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L’adultère à bas bruit, ou le procès du silence chez Mme de Lafayette
No full textInternational audienc
Pascal et Claudel : la conversion, pierre d’achoppement ?
No full textBlaise Pascal : la conversion de l'homme : actes du colloque de l'Institut catholique de Paris des 22 et 23 novembre 2023, à l'occasion du quatrième centenaire de la naissance de Pascal / textes réunis par David Gilbert et Jean de Saint-ChéronInternational audienc
"Résister professionnellement au sentiment de déclassement grâce aux pédagogies Montessori"
No full textInternational audienc
Real-world multicentre study of cefiderocol treatment of immunocompromised patients with infections caused by multidrug-resistant Gram-negative bacteria: CEFI-ID.
No full textInternational audienceThe increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria. This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023). Clinical and microbiological outcomes, including infection cure, relapse, as well as mortality, and resistance acquisition, were assessed at days 28 and 90. Antibiotic prescription compliance with current guidelines was investigated. At day 28, clinical success was achieved in 53.3% of cases, and overall mortality was 37.7%, consistent with other studies (33-37%). Infection-related mortality accounted for 25.4%. Relapse occurred in 17.5% of patients by day 28, rising by an additional 9.8% among survivors by day 90. Resistance acquisition was observed in two cases at day 28 (Pseudomonas aeruginosa and Stenotrophomonas maltophilia) and in three additional cases by day 90. FDC was used as monotherapy in 49.1% of cases, with a median treatment duration of 10 days. Nearly 25% of strains collected in FDC-treated patients were susceptible to best-practice alternatives. These findings highlight FDC's utility in difficult-to-treat infections, particularly S. maltophilia, but the high relapse rate and resistance acquisition underscore the need for careful monitoring, adherence to guidelines, and reconsideration of empirical use to prevent resistance and improve outcomes in fragile populations
A systematic approach to parameterization of disaccharides for the Martini 3 coarse-grained force-field
No full textSugars are ubiquitous in biology; they occur in all kingdoms of life. Despite their prevalence they have often been somewhat neglected in studies of structure-dynamics-function relationships of macromolecules to which they are attached, with the exception of nucleic acids. This is largely due to inherent difficulties of studying not only conformational dynamics of sugars using experimental methods, but indeed also resolving their static structures. Molecular Dynamics (MD) simulations offer a route to prediction of conformational ensembles and the time-dependent behaviour of sugars and glycosylated macromolecules. However, at the all-atom level of detail, MD simulations are often too computationally demanding to allow a systematic investigation of molecular interactions in systems of interest. To overcome this, large scale simulations of complex biological systems have profited from advancements in coarse-grained (CG) simulations. Perhaps the most widely used CG force field for biomolecular simulations is Martini. Here we present a parameter set for glucose and mannose-based disaccharides for Martini3. The generation of the CG parameters from atomistic trajectories is automated as fully as possible and where not possible, we provide details of the protocol used for manual intervention
Antigua presencia de Theodoxus sp. (Gastropoda: Neritidae) en el Tajo español: una evidencia arqueológica para la Edad Media
No full textInternational audienceThis study analyzes the discovery of Theodoxus sp. shells at the medieval archaeological site of Albalat (Extremadura, Spain), associated with direct (14C) and indirect dating (ceramic typologies, coins) to the 11th-12th centuries. The archaeological context suggest that the shells were accidentally incorporated into the site, likely caught in the nets used to exploit the river’s fishing resources, which have also been documented at Albalat. Therefore, it demonstrates the ancient presence of populations of Theodoxus sp. in the Spanish section of the Tagus River, where they now seem to have become extinct. This extinction could be related to the implementation and development of wastewater evacuation systems in Madrid and its surroundings cities since the 1850s. This discharges still constitutes the main source of pollution in the Tagus River.En este estudio se analiza el hallazgo de conchas de Theodoxus sp. en el yacimiento medieval de Albalat (Extremadura, España), asociados con dataciones directas ( 14 C) e indirectas (tipologías cerámicas, monedas) para los siglos XI-XII. El contexto arqueológico indica que las conchas se habrían incorporado al yacimiento de forma accidental, aportadas en las redes usadas para explotar los recursos pesqueros del río, que también se han documentado en Albalat. Por tanto, demuestra la antigua presencia de poblaciones de Theodoxus sp. en el tramo español del río Tajo, donde actualmente parecen haberse extinguido. Esta extinción podría estar relacionada con la implantación y desarrollo de las estructuras de evacuación de aguas residuales en Madrid y su entorno a partir de la década de 1850. Estas aguas residuales aún constituyen la principal fuente de contaminación en el río Tajo
