Bartin University Institutional Repository
Not a member yet
12212 research outputs found
Sort by
Nursing Care in Acute Renal Failure After the Diagnosis of Congestive Heart Failure According to Gordon's Functional Health Patterns Model: A Case Report
No full textCongestive heart failure; it is characterized by the inability of the heart to pump blood to the periphery that cannot meet its metabolic needs. Increases in the workload of the heart occur due to deterioration of myocardial performance, dysrhythmias and filling defect in the heart. Complaints seen in congestive heart failure; shortness of breath, weakness, edema in the feet and legs, and cough. In the case, a 66-year-old female patient was admitted to the hospital with the complaint of shortness of breath. As a result of the examinations, she was diagnosed with congestive heart failure and admitted to the ward. In this process, the patient was evaluated according to the Functional Health Patterns Nursing Model and nursing care was given
Indanone-based Mannich bases: Design, synthesis, in-silico molecular docking, ADME predictions and biological evaluation including carbonic anhydrases, acetylcholinesterase inhibition and cytotoxicities
No full textThis study examined the rational design, synthesis, carbonic anhydrases (CAs), acetylcholinesterase (AChE) inhibitory effects, and cytotoxicity of 2-(2-hydroxy-3-(aminomethyl))benzylidene)-2,3-dihydro-1H-inden-1-one (1-6) and 2-(2-hydroxy-3,5-bis(aminomethyl))benzylidene)-2,3-dihydro-1H-inden-1-one (7-11). All compounds exhibited significant inhibitory activity against hCA I, hCA II, and AChE enzymes. Among them, compound 9 demonstrated potent inhibition of hCA I (Ki = 46.828 f 11.32 nM) and AChE (Ki = 0.9820 f 0.402 nM), while compound 11 showed strong inhibition against hCA II (Ki = 24.683 f 6.216 nM). For comparison, the reference compound acetazolamide (AZA) inhibited hCA I and hCA II with Ki values of 183.390 f 19.71 nM and 104.60 f 27.60 nM, respectively. Regarding AChE inhibition, the reference drug Tacrine exhibited a Ki value of 58.85 f 12.1 nM. These results indicate that compound 9 is significantly more potent than AZA against hCA I and markedly outperforms tacrine in inhibiting AChE. Similarly, compound 11 shows superior inhibitory activity compared to AZA against hCA II. The compounds' cytotoxicity against four human oral squamous cell carcinoma (OSCC) cell lines was compared to that of three normal oral cells. The compound 3, 2-(2-hydroxy-3-(piperidin-1ylmethyl)benzylidene)-2,3-dihydro-1H-inden-1-one, stood out for its promising selectivity in cytotoxicity, demonstrating the highest SI (9.5 toward HSC-2), TS1 (4.8), and PSE (4.8) compared to other studied compounds. Compound 3 showed 5-fold higher tumor specificity than 5-FU when using epithelial normal (human oral keratinocyte) and four human OSCC cell lines. Molecular docking results demonstrated that molecule 9 exhibited a strong binding affinity to AChE (-12.3 kcal/mol) with a remarkably low inhibition constant (Ki = 0.963905 nM), suggesting its potential as a potent inhibitor despite the absence of conventional hydrogen bonding. Conversely, molecule 11 showed enhanced selectivity toward hCAII, forming two hydrogen bonds and displaying a binding affinity of 10.4 kcal/mol. These findings indicate that both molecules possess promising inhibitory potential and can serve as valuable candidates for further experimental validation. Overall, this study highlights the effectiveness of molecular docking as a predictive tool in drug discovery and supports the further development of these lead compounds for therapeutic applications. SAR-based structural changes of compounds 3, 9, and 11 have the potential to generate novel, highly effective molecules, providing alternative treatments for a wide range of therapeutic areas, including cancer and neurological illnesses
Nuri Bilge Ceylan Sinemasında Toplumsal Cinsiyet: Kış Uykusu Üzerinden Nitel Bir İnceleme
No full textSosyolojik çözümlemelere konu olabilecek sinema filmleri, sahip oldukları geniş kitlelere ulaşma potansiyeliyle toplumsal cinsiyetin inşası, yeniden üretimi ve temsili süreçlerinin incelenmesinde önemli bir kültürel üretim alanı olarak öne çıkmaktadır. Bu doğrultuda yürütülen bu araştırma, Nuri Bilge Ceylan’ın Kış Uykusu adlı filmi üzerinden toplumsal cinsiyet olgusunu irdelemeyi amaçlamaktadır. Bu araştırmada, nitel araştırma yöntemlerinden biri olan doküman analizi kullanılmış; Toplumsal Cinsiyet Olgusu İnceleme Formu aracılığıyla filmdeki karakterlerin meslek tercihleri, mekânsal konumlanmaları, gündelik yaşam pratikleri ve kişilik özellikleri gibi temalar üzerinden toplumsal cinsiyet rollerine ilişkin temsiller sistematik biçimde incelenmiştir. Filmde kadın karakterlerin karar alma mekanizmalarından büyük ölçüde dışlanan, toplumsal ve mekânsal hareket alanları kısıtlanmış bireyler olarak temsil edildiği; buna karşın erkek karekterlerin güç, otorite ve entelektüel üstünlük gibi nitelikler etrafında yapılandırılarak daha baskın ve merkezi rollerle konumlandırıldığı belirlenmiştir. Bu araştırma, toplumsal cinsiyet algısının sinema yoluyla nasıl inşa edildiğini ve yeniden üretildiğini tartışarak, toplumsal cinsiyet olgusuna dair farkındalık yaratmayı hedeflemektedir
Investigation of Electrocatalytic Applications of Various Advanced Nanostructured Alloys-An Overview
No full textCyclic voltammetry (CV) is one of the advanced techniques used to determine various bioactive molecules, organic dyes, pesticides, veterinary drugs, heavy metals, toxic chemicals, etc. To determine all the above analytes, one needs an electrocatalyst for their electrochemical redox reaction. Many researchers have reported the use of metal nanomaterials, metal oxide nanomaterials, metal-organic frameworks, surfactants, polymers, etc., as modifiers in carbon paste electrodes to enhance their current response, stability, sensitivity, and repeatability. But some of the emerging, cost-effective, and highly efficient electrocatalysts are advanced nanostructured alloy powders. These advanced alloys are used as a modifier to determine various bioactive analytes. These alloy-modified carbon paste electrodes (MCPEs) show excellent selectivity, sensitivity, and stability due to their extraordinary electrochemical properties, as the compositional elements of most of the alloys belong to d-block elements in the periodic table, and these transition elements are famous for their brilliant electrocatalytic properties. The present review article mainly focuses on the determination of dopamine, AA (AA), uric acid, methylene blue, methyl orange, Rhodamine B, and the L-Tyrosine amino acid by various alloys like stainless steel, high-entropy alloys, and shape-memory alloys and how these alloys could change the perception of metallurgists and electrochemists in the future. These alloys could be potential candidates for the development of various electrochemical sensors because of their high porosity and surface areas
An example of a suitability analysis supported by Geographic Information Systems in the evaluation of agricultural production-oriented urban production landscapes: Bartın
No full textRapid population growth in cities has raised the necessity of taking measures regarding resource use. Especially during the COVID-19 pandemic, this necessity reminded society that the agricultural sector is one of the most crucial sectors for the future. In this study, suitable agricultural areas within the municipal boundary of Bart & imath;n province were identified using Geographic Information Systems (GIS) and the Analytic Hierarchy Process (AHP). Based on interviews with 15 experts, various factors such as land use type, slope, aspect, soil groups, land capability classes, and erosion risk were evaluated, and suitability maps were created. The findings indicate that 53.04% of the agricultural land within the municipal boundary is classified as highly suitable, 24.43% as suitable, and 22.45% as less suitable or not suitable. The suitability of public spaces (public areas, active and passive green spaces, healthcare facilities, places of worship, and educational areas) and arable lands was also analyzed. Among public spaces, 1.09% were classified as not suitable, 22.30% as less suitable, 66.22% as suitable, and 10.40% as highly suitable. In this context, it is argued that public spaces possess physical characteristics suitable for agricultural activities and can be considered production-oriented areas that enhance urban resilience
The effect of foot reflexology on pain intensity, sleep quality and bowel functions in patients undergoing appendectomy surgery
No full textBu araştırma apandisit nedeniyle apendektomi ameliyatı geçirmiş hastalarda ayak refleksolojisinin ağrı şiddeti, uyku kalitesi ve bağırsak fonksiyonları üzerine etkisini değerlendirmek amacıyla yapıldı. Araştırmanın evrenini, akut apandisit nedeniyle apendektomi ameliyatı geçiren 178 hasta oluşturdu. Araştırmanın örneklemi ise G power 3.1.9.7 programında güç analizi yapılarak ?=0,05, 0,60 etki büyüklüğü, %90 power ile toplam örneklem sayısı 120 olarak belirlendi. Ameliyat sonrası süreçte hastalar bilgisayar destekli program ile ikili blok randomizasyon uygulanarak müdahale (n=60) ve kontrol (n=60) grubuna ayrıldı (www.randomizer.org). Araştırmaya katılmayı kabul eden ve dahil edilme kriterlerine sahip apendektomi ameliyatı geçiren hastalar ile araştırma yürütüldü. Veriler; hasta tanılama formu, Visual Analog Skala, Richard Campbell Uyku Anketi ve Bağırsak Fonksiyonları İzlem Formu ile toplandı. Müdahale grubunda hastaların ilk olarak hasta tanılama formu aracılığı ile bilgileri kaydedildi. Ayak refleksolojisi yapılmadan hemen önce ağrı şiddeti değerlendirildi. Ameliyattan sonra 1. saatte ve 3. saatte hastanın her bir ayağına 10 dakika olmak üzere toplamda 20 dakika refleksoloji uygulandı. 1. ve 3. saatte her bir ayak refleksolojisinin uygulanmasından 5, 30 ve 60 dakika sonra hastaların ağrı şiddeti ölçüldü. Uygulamadan 24 saat sonra da hastaların uyku kalitesi ve 24 saat içerisindeki bağırsak fonksiyonları, ilk analjezik gereksinimi duyduğu zaman değerlendirildi. Kontrol grubuna ayak refleksolojisi yapılmaksızın aynı zaman diliminde ölçümler yapıldı. Her iki grupta 24 saat sonra uyku kalitesi, 24 saat içerisindeki bağırsak fonksiyonları ve ilk analjezik gereksinimi duyduğu zaman değerlendirildi. Verilerin değerlendirilmesinde tanımlayıcı istatistiksel yöntemleri olarak sayı, yüzde, ortalama, standart sapma kullanıldı. Bağımsız gruplarda kategorik değişkenlerin oranları arasındaki farklar Ki-Kare testleri ile analiz edildi. Normal dağılım gösterdiği tespit edilen veriler bağımsız gruplar t-testi, bağımlı gruplar t-testi, tekrarlı ölçümler ANOVA testi, tamamlayıcı Bonferroni testi ve ANCOVA testi ile analiz edildi. Araştırmada, ağrı düzeylerinin müdahale grubunda uygulamadan sonra zamanla azalma eğilimi gösterdiği, bu durumun özellikle üçüncü saat sonrası ölçümlerde belirgin hale geldiği, buna karşın kontrol grubunda arttığı tespit edildi (p<0,001). Tekrarlı ölçümler ANOVA sonuçları, ağrı düzeylerinin zaman içinde anlamlı şekilde değiştiğini ve bu değişimin grup etkisine bağlı olduğunu gösterdi (Fb=351,014 ve 105,707; p=0,000). Bonferroni çoklu karşılaştırma sonuçları da ağrı düzeylerinin uygulamadan hemen sonra hızlı şekilde azaldığını ve müdahale grubunda bu azalmanın daha güçlü olduğunu (?²=0,856 müdahale, ?²=0,642 kontrol) gösterdi. Müdahale grubundaki hastaların Richard Campbell Uyku Anketi ortalama toplam puanlarının (83,200±9,271), kontrol grubundan (65,717±13,128) anlamlı derecede daha yüksek olduğu saptandı (t=8,426; p=0,000). Gruplar arasında ilk gaz çıkış zamanı (t=1,076; p=0,284) ve defekasyon yapma zamanı (t=2,237; p=0,064) açısından istatistiksel anlamlı farklılık saptanmadı. Bu araştırma apendektomi ameliyatı geçiren hastalarda ameliyat sonrası erken dönemde uygulanan ayak refleksolojisinin hastaların ağrı düzeyleri ve uyku kaliteleri olumlu etkisi olduğunu, buna karşın barsak fonksiyonları üzerine etkisinin olmadığını gösterdi. Anahtar kelimeler: Ağrı, apendektomi, ayak refleksolojisi, bağırsak fonksiyonları, hemşirelik, uyku kalitesiThis study aimed to evaluate the effect of foot reflexology on pain intensity, sleep quality, and bowel function in patients who underwent appendectomy for appendicitis. The study population consisted of 178 patients who underwent appendectomy due to acute appendicitis. The sample of the study was determined as 120 with ?=0.05, 0.60 effect size, 90% power by performing power analysis in G power 3.1.9.7 programme. In the postoperative period, the patients were divided into intervention (n=60) and control (n=60) groups by applying double block randomisation with a computer-aided program (www.randomizer.org). The study was conducted with patients who agreed to participate in the study and who had appendectomy surgery with the inclusion criteria. Data were collected using a patient identification form, the Visual Analogue Scale, the Richard Campbell Sleep Questionnaire (RSCQ), and the Bowel Function Monitoring Form. In the intervention group, the information of the patients was first recorded by means of a patient identification form. Pain intensity was evaluated just before foot reflexology was performed. Reflexology was applied to each foot of the patient for 10 minutes at the 1st hour and 3rd hour after the operation, for a total of 20 minutes. At the 1st and 3rd hours, the pain intensity of the patients was measured 5, 30, and 60 minutes after the application of each foot reflexology. 24 hours after the application, the patients' sleep quality and bowel functions within 24 hours and the time they first needed analgesics were evaluated. The control group was measured at the same period without foot reflexology. Sleep quality, bowel function within 24 hours, and the time of first analgesic requirement were evaluated in both groups after 24 hours. Number, percentage, mean, and standard deviation were used as descriptive statistical methods in the evaluation of the data. Chi-square tests analysed differences between the rates of categorical variables in independent groups. Data that were found to be normally distributed were analysed by independent groups t-test, dependent groups t-test, repeated measures ANOVA test, complementary Bonferroni test, and ANCOVA test. In the study, it was determined that pain levels tended to decrease over time after the application in the intervention group, and this situation became especially evident in the measurements after the third hour, while it increased in the control group (p<0.001). Repeated measures ANOVA results showed that pain levels changed significantly over time and that this change was due to the group effect (Fb=351.014 and 105.707; p=0.000). Bonferroni multiple comparison results also showed that pain levels decreased rapidly immediately after the application and this decrease was stronger in the intervention group (?²=0.856 intervention, ?²=0.642 control). The mean total Richard Campbell Sleep Questionnaire scores of the patients in the intervention group (83.200±9.271) were found to be significantly higher than those of the control group (65.717±13.128) (t=8.426; p=0.000). There was no statistically significant difference between the groups in terms of the time of first flatulence (t=1.076; p=0.284) and time to defecation (t=2.237; p=0.064). This study showed that foot reflexology applied in the early postoperative period to patients undergoing appendectomy surgery had a positive effect on the patients' pain levels and sleep quality, but had no effect on bowel functions. Keywords: Appendectomy, bowel function, foot reflexology, nursing, pain, sleep qualİt
Analyzing Academic Achievement and Overconfidence in Database Management Systems Course: A Case Study of Computer and Instructional Technology Education Students
No full textDecision-making tends to be more accurate and of higher quality when there's a sensible harmony between self-confidence and actual capabilities. Overconfidence makes it difficult to set realistic goals in academic settings and increases the likelihood of facing failure. In this study, the academic achievements and overconfidence of students enrolled in the Database Management Systems course were examined. The research also aimed to determine whether there is a difference between midterm and final exams in terms of these variables. The participants were comprised of students enrolled in the Computer and Instructional Technologies Education department of a state university throughout the 2021-2022 academic year. The results indicated that approximately two-thirds of the students did not achieve satisfactory academic scores. Students struggled to accurately assess their exam performances, and a significant number of them overestimated their positions in both the midterm and final exams. Furthermore, there was no significant change between the midterm and final exams for any of the three factors
The Effect of STEM Applications on Mathematics Achievement: A Meta-Analysis Study
No full textThis study aims to determine the effect of STEM applications on mathematics achievement using the meta-analysis method. For this purpose, postgraduate theses in Türkiye were analysed. As a result of the review, 25 postgraduate theses related to the topic were initially identified, and data from 14 theses that met the inclusion criteria were included in the meta-analysis. Data analyses were carried out using the Comprehensive Meta-Analysis statistical program. While applying the meta-analysis method, homogeneity test was performed by calculating the effect sizes of the studies. Since the studies showed a heterogeneous structure as a result of the homogeneity test, the random effects model was used to calculate the overall effect size. Hedges's g coefficient was used to determine the effect sizes. Funnel plot and Rosenthal's safe N statistic were used to examine publication bias. The classification of Thalheimer and Cook (2002) was used to interpret the effect sizes obtained as a result of the analyses. In the study, it was determined that the effect sizes of all studies included in the meta-analysis were positive. Only two of the studies had a small effect, while the other studies showed at least a medium effect. The overall effect size value for mathematics achievement was found to be 0.901. Based on these results, it can be said that STEM activities have a positive and large effect on increasing mathematics achievement
The relationship between recreational sport well-being and academic belonging among university students
No full textBu araştırmanın amacı, üniversite öğrencilerinin rekreasyonel spor iyi oluş ve akademik aidiyetini çeşitli demografik değişkenlere göre incelemek ve değişkenler arasındaki ilişkiyi test etmektir. Araştırma grubunun evrenini, 2023-2024 akademik yarıyılında Bartın Üniversitesi, Spor Bilimleri Fakültesinde öğrenim gören 874 öğrenciden kolayda örneklem yöntemine göre seçilen 509 öğrenci oluşturmuştur. Araştırmada genel tarama modellerinden ilişkisel tarama modeli kullanılmıştır. Araştırmada veri toplama aracı olarak "Rekreasyonel Spor İyi Oluş Ölçeği (RSİOÖ)" ve "Akademik Aidiyet Ölçeği (AAÖ)" kullanılmıştır. Verilerin analizinde bağımsız örneklem t-Testi, tek yönlü ANOVA ve Pearson korelasyon analizleri kullanılmıştır. Araştırma bulgularının, yaş ve haftalık rekreatif etkinliğe katılma değişkeni korelasyon testi sonuçlarına göre RSİOÖ ve AAÖ alt boyutlarında anlamlı ilişki tespit edilmiştir. Katılımcıların cinsiyet değişkeni t-Testi sonuçlarına göre AAÖ "Derse Katılım, Kütüphane ve Kaynak Erişimi" alt boyutunda anlamlı farklılık tespit edilirken diğer alt boyutları ile RSİOÖ ve alt boyutları arasında anlamlı farklılık tespit edilmemiştir. Katılımcıların bölüm, serbest zaman yeterliliği ve aile gelir hissiyatı değişkeninin ANOVA testi sonuçlarına göre RSİOÖ ve AAÖ alt boyutları arasında anlamlı fark bulunmamıştır. RSİOÖ ve AAÖ arasındaki ilişkiyi tespit etmek amacıyla yapılan korelasyon analizine göre alt boyutların tamamı birbirleriyle düşük, orta düzeyde ve pozitif yönde ilişki bulunmuştur. Sonuç olarak rekreasyonel spor etkinliklerine katılımın bireylerin psikolojik, sosyal ve fiziksel iyi oluş düzeylerini artırarak akademik aidiyet duygusunu güçlendirdiği söylenebilir. Üniversite öğrencilerin serbest zamanlarını yapılandırılmış rekreasyonel faaliyetlerle değerlendirmeleri, akademik ortamla daha güçlü bir bağ kurmalarına, kurumsal kimlikle özdeşleşmelerine ve eğitim süreçlerine daha aktif katılım sağlamalarına katkıda bulunabilir. Anahtar Kelimeler: Akademik aidiyet, rekreasyonel spor iyi oluş, üniversite öğrencileri.The aim of this study is to examine university students' recreational sports well-being and academic belonging in relation to various demographic variables and to test the relationships among these variables. The population of the research group consists of 874 students enrolled in the Faculty of Sport Sciences at Bartın University during the 2023-2024 academic semester. A sample of 509 students was selected using the convenience sampling method. In the study, the relational survey model, one of the general survey models, was employed. In the study, the "Recreational Sports Well-Being Scale (RSWBS)" and the "Academic Belonging Scale (ABS)" were used as data collection instruments. In the analysis of the data, an independent samples t-test, one-way ANOVA, and Pearson correlation analyses were utilized. The findings of the study indicate significant relationships in certain sub-dimensions of the RSWBS and ABS based on the correlation test results for the variables of age and weekly participation in recreational activities. According to the t-test results for the gender variable of the participants, a significant difference was found in the "Class Participation, Library and Resource Access" sub-dimension of the ABS, while no significant differences were detected in the other sub-dimensions of the ABS or in the RSWBS and its sub-dimensions. According to the ANOVA test results for the participants' department, leisure-time competence, and perceived family income variables, no significant differences were found among the sub-dimensions of the RSWBS and ABS. According to the correlation analysis conducted to determine the relationship between the RSWBS and ABS, all sub-dimensions were found to have low to moderate positive correlations with each other. In conclusion, it can be stated that participation in recreational sports activities enhances individuals' psychological, social, and physical well-being, thereby strengthening their sense of academic belonging. Engaging in structured recreational activities during their leisure time may contribute to university students establishing a stronger connection with the academic environment, identifying with institutional identity, and participating more actively in the educational process. Key Words: Academic belonging, recreational sport well-being, university students
The First Chalcone Derivatives of Valine-Based Spiro-Cyclotriphosphazenes: In Vitro Cytotoxic Properties, Molecular Docking and DNA Damage Mechanism Studies
No full textCancer treatment requires novel compounds with potent cytotoxic and genotoxic properties to effectively target cancer cells. In this study, new hybrid cyclotriphosphazene compounds were synthesized, characterized, and evaluated for their biological activity. Cytotoxicity against A2780 and Caco-2 cancer cell lines was assessed via the MTT assay, while genotoxic effects at 60-70% cell viability were examined using the Comet assay. Apoptotic cells were identified through TUNEL analyses, and reactive oxygen species levels were measured. Results showed that these compounds significantly reduced cell viability through DNA damage mechanisms. At high doses (50-100 mu M), BV, BVK1, BVK2, and BVK4 decreased A2780 cell viability by 30-65%, whereas VPA had a milder effect (15-25%). In Caco-2 cells, viability was reduced by 10-35%. The compounds exhibited varying cytotoxicity across different cancer cell lines, reflecting cancer cell heterogeneity. Significant DNA damage, including changes in tail length, tail density, and tail moment, was observed in A2780 cells, confirming cell death via DNA damage. Molecular docking analyses further supported the potential of cyclotriphosphazene compounds (BV and BVK2) as targeted cancer inhibitors. Molecular docking revealed BVK2's high selectivity for Bcl-2, mutant p53, and VEGFR2. BVK2 and BV demonstrate strong binding affinities with key cancer-related targets, indicating their potential as multi-targeted inhibitors that regulate apoptosis, cell cycle control, and angiogenesis, making them promising candidates for targeted cancer therapy.Scientific and Technical Research Council of Turkiye (TUBITAK) [122Z060]This study was supported by a grant from the Scientific and Technical Research Council of Turkiye (TUBITAK, Grant Number: 122Z060)