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Daytime and nighttime heatwave intensity and acute care utilization for mental and neurological disorders in California
No full textInternational audienceHeatwave exposures have been linked to a variety of mental and neurological disorders. Little is known, however, about the potentially differential associations of daytime versus nighttime heatwave intensity with subtypes of mental and neurological disorders. In this time-stratified case-crossover study, we estimated and compared the associations of typically dry daytime and typically humid nighttime heatwave intensities, characterized by heatwave indices (HWIs), with acute care utilizations for various subtypes of mental and neurological disorders in 1412 ZIP Code Tabulation Areas in California from 2006 to 2019. A total of 4309 294 acute care utilizations for mental disorders and 2097 563 for neurological disorders were included in this study. Higher associations with nighttime HWI were found for most disease subtypes, including anxiety disorder, depressive disorder, schizophrenia, bipolar disorder, post-traumatic stress disorder, Alzheimer’s disease and related dementias, and Parkinson’s disease; while daytime HWI showed a higher impact on conduct disorders (P < .001). On average, during the warm season in California, nighttime heatwaves accounted for about 70.6% and 34.0% of acute care utilizations for mental and neurological disorders that were attributable to heatwaves, respectively. Our findings highlight the detrimental impacts of humid nighttime heatwaves on mental and neurological health and call for innovative heat preparedness actions and increased awareness among public health practitioners as more nighttime heatwaves are anticipated under climate change
La résolution de problèmes en Sciences expérimentales : regards croisés sur les pratiques enseignantes en Europe
No full textInternational audienceCet article propose une analyse comparative de pratiques d'enseignement de la résolution de problèmes en sciences expérimentales au niveau secondaire supérieur en France, aux Pays-Bas et en Italie. Cette étude de cas s’appuie sur des observations en travaux pratiques et convoque trois cadres d'analyse : les fonctions du problème selon Fabre, des éléments de la Théorie Anthropologique du Didactique (praxéologie) et le modèle des connaissances professionnelles des enseignants (PCK). Le but est de modéliser et de comparer les choix pédagogiques (praxis) et les savoirs mobilisés (logos) par les professeurs dans différents contextes institutionnels européens
Proceedings of the AI WILD West 2026
No full textInternational audienceArtificial Intelligence Workshop on Inverse problem, Learning, imaging & Data science in the West (AI WILD West) aims to bring together researchers working at the interface of inverse problems, artificial intelligence, and applied mathematics. The workshop focuses on methodological advances and their applications in translational research, imaging and data science. By fostering interactions between theory and practice, the workshop encourages cross-disciplinary exchanges between mathematics, machine learning, and application-driven research communities
Reframing Sustainable Consumption: Toward an Ethical Dilemma Perspective
No full textInternational audienceThis conceptual study explores consumers’ ethical dilemmas inherent in the domain of sustainable consumption. The tra-ditional approach to sustainable consumption tends to exclude individual interests and consumer well-being, implicitly assuming that sustainable consumption should be entirely altruistic and devoid of personal benefits. Using the triple bottom line framework adapted to the consumer level, we argue that, in addition to addressing social and environmental concerns, sustainable offerings should integrate self-profit as an equally important concern. From this perspective, sustainable con-sumption inherently entails dilemmas, as social, environmental, and individual benefits may conflict with one another. In this research, we propose examining sustainable consumption through the lens of ethical dilemmas, to shed light on the tensions involved in navigating these multifaceted issues. We identify nine types of ethical dilemmas related to sustainable consumption and illustrate them with concrete scenarios to demonstrate the applicability of our proposed classification. This study sets the stage for future research by highlighting key areas in which additional investigations are required to deepen understanding of ethical dilemmas and develop practical solutions for fostering sustainable consumption
HARCOM: Hardware complexity model for microarchitecture exploration
No full textInternational audienceMicroarchitecture exploration is generally conducted with performance simulators written in general-purpose programming languages, often C++. A performance simulator does not need to simulate all the details of the hardware implementation. It is often sufficient to simulate the events that can impact performance significantly, such as cache misses, branch mispredictions, data dependences, etc. Performance simulators often use approximations and abstractions. This is what allows them to simulate the execution of many instructions in a short amount of time, which is important for estimating millisecond-scale performance and for design space exploration.In general, microarchitects try to simulate realistic mechanisms. However, assessing the hardware complexity of a mechanism which only exists as a piece of C++ code in a performance simulator can be difficult. Hardware complexity is a multidimensional quantity including silicon area, energy consumption and delay. A simple, oft-used estimate of hardware complexity is the amount of storage used by a mechanism. Nevertheless, there is more to hardware complexity than storage. For instance, the delay of a branch predictor depends not only on its storage but also on the logic circuits processing the stored information. On the one hand, some hardware complexity models are available for microarchitecture research, such as CACTI and McPAT. However, their applicability is limited to cache-like structures or fixed microarchitectures. On the other hand, electronic design automation tools can be used to implement the hardware. However, this requires too much time and effort for microarchitecture exploration.HARCOM is a C++ library for estimating approximately the hardware complexity of microarchitectural parts, such as caches, branch predictors, hardware prefetcher, etc. HARCOM is compatible with existing performance simulators that are written in C++. HARCOM tries to find a useful middle ground between several contradictory objectives: the accuracy of the hardware complexity model, simulation speed, flexibility and ease of use. The microarchitectural part under study is modeled with HARCOM values instead of C++ integers. HARCOM simulates the functional behavior and, simultaneously, provides estimates of the silicon area, number of transistors, dissipated energy and circuits delays
Copyright claims and revenue allocation on streaming platforms
No full textThis paper examines how to allocate the revenue generated by content creation on streaming platforms when creators may hold overlapping copyright claims over the work of others. We develop a stylized model of such environments and propose the Equal Rights allocation rule. We provide two axiomatic characterizations of this rule based on principles directly relevant to our setting. Using a cooperative game-theoretic approach, we define content creation games that capture revenue generation under copyright constraints. We show that the Equal Rights rule always produces Core-stable allocations, while maintaining properties that set it apart from the Shapley value
A new zinc(II) pyrazine-porphyrin complex for dual drug and heavy metal sensing: Structural and electrochemical insights
No full textInternational audienceWe present the synthesis and comprehensive characterization of a novel zinc(II) metalloporphyrin, formulated as [Zn(TCF3PP)(pyzi)] (complex I), where TCF3PP is the meso-tetrakis(para-trifluoromethylphenyl)porphyrinate and pyzi is pyrazine. Notably, we detail its spectroscopic characterization using UV/Vis, infrared, and 1H NMR techniques, along with single crystal X-ray diffraction and Hirshfeld surface analysis, establishing the molecular architecture of complex I. The electrochemical properties were assessed through cyclic voltammetry, demonstrating the complex's capability to be immobilized on a screen-printed gold electrode (SPCE) for sensor applications. This modified electrode exhibited exceptional electrochemical performance in detecting ciprofloxacin (CIP) and hazardous heavy metal ions such as Pb2+ and Cd2+, showcasing superior sensitivity and selectivity. Our findings underscore the innovative use of pyrazine-coordinated zinc(II) porphyrin as a promising platform for multifunctional electrochemical sensing applications
L’Écoute s’il Pleut: Enquête sur des formes d’anticipation auditive
No full textInternational audienceL’Écoute s’il Pleut. Enquête sur des formes d’anticipation auditive est une interrogation théorique et esthétique de l’écoute de phénomènes météorologiques à partir de l’archéologie du toponyme L’Écoute s’il Pleut. Cette appellation provient du nom porté par une quarantaine de lieux qui, à travers la France, sont souvent associés à la présence d’un moulin à eau situé sur un ruisseau à faible débit (« il semble attendre la pluie pour fonctionner »). Mais il s’agit également d’une expression qualifiant une personne distraite, se fiant à de vaines promesses ou des espoirs mal-fondés. À partir de cette double définition, et d’autres encore, qui, selon leur acception toponymique et figurative, apparaissent dès le XIIIe siècle, le texte développe un éventail de formes d’écoute qui comportent une attente, parfois accompagnée d’une anxiété, face aux phénomènes météorologiques, en particulier les différentes natures de pluie. Ces formes sont analysées en sept chapitres à travers les personnages de quelques productions littéraires ou cinématographiques qui sont à l’écoute des sons de la pluie à venir. Sont mis en résonance certains développements de la météorologie, principalement depuis le début du XIXe siècle, et des théories de l’écoute relevant des sound studies, de la musicologie, ou de la théorie des médias et de la philosophie. Conjointement à la référence à des écrits sur l’émergence de la rationalisation du temps qu’il fait, l’attention est portée sur les pratiques mantiques et divinatoires des Anciens et leur évocation dans des textes sur l’écoute. Cette enquête est le lieu de rencontres entre chercheurs ayant vécu au XIXe siècle – notamment Luke Howard, Adolphe Quetelet et Robert Fitzroy et les protagonistes des romans Walden (1854) de Henry David Thoreau – récit autobiographique – et Présence de la mort (1922) de Charles Ferdinand Ramuz, ainsi que les personnages des films Take Shelter (2011) réalisé par Jeff Nichols et Memoria (2021) réalisé par Apitchatpong Weerasethakul. L’Écoute s’il Pleut porte ainsi sur la perception du temps qu’il fait et du temps qu’il fera, et plus précisément sur différentes expériences auditives de ce qui n’a pas encore eu lieu
Filamin a binds deleted in liver cancer 1 (DLC1) to promote its tumor suppressor activity and inhibit the SRF coactivator MRTF-A
No full textInternational audienceFilamin A (FLNA) is an actin binding protein that organizes the cytoskeleton and controls many fundamental biological processes, such as cell migration and adhesion. The interaction between FLNA and the Myocardin-related transcription factor A (MRTF-A) promotes the activity of serum response factor (SRF) and cell migration. MRTF-A and SRF play an important role for tumor growth and senescence of hepatocellular carcinoma (HCC). Here, we identified a novel interaction between FLNA and the tumor suppressor Deleted in Liver Cancer 1 (DLC1) in vitro and in vivo in organoids and mapped the regions of interaction between DLC1 and FLNA. Association with FLNA enhanced DLC1 RhoGAP function, impaired SRF transcriptional activity, and induced cellular senescence. We found a novel molecular switch between the DLC1-FLNA and the MRTF-A-FLNA complexes that is mediated by FLNA phosphorylation at serine 2152. We generated DLC1 binding peptides that dissociate the MRTF-A-FLNA complex and favor the novel DLC1-FLNA complex by preventing actin polymerization and FLNA phosphorylation at serine 2152. Since FLNA phosphorylation at serine 2152 was increased in mouse xenografts, reinforcing the DLC1-FLNA complex by targeting FLNA phosphorylation at serine 2152 represents a promising therapeutic approach for HCC treatment