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Effects of Home-Based Exercise Program on Chemotherapy-Induced Peripheral Neuropathy and Quality of Life: A Single-blind Randomized Controlled Trial
No full textBackground Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent symptom that negatively affects quality of life. Exercise is a beneficial intervention for managing peripheral neuropathy; however, insufficient evidence remains in this regard. Objective To evaluate the efficacy of a home-based exercise program in reducing the severity and symptoms of CIPN and improving quality of life. Methods This randomized controlled trial included 72 participants (intervention: n = 37, control: n = 35), with data collected from September 2020 to August 2022. The intervention group followed a home-based exercise program twice daily for 8 weeks, whereas the control group received standard care. Peripheral neuropathy severity was measured using Common Terminology Criteria for Adverse Events, whereas symptoms and quality of life were assessed using the European Organization for Research and Treatment of Cancer Chemotherapy-Induced Peripheral Neuropathy Quality-of-Life Questionnaire and the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire. Results Peripheral neuropathy symptom scores were significantly lower in the intervention group than in the control group at 8 weeks postintervention (P <.001). The effect size for sensory and motor neuropathy scores was large (d = 3.47 and d = 2.76, respectively). Quality-of-life scores were significantly higher in the intervention group than in the control group postintervention (P <.001), with a large effect size (?2 = 0.45). Conclusion A home-based exercise program reduced the severity and symptoms of CIPN and improved quality of life. Implications for Practice A home-based exercise program with sensory, strengthening, and balance exercises can be integrated into patient care as a nursing practice to improve CIPN symptoms and quality of life. © 2025 Elsevier B.V., All rights reserved
Novel triazole bridged quinoline-anthracene derivatives: synthesis, characterization, molecular docking, evaluation of electronic and enzyme inhibitory properties
No full textTwo novel quinoline-anthracene conjugates comprising styrylquinoline and anthracene moieties linked by triazole bridges were designed and synthesized in good yields. These molecules were determined for some metabolic enzymes activities. Results indicated that the synthetic molecules exhibited powerful inhibitory actions against all aims as compared to the control molecules. K-i values of novel compound QA-1 for hCA I, hCA II, AChE, and alpha-glycosidase enzymes were obtained of 20.18 +/- 2.46 mu M, 14.63 +/- 1.14 mu M, 71.48 +/- 7.76 nM, 401.35 +/- 36.84 nM, respectively. Both compounds showed promising candidate complexes for drug development with considerable in vitro different enzymes inhibitory activities. The binding conformations patterns and interaction of QA-1 and QA-2 compounds with alpha-glucosidase, acetycholinesterase, carbonic anhydrase-I and carbonic anhydrase-II enzymes were investigated through molecular docking profiles. The docking outputs are consistent with the Ki and IC50 values of novel compounds. Three dimensional geometries and electronic properties of the title compounds were obtained by the applicational computational approach at B3LYP/6-31++G(d,p) level of theory.We are grateful to the Turkish Scientific and Technical Research Council for the Grant (No. 118Z421). [118Z421]; Turkish Scientific and Technical Research CouncilWe are grateful to the Turkish Scientific and Technical Research Council for the Grant (No. 118Z421)
Source identification and quantification of real-world PAH contributions from traffic-related exhaust and non-exhaust emission sources using the EFECT method
No full textProper identification of sources and their contribution to atmospheric gaseous and particle-bound PAHs from traffic-related sources are vital for controlling and reducing emissions in the urban atmosphere to improve environmental health. For this purpose, we used the EFECT method to quantify the PAH contributions from the pre-defined vehicular sources, namely, road dust resuspension, exhaust (tailpipe), and non-exhaust sources in a rural highway tunnel. We successfully quantified the relative source contributions of particle-bound and total PAHs (particulate plus gaseous PAHs) to the atmospheric concentrations. Study results showed that exhaust emissions were observed to be the most important emission source for both particle-bound and total PAHs. This study showed that exhaust emission sources contribute 92.4% of IcdP, 90.3% of Phe, 89.9% of AN, 89.1% of BkF, 88.2% of Np, 87.1% of Ane, 86.3% of DahA, 85.7% of BghiP, and 82.8% of Flr to atmospheric concentrations in the tunnel environment. Road dust resuspension contributed mainly to TSP (total suspended particulate matter) concentrations of BaA (29.1%), Py (28.9%), BbF (21.0%), and BaP (21.0%). © 2025 Elsevier B.V., All rights reserved
Evaluation of Scots Pine (Pinus sylvestris L.) High Mountain Afforestation: The Case of the Galyan
No full textBu çalışmada, “Galyan Ağaçlandırma Projesi” kapsamında aktüel orman sınırının yüksek kesimlerinde dikimi gerçekleştirilen sarıçam (Pinus sylvestris L.) fidanlarının 10 yıllık gelişimlerine göre ağaçlandırma başarısının ortaya konması amaçlanmıştır. 2007 yılında dikimi gerçekleştirilen sarıçam ağaçlandırma alanından üç farklı bakı (kuzey, kuzeydoğu, kuzeybatı) ve iki yükselti (1790-1890 m, 1891-1990 m) olacak şekilde örnek alanlar belirlenmiştir. 2011 yılında her bir örnek alanda fidan boyu, kök boğaz çapı, son sürgündeki dal sayısı, kuzey-güney-doğu-batı yönlerindeki en uzun dalların uzunlukları ve tepe tomurcuk sayıları belirlenmiştir. Ayrıca aynı sahaların 2016 yılında (10 yaşındaki) yerinde yapılan incelemelere dayanılarak büyüme seyri takip edilmiş ve buna göre değerlendirmelerde bulunulmuştur. Çalışmada büyüme performansını değerlendirmek için ANOVA, Duncan testi, t-testi ve korelasyon analizi gibi istatistiksel araçlar kullanılmıştır. Sonuçlar, fidan boylarının 2010 yılında ortalama 59,64 cm ve 2016 yılında 93,85 cm değere sahip olduğunu, düşük rakımlarda ve kuzey bakılarda boy büyümesinin daha yüksek olduğu göstermiştir. Başlangıçtaki büyüme yeterli düzeyde olsa da, don, kar basıncı ve su basması gibi aşırı olumsuz iklim koşulları fidanlarda dallanma ve son sürgün hasarı gibi deformasyonlara yol açmıştır. Bunlara rağmen, çalışma sonuçları, kuzeye bakan bakılar ve daha düşük rakımları tercih etmek gibi dikkatli yer seçiminin büyüme sonuçlarını iyileştirebileceğini göstermiştir. Ayrıca, ekolojik ve ormancılık araştırmalarının pratik ormancılık stratejileriyle bütünleştirilmesinin dağlık bölgelerde sürdürülebilir ağaçlandırma için elzem olduğu sonucuna varılmıştır.This study aims to evaluate the afforestation success based on the 10-year development of Scots pine (Pinus sylvestris L.) seedlings planted at higher elevations within the current forest boundary as part of the "Galyan Afforestation Project." Sample plots were selected from the Scots pine reforestation area, established in 2007, based on three different aspects (north, northeast, northwest) and two elevation ranges (1790–1890 m, 1891–1990 m). In 2011, data were collected from each sample plot, including seedling length, root collar diameter, the number of branches on the latest shoot, the lengths of the longest branches in the north, south, east, and west directions, and the number of terminal buds. Additionally, the growth trends of the same areas were monitored based on on-site inspections conducted in 2016 (when the seedlings were 10 years old), and evaluations were made accordingly. Statistical tools such as ANOVA, Duncan test, t-test, and correlation analysis were employed to evaluate growth performance. The results showed that the average seedling height was 59.64 cm in 2010 and 93.85 cm in 2016, with height growth being more pronounced at lower elevations and on north-facing slopes. While initial growth was adequate, extreme climatic conditions such as frost, snow pressure, and waterlogging led to deformities, including branch and terminal shoot damage. Despite these challenges, the findings highlight that careful site selection—favoring northern aspects and lower elevations—can enhance growth outcomes. Furthermore, integrating ecological and forestry research with practical forestry strategies is essential for sustainable reforestation in mountainous regions
Enhancement and Machine Learning-Based Prediction of Tribological Properties of PC/PBT/GNPs Nanocomposites
No full textTernary polycarbonate-poly(butylene terephthalate)/graphene nanoplatelets (PC-PBT/GNP) nanocomposites were fabricated by melt-compounding. The nanofiller dispersion, microstructural changes, and mechanical and tribological properties of the produced samples were investigated. The friction and wear performance of the produced samples were evaluated with a pin-on-disc test rig under 5 and 10 N loads against an AISI 52100 steel ball to evaluate the effect of GNP filler fraction on the friction and wear performance of PC-PBT blends subject to polymer-metal contact in automotive and aviation industries. The impact strength, tensile modulus, and flexural modulus of the neat PC-PBT blend were improved by 78, 46, and 38%, respectively, with the optimum nanofiller fraction of 5 wt %. In parallel to the improved mechanical properties, similar to 86 and similar to 90% reduction in specific wear rates were achieved under 5 and 10 N loads, respectively, compared to the neat sample, which is attributable to multiple factors such as increased stiffness contact surface, intrinsic lubricating characteristics of GNPs, a more tribo-layer-oriented wear regime at higher filler fractions, and increased crystallinity via the reduced extent of transesterification. The Least-Squares Boosting (LSBoost) machine learning model provided the highest prediction accuracy with R 2 = 0.9922 via incorporation of contact pressure calculation results into the model as dependent variables.T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu [123M666]; Scientific and Technological Research Council of Turkey (TUBITAK)The author acknowledges the support from the Scientific and Technological Research Council of Turkey (TUBITAK) under grant no: 123M666
Relationships among social support, healthy lifestyle beliefs, physical literacy, and enjoyment of physical activity: a moderated mediation model
No full textObjective This study aims to examine the relationships between social support, physical literacy, and healthy lifestyle beliefs in adolescents and to investigate the moderating effect of enjoyment of physical activities on these relationships.Method The study was conducted with the participation of 1,349 adolescents. The ages of the participants ranged between 10 and 14 years, and 49.6% were male (n = 669) and 50.4% were female (n = 680). Data were collected using the Healthy Lifestyle Belief Scale for Adolescents to measure adolescents' healthy lifestyle beliefs, the Perceived Physical Literacy Scale for Adolescents (PPLSA) to determine their physical literacy levels, the Social Support Scale in Physical Activities to assess the perception of social support, and the Enjoyment of Physical Activity Scale to measure the level of enjoyment of physical activities. The study tested the moderated mediation model for its association among the variables.Results The model developed in this study found social support in PA predicted health lifestyle beliefs, positively, and significantly. Social support and perceptions of a healthy lifestyle are moderated by physical literacy, research shows. A further analysis also found that the relationship between physical literacy and social support is moderated by enjoyment of physical activities. However, the association between social support and healthy lifestyle beliefs and between physical literacy and healthy lifestyle beliefs were not appreciably influenced by enjoyment in physical activity. The findings indicated that social support has a positive and significant effect on physical literacy and attitudes toward healthy lifestyle. Physical literacy was identified as a central contributor to improving adolescents' health habits by mediating the relationship between social support and conceptions of healthy living. However, the enjoyment of fitness did not matter in some situations, the study found. These results further illustrate the importance of promoting social support and physical literacy instruction to promote a wellness lifestyle adoption by adolescents. The possible long-term effects of feeling good about exercising in various settings, and for health-related habits, should receive more scrutiny.Dicle University Scientific Research Projects (DBAP) Coordinatorship [BESYO.25.006]This work was supported by the Dicle University Scientific Research Projects (DUEBAP) Coordinatorship (Project No: BESYO.25.006). The authors would like to express their sincere gratitude to Dicle University for their valuable support. The author(s) declare that financial support was received for the research and/or publication of this article. This work has been supported by Dicle University Scientific Research Projects (DUEBAP) Coordinatorship. Project number: BESYO.25.006
Menstruation myths scale: A scale development study
No full textObjective The aim of this study was to develop a scale of menstruation myths.Methods The current research was conducted using a methodologic approach with a sample of 330 women who met the inclusion criteria. The scope, structural validity, and internal consistency of the scale were tested.Results As a result of the analyses, it was determined that the scale consisted of 18 items and three factors that explain approximately 57% of the total variance. The Cronbach alpha value of the scale was 0.86 in the first factor, 0.82 in the second factor, 0.83 in the third factor, and 0.91 in total.Conclusion The Menstruation Myths Scale was found to be a valid and reliable measuring tool for reproductive-aged women in Turkish society. It is recommended that the scale be tested with women of different ages, populations, and countries. Additionally, it is believed that the scale can be used to determine myths about menstruation among men
Evaluation of 6th Grade Students' Mathematical Communication Levels within the Framework of Realistic Mathematics Education Approach
No full textThe purpose of this study is to investigate the levels of mathematical communication demonstrated by sixth-grade students in the context of instructional activities grounded in the principles of Realistic Mathematics Education. There are several skills that mathematics education aims to develop in students. Mathematical communication skill is one of these skills. Among the aims of realistic mathematics education is to encourage students to actively participate in the learning process and to make sense of mathematical knowledge in real-life situations. In this study, the case study method, one of the qualitative research methods, was used. The study was carried out during the 2022–2023 academic year at a public middle school located in the Southeastern Anatolia Region, involving 12 students who were selected through convenience sampling. Data were collected through realistic mathematics education problems, interviews, audio recordings, and observations and were subjected to descriptive analysis and content analysis in line with the problems of the study. In individual applications, students' mathematical communication levels were found to be below zero, inadequate, and partially adequate, while in group work, mathematical communication levels were found to be partially adequate, adequate, and constructive. As a result of the study, it was seen that students' mathematical communication levels were at lower levels in realistic mathematics education problems in which they worked individually, while students' mathematical communication levels were at higher levels in group work. In individual tasks, students' levels of mathematical communication were observed to range from below zero to partially adequate, whereas in collaborative group activities, their communication levels ranged from partially adequate to constructive. The findings indicate that students demonstrated lower levels of mathematical communication when engaging with Realistic Mathematics Education (RME) tasks individually, while their communication skills improved notably during group-based problem-solving processes. Based on these results, suggestions were made to increase mathematical communication levels
Environmental impacts of the Filyos Valley Project: Public opinions
No full textFilyos Vadisi Projesi (FVP), Zonguldak'ta hayata geçirilmiş büyük bir sanayi ve liman projesidir. Proje, ekonomik kalkınmayı hızlandırmayı, istihdam yaratmayı ve Türkiye'nin dış ticaretini artırmayı hedeflemektedir. Filyos Limanı, Endüstri Bölgesi ve Serbest Bölgesi gibi bileşenlerden oluşan proje, bölgede ekonomik büyümeyi ve refahı artırmayı amaçlamaktadır. FVP, Sultan Abdülhamid (1876-1909) döneminde temelleri atılan, Türkiye'nin ekonomik ve stratejik hedefleri doğrultusunda önem taşıyan bir projedir. Proje kapsamında Filyos Limanı kurulmuş olup sanayi tesisleri ise kurulma aşamasındadır. Filyos, Karadeniz'de 2021 yılında keşfedilen doğal gaz rezervlerinin işlenmesi ve dağıtımı için önemli bir merkez haline gelmiştir. 2012'de Bakanlar Kurulu kararı ile hayata geçirilen FVP, 2 bin hektarlık alandakurulmuş olup, bu alanın 400 hektarı sanayi tesislerine ayrılmıştır. Filyos Limanı, yıllık 25 milyon ton kargo kapasitesine sahiptir. 2021'deki doğal gaz keşfiyle limanın önemi daha da artmıştır. 4737 sayılı Endüstri Bölgesi Kanunuyla (2002) kamulaştırma yapılarak kamu yararına projeler için arazi tahsisi yapılmaktadır. Filyos Endüstri Bölgesi (344 hektar alan) 4737 sayılı Endüstri Bölgeleri Kanunu'na (2002) göre kurulmuş ve yönetilmektedir. Bu kanun, Türkiye'de endüstri bölgelerinin kurulması, yönetimi ve işletilmesi için yasal bir çerçeve sunmaktadır. Kanunu'nun olumlu etkilerinin yanı sıra, bazı olumsuz etkileri de bulunmaktadır. Endüstri bölgelerinin kurulması ve işletilmesi, çevresel kirlilik riski taşımaktadır. Bu risk, projenin yerel halk nezdinde görüşlerinin incelenmesinin temel nedenini oluşturmuştur. Endüstri bölgesi henüz tam anlamıyla faaliyete geçmemiş ve öngörülen yatırımlar henüz gerçekleşmemiştir. Filyos Limanı ve Endüstri Bölgesi kuruluş ve işletme aşamalarında çevresel riskleri içerisinde barındırmaktadır. Atık yönetimi ve emisyon kontrolü konularında yeterli önlemler alınmadığında, hava, su ve toprak kirliliği gibi sorunlar ortaya çıkabilir. Endüstri bölgelerinin yer seçimi, doğal yaşam alanlarının tahrip edilmesine ve biyolojik çeşitliliğin azalmasına neden olabilir. Endüstri bölgelerinin yoğunlaştığı bölgelerde, aşırı nüfus artışı ve kentleşme sorunları yaşanabilir. Bu durum, altyapı yetersizlikleri, konut sıkıntısı ve sosyal hizmetlerin yetersizliği gibi sorunlara yol açabilir. Bu olumsuz etkilerin en aza indirilmesi için, endüstri bölgelerinin planlanması, kurulması ve işletilmesi süreçlerinde çevresel etki değerlendirmelerinin yapılması, sürdürülebilir kalkınma ilkelerinin benimsenmesi ve etkin denetim mekanizmalarının oluşturulması önemlidir. 4737 sayılı Endüstri Bölgeleri Kanunu (2002), endüstri bölgelerinin planlanması, kurulması ve işletilmesi süreçlerinde çevresel etki değerlendirmelerinin yapılmasını öngörmüştür. Projenin yerel halk nezdindeki görüşlerinin incelenmesi, çevresel risklerin değerlendirilmesinde önemli bir rol oynar. Halkın katılımı, projenin şeffaflığı ve kabul edilebilirliği açısından kritik öneme sahiptir. Projenin çevresel etkilerinin kapsamlı bir şekilde değerlendirilmesi olası olumsuz etkilerin önlenmesi için gereklidir. Bu çalışma, Filyos Vadisi Projesi'nin çevresel etkisini yerel halkın görüşleri üzerinden anket yöntemiyle değerlendirmektedir. Proje alanına yakın yerleşim bölgelerinde yaşayan 412 katılımcıya anket yapılmıştır. Anket soruları, hava ve su kalitesi, ormansızlaşma, toprak verimliliği ve gürültü kirliliği gibi projenin potansiyel çevresel etkilerine dair görüşleri ölçmek üzere tasarlanmıştır. Bulgular projenin çevreye etkisi konusunda yerel halkın endişeli olduğunu ortaya koymuştur. Veriler, SPSS programında istatistiksel analiz yöntemleriyle değerlendirilmiştir. Araştırma sonuçları, katılımcıların özellikle ormansızlaşma ve su kirliliği konularında endişe duyduklarını göstermektedir. Katılımcıların %68'i, projenin su kaynaklarını olumsuz etkilediğini düşünmektedir. Bu bulgular, çevresel etki değerlendirme süreçlerinin daha katılımcı ve şeffaf bir şekilde yürütülmesinin gerekliliğini ortaya çıkarmıştır. Bu çalışma, benzer kalkınma projelerinde yerel halkın görüşlerinin dikkate alınmasının önemini göstermesi açısından gelecekteki araştırmalar için bir temel oluşturmaktadır.The Filyos Valley Project (FVP) is a major industrial and port project in Zonguldak. The project aims to accelerate economic development, create employment and increase Turkey's foreign trade. The project, which consists of components such as Filyos Port, Industrial Zone and Free Zone, aims to increase economic growth and prosperity in the region. The FVP is an important project in line with Turkey's economic and strategic objectives, the foundations of which were laid during the reign of Sultan Abdülhamid (1876-1909). Within the scope of the project, Filyos Port has been established and industrial facilities are in the process of establishment. Filyos has become an important centre for the processing and distribution of natural gas reserves discovered in the Black Sea in 2021. FVP, which was implemented with the decision of the Council of Ministers in 2012, was established on an area of 2 thousand hectares, 400 hectares of which is reserved for industrial facilities. Filyos Port has an annual cargo capacity of 25 million tonnes. With the discovery of natural gas in 2021, the importance of the port has increased even more. With the Industrial Zone Law No. 4737 (2002), land is allocated for projects in the public interest through expropriation. Filyos Industrial Zone (344 hectares) is established and managed according to the Industrial Zones Law No. 4737 (2002). This law provides a legal framework for the establishment, management and operation of industrial zones in Turkey. In addition to the positive effects of the Law, there are also some negative effects. The establishment and operation of industrial zones carries the risk of environmental pollution. This risk was the main reason for analysing the opinions of the local community on the project. The industrial zone is not yet fully operational and the foreseen investments have not yet been realised. The Filyos Port and Industrial Zone involves environmental risks during the establishment and operation phases. When adequate measures are not taken in waste management and emission control, problems such as air, water and soil pollution may arise. Site selection of industrial zones may cause destruction of natural habitats and decrease in biodiversity. Overpopulation and urbanisation problems may occur in areas where industrial zones are concentrated. This situation may lead to problems such as infrastructure inadequacies, housing shortage and inadequacy of social services. In order to minimise these negative impacts, it is important to conduct environmental impact assessments, adopt sustainable development principles and establish effective control mechanisms in the planning, establishment and operation of industrial zones. The Filyos Port and Industrial Zone involves environmental risks during the establishment and operation phases. When adequate measures are not taken in waste management and emission control, problems such as air, water and soil pollution may arise. Site selection of industrial zones may cause destruction of natural habitats and decrease in biodiversity. Overpopulation and urbanisation problems may occur in areas where industrial zones are concentrated. This situation may lead to problems such as infrastructure inadequacies, housing shortage and inadequacy of social services. In order to minimise these negative impacts, it is important to conduct environmental impact assessments, adopt sustainable development principles and establish effective control mechanisms during the planning, establishment and operation of industrial zones. Law No. 4737 on Industrial Zones (2002) stipulates that environmental impact assessments should be carried out during the planning, establishment and operation of industrial zones. Analysing the views of the local community plays an important role in the assessment of environmental risks. Public participation is critical to the transparency and acceptability of the project. A comprehensive assessment of the environmental impacts of the Project is necessary to prevent potential negative impacts. This study evaluates the environmental impact of the Filyos Valley Project through the opinions of local people by using a survey method. A total of 412 respondents living in settlements close to the project area were surveyed. The survey questions were designed to measure opinions on the potential environmental impacts of the project such as air and water quality, deforestation, soil fertility and noise pollution. The findings revealed that local people were concerned about the environmental impact of the Project. The data were analysed using statistical analysis methods in SPSS software. The results show that respondents were particularly concerned about deforestation and water pollution. 68% of the respondents think that the project has a negative impact on water resources. These findings reveal the necessity of conducting environmental impact assessment processes in a more participatory and transparent manner. This study provides a basis for future research as it demonstrates the importance of considering the views of local people in similar development projects
DESIGN, DEVELOPMENT AND HYBRID IMPEDANCE CONTROL OF AN ANKLE REHABILITATION ROBOT
No full textIn this study, a hybrid impedance control-based portable ankle rehabilitation robot that can perform therapeutic exercises for the ankle has been developed. This 1-DOF robot can perform plantar flexion and dorsiflexion movements for the ankle. The capacity of the robotic system to perform therapeutic exercises was tested with subjects. Isotonic and resistive exercises were tested with 10 healthy subjects and stretching exercise was tested with a patient. The results showed that the hybrid impedance controlled robotic system can successfully perform passive stretching, active isotonic and active resistive exercises by providing a safe human-robot interaction. Especially when a sudden resistance increase occurs in the joint, the hybrid impedance controller acts like a physiotherapist and performs the movement without damaging the joint.Yildiz Technical University Office of Scientific Research Project Coordination [FCD-2020-3900]This research is supported by Yildiz Technical University Office of Scientific Research Project Coordination under the grant number FCD-2020-3900