levels are significantly decreased in Karnim plus group than metformin group. This indicated that Karnim plus is effective remedy in controlling diabetes type II with no any adverse effects and controlling metabolism in a effective way than other OHA
ROLE LATAKARANJA VATI IN THE MANAGEMENT OF POLYCYSTIC OVARIAN SYNDROME: A CASE STUDY
No full textThis is a case study of Latakaranja in PCOS. PCOS (Polycystic Ovarion Syndrome) is heterogeneous disorder of unknown etiology affecting 5 to 10% women of reproductive age group. It is the disorder that affect the reproductive, endocrine and metabolic system. Also it is most common cause of infertility. Ayurvedic treatment of PCOS is specific to the individual. In majority of women with PCOS, there is a strong Kapha component. They often struggle with mysterious weight gain i.e., hard to lose even while maintaining light diet, healthy lifestyle and regular exercise. According to Ayurveda Latakaranja is Laghu, Ruksha, Ushna veeryatmaka and Kaphavatghna. A female pt of 23 years old was diagnosed with PCOS on the basis of clinical features and USG findings. This study was carried out on O.P.D. basis. Latakaranja vati of 500 mg. twice daily after meal with Koshna jala for 6 months. After three months complaints of pt like irregular, scanty menstrual bleeding, lower abdominal pain got reduced. It can be concluded that Latakaranja can be used for regulation of menstrual cycles and other complaints in PCOS
EFFICACY OF PATRAPINDA SWEDA AND MATRA BASTI (COMBINED THERAPY) IN THE MANAGEMENT OF SANDHIVATA (OSTEO ARTHRITIS)
Get PDFAccording to WHO Sandhivata is the second commonest musculoskeletal problem in the world after backache. The present clinical trial was conducted to evaluate the efficacy of Ptrapinda Sweda and Matra Basti (combined Chikitsa) in the management of Sandhivata.
Total 30 patients were selected for clinical trial. All the 30 patients were treated with Patrpinda Sweda for first 8 days and Vatanashak tail Matra basti for next 8 days. Results were assessed according to a standard grading system for Shool, Graha, Sparshasahatva and Shotha. Functional impairment was assessed by observing walking time. There was complete relief of Shool in 36.6%, Sparshasahatva in 43.3% and Graha in 43%. Significant improvement was observed in Shotha and in walking time. Marked improvement was observed in Shool in 40%, Sparshasahatva in 33.3% and Graha in 40%.
Hence it is concluded from the study that the combination of Patrpinda sweda and Matra Basti is a reliable management of Sandhivata, which should be repeated at least 6 monthly to maintain the symptomless state
PRELIMINARY PHYTOCHEMICAL, PHARMACOGNOSTIC AND PHYSICOCHEMICAL EVALUATION OF ERANTHEMUM NIGRUM LEAF
Get PDFObjective: To analyze the pharmacognostic characteristics and physiochemical parameters of the leaves of Eranthemum nigrum (E. nigrum).
Methods: Microscopic characters and powder analysis had been carried out with the help of a microscope. The physiochemical properties such as loss on drying, total ash value, acid insoluble ash value, water soluble ash value, extractive values and fluorescence of E. nigrum had been performed.
Results: Macroscopically, the leaves are simple, elliptical in shape, dull with smooth margins and acute apex. Microscopically, the leaf showed the presence of epidermal cells with uniseriate multicellular covering trichomes and diacytic stomata, followed by 4-6 layered collenchymatous cells and 10-14 numbered conjoint, collateral closed vascular bundles are some of the diagnostic characteristics observed from an anatomical study. Powder microscopy of leaf revealed the presence of uniseriate multicellular covering trichomes, lignified xylem vessels, epidermis with diacytic stomata and parenchyma cells. The investigations also included leaf surface data i.e., quantitative leaf microscopy and fluorescence analysis. Physiochemical parameters such as loss on drying, extractive values and ash values were also determined. Preliminary phytochemical screening showed the presence of steroids, alkaloids, tannins, saponins, carbohydrates, glycosides, amino acids and proteins.
Conclusion: The morphological, microscopical and physicochemical parameter results provided in this paper may be utilized as a basis for the preparation of a monograph on E. nigrum leaves
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ANALYSIS OF CEPHALEXIN AND BROMHEXINE IN PHARMACEUTICAL DOSAGE FORM
Get PDFA simple, precise and rapid RP-HPLC method has been developed and validated for the simultaneous determination of Cephalexin and Bromhexine in pharmaceutical dosage form. The method was carried out using Kromasil C8 column (250 mm x 4.6 mm, 5µm) and mobile phase comprised 0.1% Ortho Phosphoric Acid (OPA) and acetonitrile in the ratio of 45:55 v/v and degassed under ultrasonication. The flow rate was 1.0 mL/min and the effluent was monitored at 215 nm. The retention times of Cephalexin and Bromhexine were 2.29 min and 2.81 min respectively. The method was validated in terms of linearity, precision, accuracy, specificity, limit of detection and limit of quantitation. Linearity was in the range of 62.5 to 375 µg/mL for Cephalexin and 1 to 6 µg/mL for Bromhexine respectively. The percentage recoveries of both the drugs were ranging from 98.27 to 100.02% for Cephalexin and 98.17 to 99.32% for Bromhexine respectively from the tablet formulation. The proposed method is suitable for the routine quality control analysis of simultaneous determination of Cephalexin and Bromhexine in bulk and pharmaceutical dosage form