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Le travail émotionnel des enseignants lors de projets éducatifs dépassant la leçon d'EPS
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Using the Critical Incident Tecchnique to explore situational emotional in sport psychology
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Polygenic Risk Scores: A Hidden Risk of Lower Urinary Tract Symptoms?
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AGS : garantie des créances résultant d’une prise d’acte ou d’une résiliation du contrat de travail: Observations sous Cass.soc, 8 janvier 2025, n°20-18.484, B et Cass.soc., 8 janvier 2025, n°23-11.417, B
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Charge de la réparation du préjudice d'anxiété en cas de transfert d'entreprise: Observations sous Cass.soc, 29 avril 2025, n°23-20.501, B
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A language-parametric test amplification framework for executable domain-specific languages
No full textInternational audienceBehavioral models are important assets that must be thoroughly verified early in the design process. This can be achieved with manually-written test cases that embed carefully hand-picked domain-specific input data. However, such test cases may not always reach the desired level of quality, such as high coverage or being able to localize faults efficiently. Test amplification is an interesting emergent approach to improve a test suite by automatically generating new test cases out of existing manually-written ones. Yet, while ad-hoc test amplification solutions have been proposed for a few programming languages, no solution currently exists for amplifying the test suites of behavioral models. In order to fill this gap, we propose an automated and generic test amplification approach for executable Domain Specific Languages (DSLs). Hence, given an executable DSL, a conforming behavioral model, and an existing test suite, our approach synthesizes new regression test cases in three steps: (i) generating new test inputs by applying a set of generic modifiers on the existing test inputs; (ii) running the model under test with new inputs and generating assertions from the execution traces; and (iii) selecting the new test cases that increase the initial test quality. We provide a textual DSL to control and configure the amplification process, along with tool support for the whole approach atop the Eclipse GEMOC Studio. For assessment, we report on empirical evaluations over two different executable DSLs, which show improved test quality in terms of both coverage and mutation score
Preventing unplanned extubations: A test bench simulation comparing endotracheal tube securing techniques in acute care settings
No full textInternational audienceBackground: Effective securing of the endotracheal tube (ETT) after inserting is essential to prevent unplanned extubation (UE). This study compared six ETT securing techniques and a no-device control in resisting to simulated UE, assessing performance across different traction speeds (slow and fast) and planes (frontal and sagittal).Method: A mechanically ventilated mannequin was used. Extubation, defined as a sudden loss of airway pressure, was induced using a tensile testing machine. The required force to cause extubation (forceextubation) was recorded. For each combination of securing technique, traction speed and traction plane, five measurements of forceextubation were collected. Techniques included three cord-based, two elastic adhesive tape-based, one commercial device (AnchorFast™, Hollister), and a control with no securing method.Results: In the sagittal plane, AnchorFast™ required significantly higher forceextubation (median 75 N [IQR: 52-86]) compared to adhesive tape methods (short: 28 N [19-34], p < 0.001; long: 34 N [24-45], p = 0.026). Cord-based techniques performed similarly to the AnchorFast™. The control setup (i.e., without any securing device) and the elastic adhesive tape showed comparable forceextubation levels which were also significantly lower than that of a single cord with a knot. In the frontal plane, forceextubation was higher than in the sagittal plane (115 N [89;148] and 44 N [26;57], respectively, p < 0.001), and no significant differences were observed between techniques.Conclusion: ETT securing techniques using elastic adhesive tape were less effective at preventing simulated UE than either the AnchorFast™ device or a single cord with a knot
Prognostic Value of Venous-to-Arterial pCO₂ gap During Cardiopulmonary Bypass for Predicting Cardiac Surgery-Associated Kidney Injury: A Bicentric Retrospective Study
No full textInternational audienceBackground: Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most frequent and severe complications after cardiac surgery. The association between acute kidney injury and the mismatch between oxygen consumption and delivery has been well established during cardiopulmonary bypass (CPB). In this study, we aim to explore the prognostic value of the central venous-to-arterial pCO2 gap during CPB to predict CSA-AKI.Methods: Bicentric retrospective study conducted in two teaching hospitals. All patients who underwent cardiac surgery requiring CPB in two periods between 2019 and 2023 were screened for inclusion. Patients were divided into 2 groups according to the presence or absence of an elevated pCO2 gap during CPB, which was defined as greater than 6 mmHg. The primary outcome was the occurrence of CSA-AKI.Results: Among 318 patients included, 213 were in the low pCO2 gap group and 105 in the elevated pCO2 gap group. No significant difference in CSA-AKI occurrence was found between groups (32.4% vs. 23.8%; p = 0.14). pCO2 gap was not a good predictor of CSA-AKI, with an area under the curve for the ROC curve of 0.63 (p = 0.87). Except for SVO2 during CPB, we did not find any correlation between pCO2 gap and other tissue perfusion parameters during or after CPB.Conclusion: We did not find any association between the presence of an elevated pCO2 gap during CPB and the occurrence of CSA-AKI. This may suggest that a single intraoperative measurement of pCO2 gap is not a reliable marker of persistent tissue hypoperfusion in this context
Safety and efficacy of a dexamethasone-sparing regimen with daratumumab and lenalidomide in patients with frailty and newly diagnosed multiple myeloma (IFM2017-03): a phase 3, open-label, multicentre, randomised, controlled trial
No full textInternational audienceBACKGROUND: Patients with frailty and newly diagnosed multiple myeloma have worse outcomes due to higher rates of adverse events (AEs) and treatment discontinuation. This study evaluated a dexamethasone-sparing regimen of daratumumab plus lenalidomide versus lenalidomide plus dexamethasone in frail patients with newly diagnosed multiple myeloma.METHODS: In this prospective, randomised, open-label trial, conducted at 61 active Intergroup Francophone of Myeloma centres, patients aged 65 years or older with newly diagnosed multiple myeloma and an Eastern Cooperative Oncology Group proxy frailty score of 2 or more were randomly assigned 2:1 to receive daratumumab (1800 mg subcutaneously) plus oral lenalidomide (25 mg daily for 21 days of a 28 day cycle) and dexamethasone (20mg weekly) for two cycles (dexamethasone-sparing group) or lenalidomide (25 mg daily) and oral dexamethasone (20 mg weekly; control group), with stratification by International Staging System, age, and centre. The primary endpoint was progression-free survival. Efficacy was assessed in the intention-to-treat population and safety was assessed in all patients exposed to at least one dose of randomised intervention. This trial is registered with ClinicalTrials.gov, NCT03993912, and is complete.FINDINGS: From Oct 18, 2019 to July 20, 2021, 335 patients were screened, of whom 295 patients were randomly assigned (200 to lenalidomide plus daratumumab, 95 to lenalidomide plus dexamethasone). The median age was 81 years (IQR 77-84), with 180 (61%) aged older than 80 years, and 151 (51%) patients were female and 144 (49%) were male. Median follow-up was 46·3 months (IQR 46·0-52·7). Median progression-free survival was 53·4 months (95% CI 35·3-not reached) in the dexamethasone-sparing group versus 22·5 months (16·5-39·0) in the control group (hazard ratio [HR] 0·51, 95% CI 0·37-0·70, p<0·0001). The most common grade 3-5 AEs were neutropenia (110 [55%] of 200 patients in the dexamethasone-sparing group vs 23 [24%] of 95 patients in the control group), and infection (38 [19%] vs 20 [21%]). Serious adverse events occurred in 126 patients (63%) in the dexamethasone-sparing group and 66 patients (69%) in the control group. AEs leading to death occurred in 23 patients (12%) in the dexamethasone-sparing group and 12 patients (13%) in the control group, with 4 (2%) and 2 (2%) grade 5 treatment-emergent adverse events, respectively.INTERPRETATION: In the IFM2017-03 trial, use of lenalidomide plus daratumumab, with dexamethasone limited to the first 2 treatment cycles, reduced the risk of progression or death compared with lenalidomide plus dexamethasone, with no additional safety concerns. Lenalidomide plus daratumumab could therefore be considered as a treatment option for older patients with frailty and newly diagnosed multiple myeloma. FUNDING: The study was funded by Johnson and Johnson
Ultrasound-Assisted Extraction of Inorganic Elements and Antioxidants from Gingerbread Cookies Using Natural Deep Eutectic Solvents
No full textInternational audienceIn the present study, ultrasound-assisted extraction using deep eutectic solvents was proposed for the preparation of uniced and iced gingerbread cookies prior to the determination of four macronutrients (potassium, sodium, magnesium, calcium), four micronutrients (manganese, zinc, iron, copper), the presence of toxic metal (cadmium), and antioxidant capacity. With the addition of 30% water in each green solvent, three acidic deep eutectic solvents, comprising xylitol with malic acid, choline chloride with malic acid, and choline chloride with lactic acid, were tested for their efficiencies in the simultaneous extraction of elements and antioxidants. The synthesized deep eutectic solvents were characterized by infrared spectroscopy, which provided evidence of generating new hydrogen bonds between two components of these solvents. Element profiles were analyzed by inductively coupled plasma-mass spectrometry after the extraction using green solvents and the microwave-assisted acid digestion of gingerbread samples. It was found that two deep eutectic solvents containing malic acid exhibited high abilities for solubilization of macronutrients and manganese from the samples studied, while the best extraction efficiencies for Zn, Fe and Cu micronutrients were achieved when the lactic acid-based deep eutectic solvent was used. However, the antioxidant capacity, evaluated by 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and cupric reducing antioxidant capacity (CUPRAC) methods, led to the selection of choline chloride-lactic acid as the most promising green solvent for extracting antioxidants from two types of gingerbread cookies. The deep eutectic solvent-based extraction conforms to the principles of green chemistry and is suitable for releasing elements and antioxidants from gingerbread cookies