International Journal of Advances in Pharmaceutical Analysis
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SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF FAMOTIDINE IN DRUG FORMULATIONS.
Get PDFThis paper describes two sensitive and simple spectrophotometric methods for determination of famotidine in pharmaceutical preparations. The first method is based on the hydrolisis of famotidine with sodium hydroxide assisted with microwave radiation, whereby the sulfide ion is produced. The sulfide was allowed to react with N,N diethyl p phenylendiamine oxalate and Fe(III), and the blue color produced was measured at 671 nm. Beer law was fulfilled in the concentration range 0.6 52.
A VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF ABACAVIR IN BULK AND TABLET DOSAGE FORMS
Get PDFA rapid, precise, accurate, specific and simple RP-HPLC method was developed for the estimation of Abacavir in bulk and in tablet dosage form. A High performance liquid chromatograph 10AT SHIMADZU- SPD10A, using Phenomenex - Luna RP-18(2),250X4.6mm, 5 mm column, with a mobile phase compose
Development of Stability Indicating RP-HPLC Method for Determination of Levosulpiride Hydrochloride In Bulk And Pharmaceutical Dosage Form
Get PDFA rapid, specific and sensitive stability indicating reverse phase high performance liquid chromatographic method has been developed and validated for analysis of levosulpiride hydrochloride in both bulk and pharmaceutical dosage form. An isocratic stability indicating reversed-phase liquid chromatographic determination was developed for the quantitative determination of levosulpiride in the pharmaceutical dosage form. A sunfire C-18, 4.5mm column with mobile phase containing methanol-water (10:90, v/v) was used. The flow rate was 1.0 mL min -1 and effluents were monitored at 232 nm. The retention time of Levosulpiride was 5.5 min. Levosulpiride stock solutions were subjected to acid and alkali hydrolysis, chemical oxidation, wet hydrolysis, dry heat degradation and sun light degradation. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time values. Stressed samples were assayed using developed LC method. The proposed method was validated with respect to linearity, accuracy, precision and robustness. The method was successfully applied to the estimation of Levosulpiride in tablet dosage forms. The proposed study describes stability indicating LC method for the estimation of Levosulpiride in bulk and their pharmaceutical dosage form. The method is suitable for the routine analysis of Levosulpiride in tablets
STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF FRUSEMIDE AND AMILORIDE HYDROCHLORIDE IN TABLET DOSAGE FORM
Get PDFThis article focuses on stability indicating RP-HPLC method for simultaneous estimation of Frusemide and Amiloride Hydrochloride as API and in tablet dosage form, validation ofdeveloped method and its application in pharmaceutical companies. Acetonitrile, potassium di hydrogen phosphate and phosphoric acid were used. Chromatographic conditionscomprised of C18 column (250 × 4.6 mm,
DEVELOPMENT AND VALIDATION OF A RP- HPLC METHOD FOR ESTIMATION OF ROSIGLITAZONE IN BULK AND TABLET DOSAGE FORM
Get PDFA simple reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated of rosiglitazone in bulk and tablet dosage form. Chromatographic analysis was performed on a C18 column (250x 4.6 mm,
DETERMINATION OF OPTICAL CONSTANTS AND OPTICAL BAND GAP IN GE40TE60-XSBX THIN FILMS
Get PDFThe optical transmission spectra of thin films of Ge 40 Te 60-x Sb x (x = 0, 2, 4, 6 and 10), prepared by vacuum evaporation technique from their corresponding bulk samples, are recorded over the spectral region of 500 270
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF METFORMIN HYDROCHLORIDE ON LABORATORY SCALE
Get PDFThe purpose of this research is to prepare metformin hydrochloride immediate release tablets by wet granulation technique. In order to obtain the best, optimized product ten different formulations were developed. Different binder, disintegrants and lubricants taken as variables. Weight variation, thickness, hardness, friability, disintegration time, in-vitro release and pharmaceutical assay were studied as response variables. Capping was observed in formulation containing PVP K-30. However, in the remaining formulation containing PVP K-90, no capping was observed. The formulation A7 was selected as optimized formulation. The different physical properties and in-vitro release profile showed best comparable with the reference product. Optimization has proven an effective tool in product development
STABILITY STUDIES ON DICLOFENAC SODIUM CREAM
No full textoai:ojs.pkp.sfu.ca:article/1334Diclofenac is a non-selective COX inhibitor. In US, currently, it is available only in various tablet and solution formulations from commercial manufacturer. In this manuscript, we have investigated the stability of diclofenac sodium in cream preparations involving two proprietary bases at both