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The Effects of Machine-Based and Manual Hand Massage on Pain, Anxiety, and Gastrointestinal Function Following Laparoscopic Cholecystectomy
No full textBackground: Inadequate management of pain, anxiety, and gastrointestinal function after laparoscopic cholecystectomy can lead to an increase in the incidence of nausea and vomiting, disruption of gastric functions, delayed postoperative recovery, prolonged hospital stay, increased risk of mortality, opioid use, and unwanted side effects. To evaluate the impact of manual and machine-based hand massage following laparoscopic cholecystectomy on pain, anxiety, and gastrointestinal function. Methods: This randomized controlled trial study was conducted with 171 patients. Patients were divided into 2 intervention (manual hand massage and machine-based hand massage) groups (n=57), and a control group (n=57). Data were collected at 0, 4, and 8 hours postoperatively using the survey form, Numerical Rating Scale, State-Trait Anxiety Inventory, and Gastrointestinal Function Monitoring Form. Results: The severity of pain in the manual hand massage group decreased statistically significantly after massage ( P <0.05). Anxiety levels in the intervention groups were lower at all time intervals postoperatively ( P <0.001). The severity of nausea in the massage groups was lower at 8 hours ( P <0.05). The number of bowel sounds at 8 hours in the massage groups showed a greater increase ( P <0.05). Conclusion: Both manual and machine-based hand massage positively affected pain, anxiety, nausea intensity, and bowel sounds following laparoscopic cholecystectomy. Manual hand massage was more effective than machine-based hand massage in reducing pain intensity and increasing bowel sounds.Bartin niversitesihttp://dx.doi.org/10.13039/501100007111The authors thank the hospital managers, nurses, and patients who contributed to the study
Analysis of Work Accidents Caused in the Furniture Industry in Türkiye Between 2013 and 2023
No full textMobilya sektörü ülke ekonomisine verdiği katkı ve istihdam ettiği çalışan sayısı ile ülkemizde önemli sektörlerden biridir. Mobilya imalat süreçlerinde çok çeşitli makine ve ekipmanların bulunması, boya ve kimyasalların kullanılması tehlikeli durumların ortaya çıkmasına neden olmaktadır. Bu nedenlerden dolayı çalışmamızda, 6331 sayılı İş Sağlığı ve Güvenliği Kanunu'nun yürürlüğe girdiği 2013 yılından itibaren mobilya sektöründe yaşanan iş kazalarına ait veriler analiz edilmiştir. Mobilya imalatında yer alan alt sektörlerden, mobilyaların boyanması, verniklenmesi, cilalanması vb. hariç, “tehlikeli” sınıfta yer almaktadır. 2023 yılı verilerine göre mobilya üretiminin %33,8'i, 1 ile 9 çalışanı bulunan mikro ölçekli işyerlerinde gerçekleştiği görülmüştür. Mobilya sektöründe ortalama yılda 6.502 iş kazası meydana gelmektedir. Kaza sıklık hızı 14,50 ile Türkiye ortalamasının üzerindedir. Mobilya sektöründe çalışılan her 100 saatte ise 0,38 saat kaybedilmektedir. Türkiye'de ve mobilya imalatında iş kazaları karşılaştırılarak incelenmiştir. Sonuçlar incelendiğinde sektörde 2013 ile 2023 yılları arasında 4.000 ile 10.000 arasında iş kazası yaşanmakta ve her 5 ile 16 çalışan iş kazalarından dolayı hayatını kaybetmektedir. Mobilya sektöründe yaşanan ve ölümcül olmayan iş kazalarının düşürülmesi için, özellikle mikro ve küçük ölçekli işyerlerinde tehlikelerin belirlenmesi ve önlemlerin alınması önem taşımaktadır.The furniture sector is one of the key industries in Turkey, contributing significantly to the national economy and providing employment to a large number of people. However, the use of various machines, equipment, paints, and chemicals in furniture manufacturing processes can create hazardous situations. In this context, our study analyzes data on occupational accidents in the furniture sector since 2013, when the Occupational Health and Safety Law No. 6331 was enacted. Apart from processes such as furniture painting, varnishing, and polishing, which are part of specific sub-sectors in furniture manufacturing, the sector as a whole is classified as "hazardous." According to 2023 data, 33.8% of furniture production occurs in micro-scale workplaces with between 1 and 9 employees. On average, 6,502 occupational accidents take place annually in the furniture sector, with an accident frequency rate of 14.50 above the national average in Turkey. Additionally, 0.38 hours of work are lost for every 100 working hours in this sector. Comparisons reveal similar trends between occupational accidents in Turkey overall and those specific to the furniture manufacturing sector. Between 2013 and 2023, the sector experienced between 4,000 and 10,000 work accidents, with fatalities occurring among every 5 to 16 employees. Given these figures, identifying hazards and implementing preventive measures are crucial, particularly in micro and small-scale enterprises, to reduce the frequency of occupational accidents in the furniture sector
Effects of online and face-to-face in-service trainings on employee motivation and performance: The case of Bartın University
No full textBu çalışmada, üniversitede çalışan akademik ve idari personelin katıldıkları uzaktan ve yüz yüze hizmet içi eğitimlerin, çalışan motivasyonu ve performansı üzerindeki etkililiğinin belirlenmesi amaçlanmıştır. Araştırmada nitel araştırma yöntemlerinden betimsel tarama modeli kullanılmıştır. Araştırmanın çalışma grubunu Bartın Üniversitesi Rektörlüğü'ne bağlı birimler, fakülteler, yüksekokullar ve meslek yüksekokullarında görev yapan ve hizmet içi eğitimi almış olan toplam 120 akademik ve idari personel oluşturmaktadır. Veriler, araştırmacı tarafından hazırlanan yarı yapılandırılmış görüşme formu ile toplanmıştır. Verilerin analizinde, nitel veri analizi tekniklerinden içerik analizi kullanılmıştır. Araştırma sonucunda elde edilen bulgular, uzaktan ve yüz yüze hizmet içi eğitimlerin çalışan motivasyonu ve performansı üzerinde belirgin etkiler yarattığını ortaya koymuştur. Yüz yüze gerçekleştirilen eğitimler, çalışanların sosyal etkileşimlerini güçlendirerek motivasyonu artırırken, birebir geri bildirim imkânı sunarak öğrenme sürecini desteklemektedir. Öte yandan, uzaktan gerçekleştirilen eğitimler, esneklik sağlaması ve coğrafi sınırlamaları ortadan kaldırmasıyla çalışanların eğitimlere daha kolay erişebilmesini mümkün kılmaktadır. Her iki yöntemin de etkili kullanımının, çalışanların iş becerilerini geliştirmekte olduğu ve performanslarını olumlu yönde etkilediği sonucuna varılmıştır. Ayrıca elde edilen sonuçlar kapsamında gelecekteki çalışmalara yönelik çeşitli önerilere yer verilmiştir.This study aimed to determine the effectiveness of distance and face-to-face in-service training attended by academic and administrative staff working at the university on employee motivation and performance. Descriptive scanning model, one of the qualitative research methods, was used in the research. The study group of the research consists of a total of 120 academic and administrative personnel who work in units, faculties, colleges and vocational schools affiliated to Bartın University Rectorate and have received in-service training. Data was collected with a semi-structured interview form prepared by the researcher. Content analysis, one of the qualitative data analysis techniques, was used to analyze the data. The findings obtained as a result of the research revealed that distance and face-to-face in-service training had significant effects on employee motivation and performance. Face-to-face trainings increase motivation by strengthening employees' social interactions and support the learning process by providing one-on-one feedback. On the other hand, distance training provides flexibility and eliminates geographical limitations, making it possible for employees to access training more easily. It was concluded that the effective use of both methods improves employees' job skills and positively affects their performance. In addition, various suggestions for future studies are included within the scope of the results obtained
Synthesis and biological studies of acetophenone-based novel chalcone, semicarbazone, thiosemicarbazone and indolone derivatives: Structure-Activity relationship, molecular docking, molecular dynamics, and kinetic studies
No full textThis study presents the synthesis and evaluation of nine acetophenone derivatives (1-9), with compounds 2, 4, 5, 6, 7, and 9 being novel and synthesized for the first time. These derivatives encompass diverse structural motifs including chalcone, thiosemicarbazone, semicarbazone, and indolone derivatives. The structures of synthesized compound were confirmed by NMR analysis. The synthesized compounds were assessed for their in vitro enzyme inhibition against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-Glycosidase enzymes, as well as their antioxidant capacities using the DPPH radical scavenging assay. With Ki values ranging from 8.96 +/- 0.40 to 44.16 +/- 4.25 nM, these showed effective inhibition of AChE. However, the inhibitory characteristics of all drugs were almost the same. The Ki values of the two most active compounds, (3) and (4), were 8.96 +/- 0.40 and 11.33 +/- 0.58 nM, respectively. Regarding alpha-Glycosidase, they demonstrate that all novel compounds (1-9) have IC50 values between 30.16 and 133.98 mu M, whereas the Ki values vary from 42.71 +/- 5.90 to 128.78 +/- 8.03 mu M. Compound 4 emerged as a notable inhibitor, displaying significant inhibition against all used enzymes. Molecular docking studies revealed its exceptional binding affinities, corroborated by MM-GBSA Delta G binding free energies, and Glide Emodel scores. Compound 7 also exhibited promising inhibitory potential against alpha-Glycosidase. Docking scores for hAChE -12.207, for hBChE -10.140 and for alpha-Glycosidase -10.590 kcal/mol. The 250 ns molecular dynamics simulations confirmed the stability of the ligand-protein complexes, particularly with compound 4. The ligand-protein complexes were found extremely stable according to the MD simulations. Additionally, ADME predictions indicated favorable pharmacokinetic properties and drug-likeness for all compounds, further supporting their potential as orally active agents. Compound 4, in particular, stands out as a multitarget drug candidate, with strong inhibition against key enzymes implicated in neurodegenerative diseases and diabetes, suggesting its therapeutic potential in these conditions.King Saud University [RSP-2024/59]; Baku State University; Bezmialem Vakif University; Bartin University; Azerbaijan Institute of Chemistry of Additives; Ataturk UniversitySaleh Alwasel wishes to express his heartfelt gratitude to King Saud University's Researchers Supporting Project (RSP-2024/59) .This paper was supported by Baku State University, Bezmialem Vakif University, Bartin University, Azerbaijan Institute of Chemistry of Additives, King Saud University and Ataturk University
Social Studies Lesson in Türkiye As A Means of Citizenship Transfer: A Perspective from The Critical Citizenship Education Approach
No full textIn this study, it was aimed to examine and evaluate the Social Studies Curriculum, which was announced by the Board of Education in 2018 and since then has been implemented. The curriculum was examined according to the critical citizenship approach, which is one of the citizenship approaches, taking into account the grade levels. This study was carried out using a case study design which is appropriate to a qualitative research methodology. Document analysis was used in accordance with the research design and objectives. According to some important findings obtained in the study, it has been observed that the program emphasizes the sense of identity as much as possible while neglecting content aimed at allowing individuals to freely express themselves. The program is shaped around a centralized identity understanding focused on culture, state, and society. The skills of active participation are addressed only in the context of maintaining the existing order and solidarity. The importance of democratic social movements and organized struggle, how they are or can be utilized, the inequalities that exist or may exist in society, and how these issues can be resolved; as well as concrete examples and practice-based information on how the dominant discourse is or can be effective in any area of political or social life, are not included. In general, it has been revealed that social studies education in Turkey, which aims to cultivate effective and responsible citizens, is not approached from a critical citizenship perspective and its content does not align with this approach
Eşikteki Misafir: Derrida'nın Konukseverlik Anlayışı Işığında Yunan Mitlerinin İncelenmesi
No full textThe concept of hospitality holds a significant place in Greek mythology. In recent years, numerous studies across various fields of social sciences have examined the socio-cultural dimensions of hospitality. This study analyzes hospitality in Greek myths within the framework of Jacques Derrida's understanding of conditional and unconditional hospitality. The data for the study are based on five main sources addressing Greek myths: Mythology, Classical Greek Mythology, Dictionary of Mythology, Greek Myths, and Theseus and Athenian Festivals in Ancient Greek Mythology. The obtained data were subjected to content analysis, and the findings were presented accordingly. The analyses revealed that the understanding of hospitality in Greek mythology largely overlaps with Derrida's concept of conditional hospitality. In mythological narratives, guests are expected to adhere to certain rules, meet the host's expectations, and usually offer something in return. On the other hand, examples of unconditional hospitality, as defined by Derrida, are quite scarce in Greek myths. This situation supports Derrida's philosophical argument that unconditional hospitality is an idealized attitude that is difficult, if not impossible, to implement in practical life. In conclusion, this study demonstrates that Derrida's philosophy of hospitality offers a new perspective for understanding hospitality practices in Greek mythology and reveals that the themes of hospitality in mythological narratives predominantly have a conditional structure. This examination is significant in showing how a philosophical concept is embodied through mythological narratives and how Derrida's ideas resonate through ancient texts.Konukseverlik kavramı, Yunan mitolojisinde önemli bir yere sahiptir. Son yıllarda, sosyal bilimlerin farklı alanlarındaki birçok çalışmada konukseverlik kavramının sosyo-kültürel boyutları incelenmektedir. Bu çalışma, Yunan mitlerindeki konukseverliği Jacques Derrida'nın koşullu ve koşulsuz konukseverlik anlayışı çerçevesinde incelemiştir. Çalışmanın verileri, Yunan mitlerini ele alan beş ana kaynağa (Mitologya, Klasik Yunan Mitolojisi, Mitoloji Sözlüğü, Yunan Mitleri, Antik Yunan Mitolojisinde Thesus ve Atina Şenlikleri) dayanmaktadır. Elde eden veriler, içerik analizine tabi tutularak bulguların sunumu gerçekleştirilmiştir. Analizler sonucunda, Yunan mitolojisindeki konukseverlik anlayışının büyük ölçüde Derrida'nın koşullu konukseverlik kavramıyla örtüştüğü görülmüştür. Mitolojik anlatılarda, misafirlerin belirli kurallara uyması, ev sahibinin beklentilerini karşılaması ve genellikle bir karşılık sunması beklenmektedir. Öte yandan, Yunan mitlerinde Derrida'nın tanımladığı anlamda koşulsuz konukseverlik örneklerine ise oldukça az rastlanmaktadır. Bu durum, Derrida'nın koşulsuz konukseverliğin idealize edilmiş ve pratik hayatta uygulanması zor, hatta imkânsıza yakın bir tutum olduğu yönündeki felsefi argümanını destekler niteliktedir. Sonuç olarak çalışma, Derrida'nın konukseverlik felsefesinin Yunan mitolojisindeki misafirperverlik pratiklerini anlamak için yeni bir bakış açısı sunduğunu ve mitolojik anlatılardaki konukseverlik temalarının aslında çoğunlukla koşullu bir yapıya sahip olduğunu ortaya koymaktadır. Bu inceleme, felsefi bir kavramın mitolojik anlatılar üzerinden nasıl somutlaştığını ve Derrida'nın düşüncelerinin antik metinler aracılığıyla nasıl yankı bulduğunu göstermesi açısından önem taşımaktadır
Kitap Kritiği: Türkiye Tarihi Atatürk'ten Bugüne (Maurus Reinkowski)
No full textIn this study, Maurus Reinkowski's book titled TURKISH HISTORY: From Atatürk to Today has been criticised. The study has been prepared especially to understand the effects of the political and social changes Turkey has experienced from the end of the 19th century to the beginning of the 21st century from a historical perspective. Maurus Reinkoewski's area dominance in the geographical region that includes Turkey and his studies on Turcology, this book is the result of long research. The author, who feeds readers from all walks of life with his rich bibliography, has evaluated the phases of the Republic from its foundation to the present day, sometimes in support of the administration and administrators and sometimes with a critical attitude. In this study, in which domestic and foreign documents, memoirs, research and studies are used, the author aims to bring the history of Turkey, which covers approximately 150 years, to the reader with an intellectual analysis. Keyword: Turkey, History of Turkey, Republic, Atatürk, Maurus Reinkowski,Bu çalışmada Maurus Reinkowski'nin kaleme aldığı TÜRKİYE TARİHİ Atatürk'ten Bugüne isimli eser kritik edilmiştir. Çalışma özellikle 19. yüzyıl sonundan 21. yüzyıl başına kadar Türkiye'nin yaşadığı siyasi ve toplumsal değişimin etkilerinin tarihsel perspektiften anlaşılması üzerine hazırlanmıştır. Maurus Reinkoewski'nin Türkiye'yi de içine alan coğrafi bölgedeki alan hakimiyeti ve Türkoloji üzerine yapmış olduğu çalışmalarla beslediği bu kitap uzun araştırmaların sonucunda ortaya çıkmış bir eserdir. Zengin kaynakçası ile her kesimden okuyucuyu besleyen yazar Cumhuriyet'in, kuruluşundan günümüze kadar geçirdiği evreleri zaman zaman yönetimi ve yöneticileri destekleyen bazen de eleştirel bir tutumla değerlendirmiştir. Yerli ve yabancı belgeler, anılar, araştırma ve tetkik eserlerin kullanıldığı bu çalışmada yazar yaklaşık 150 yılı kapsayan Türkiye tarihini entelektüel bir analizle okuyucuya buluşturmayı amaçlamıştır. Anahtar Kelimeler: Türkiye, Türkiye Tarihi, Cumhuriyet, Atatürk, Maurus Reinkowski
Effects of Indole-3-Butyric Acid Application on Rooting and Vegetative Development in Hardwood Cuttings of Pterocarya fraxinifolia (Poiret) Spach
No full textEffects of different concentrations of indole-3-butyric acid (IBA) were studied relative to the rooting success, morphological development, and biomass characteristics of hardwood cuttings of Pterocarya fraxinifolia (Poiret) Spach collected from Diizce, Tiirkiye. Using a factorial design involving two cutting thickness classes and six IBA concentrations, the rooting percentage, number of roots per rooted cutting, shoot length, shoot diameter, number of shoots, fresh and dry shoot weight, and fresh and dry root weights were analyzed. The interaction between IBA concentration and cutting thickness played an important role in the vegetative propagation of Pterocatya fraxinifolia cuttings, especially in terms of rooting success, morphological characteristics, and biomass development. In particular, 1000 ppm and 2000 ppm IBA treatments yielded the most balanced and effective results in terms of rooting, shoot and root development, and biomass production. Although the 8000-ppm dose increased shoot biomass, it suppressed root development, indicating a potential phytotoxic effect at high concentrations. Principal component analysis also supported these findings and showed that 1000 ppm and 2000 ppm IBA doses provided homogeneous and healthy development. The results obtained emphasize that the optimal IBA dose should be carefully selected for the sustainable vegetative propagation; especially applications in the range of 1000 to 2000 ppm can provide important contributions to the propagation and conservation of the species.Scientific and Technological Research Council of Turkiye (Tubitak) [119O027]We would like to thank the Scientific and Technological Research Council of Turkiye (Tubitak) for supporting this study within the scope of the 1002 Rapid Support Program (Project no: 119O027)
Measuring teacher scaffolding in game-based learning: Emotional and responsibility scaffolds lead while resources and previous game experience shape practices
No full textPrevious research shows that teacher characteristics, such as gender and teaching experience, and affective factors, including attitudes and beliefs, influence the integration of games into classrooms. However, there is little understanding of how teachers provide scaffolding to support students' learning during gameplay and address diverse learning needs. Thus, this study aimed to 1) develop and validate a Teacher Scaffolding Questionnaire for Game-Based Learning (TSQGBL), 2) identify the types of scaffolds teachers use most frequently, and 3) examine how the perceived availability of school resources and prior use of game-based pedagogies influence teachers' scaffolding practices. A cross-sectional sample of 180 K-12 in-service teachers participated to validate the instrument, assess scaffolding use, and analyze the relationships between variables. A confirmatory factor analysis validated a three-dimensional model of scaffolding, involving cognitive, responsibility, and emotional scaffolds. Teachers reported greater use of responsibility and emotional scaffolds compared to cognitive scaffolds. Path analysis showed that prior use of game-based pedagogies directly increased scaffold use, while the perceived availability of school resources indirectly influenced scaffolding practices. These findings emphasize the need to increase resource availability and teachers' prior pedagogical experience with games to strengthen scaffolding practices during game-based learning. This study contributes to theoretical advancements by providing a validated instrument and uncovering the relationships between teacher scaffolding practices, the availability of school resources, and prior game-based pedagogy experiences, ultimately supporting the effective integration of games in education.Social Sciences and Humanities Research Council (SSHRC) [435-2021-0612]This research received funding from the Social Sciences and Humanities Research Council (SSHRC) under the award number 435-2021-0612
Phenolic Compounds: Investigating Their Anti-Carbonic Anhydrase, Anti-Cholinesterase, Anticancer, Anticholinergic, and Antiepileptic Properties Through Molecular Docking, MM-GBSA, and Dynamics Analyses
No full textPhenolic compounds are a new class of Carbonic Anhydrase inhibitors (CAIs). Despite numerous advancements in treatment approaches, cancer continues to be a growing health problem worldwide. In our study, we tested the effects of 4-hydroxy-3-methoxyacetophenone (1), doxycycline hydrochloride (2), 5,7-dichloro-8-hydroxyquinoline (3), methyl 3,4,5-trihydroxybenzoate (4), 2-hydroxy-4-methylacetophenone (5), 6-hydroxy-4-methylcoumarin (6), and 2,5-dihydroxyacetophenone (7) on Achetylcholynesterase (AChE), Butrycholynesterase (BChE), and Human Carbonic anhydrase I (hCA I) enzymes. The U2OS human osteosarcoma cell line was used to determine the anticancer potential of these phenolic compounds. The effects of the compounds on proliferation and colony formation were analyzed using the Neutral Red Uptake (NRU) assay and the clonogenic assay. The Ki values of arachidonoyl dopamine, 2,4,6-trihydroxybenzaldehyde, and 3,4-dihydroxy-5-methoxybenzoic acid were 203.80, 1170.00, and 910.00 mM, respectively, for hCA I, and 75.25, 354.00, and 1510.00 mM, respectively, for Human Carbonic anhydrase II (hCA II). Additionally, IC50 values from in vivo studies were found to range from 173.25 to 1360.00 mM for CA I and CA II, respectively, using CO2-hydratase activity methods. The NRU assay results revealed that the compounds had a dose-dependent cytotoxic effect on U2OS cells. The IC50 values of the compounds in U2OS osteosarcoma cells were determined to be > 100, 93.7, 81.4, 26.9, > 100, 53.1, and > 100 mu M, respectively. Notably, methyl 3,4,5-trihydroxybenzoate (4), the compound with the lowest IC50 value, significantly suppressed colony formation at 5 and 10 mu M concentrations. These results demonstrated that the phenolic compounds used in in vivo studies could inhibit approximately 30% of the CO2-hydratase activity of the total CA enzyme of rat erythrocytes. Furthermore, the anticancer potential of the tested compounds suggests that these molecules could pave the way for the development of new approaches in cancer treatment. The activities of the seven molecules studied were compared against AChE (PDB ID: 4M0E), BChE (PDB ID: 5NN0), hCA I (PDB ID: 2CAB), and E3 ubiquitin-protein ligase (PDB ID: 4HG7) proteins. The binding free energy of the molecule with the highest docking score is computed using MM/GBSA techniques. Finally, molecular dynamics simulations were performed between 6-hydroxy-4-methylcoumarin and the 4M0E protein over a 0-200 ns interval.Sivas Cumhuriyet niversitesi [RGD-020]; Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP)This work was supported by the Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP) under the project number RGD-020