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Process for the preparation of safinamide
No full textThe present invention relates to a process for the preparation of spherical agglomerates of safinamide or a pharmaceutically acceptable salt thereof, to the agglomerates thus obtained and to a process for preparing a pharmaceutical composition including said agglomerates
Some fast algorithms multiplying a matrix by its adjoint
No full textInternational audienceWe present a non-commutative algorithm for the multiplication of a 2 × 2 block-matrix by its adjoint, defined by a matrix ring anti-homomorphism. This algorithm uses 5 block products (3 recursive calls and 2 general products)over C or in positive characteristic. The resulting algorithm for arbitrary dimensions is a reduction of multiplication of a matrix by its adjoint to general matrix product, improving by a constant factor previously known reductions. We prove also that there is no algorithm derived from bilinear forms using only four products and the adjoint of one of them. Second we give novel dedicated algorithms for the complex field and the quaternions to alternatively compute the multiplication taking advantage of the structure of the matrix-polynomial arithmetic involved. We then analyze the respective ranges of predominance of the two strategies. Finally we propose schedules with low memory footprint that support a fast and memory efficient practical implementation over a prime field
Dendritic bubble growth during the sub-atmospheric boiling of water in a narrow vertical channel
No full textInternational audienceThe bubbles observed during the boiling of water at subatmospheric pressure (a few mbar) behave in a very atypical way compared to under atmospheric pressure. Moreover, the presence of very close walls significantly affects bubble dynamics and interface disturbances like fingering can be observed during growth. Interface perturbations were reported in a phenomenological analysis. Image processing software was developed to process the obtained high resolution camera recordings. Based on this software, physical quantities characterising the bubble are measured for the purpose of a parametric study of the dentritic growth of the bubbles. It appeared that the bubble interfacial velocity , bubble interface acceleration and nucleation immersion depth, related to inertia and hydrostatic pressure, have a significant influence on the fingering occurrence
Permafrost modelling with OpenFOAM®: New advancements of the permaFoam solver
No full textInternational audienc
Synthesis, photophysics, and theoretical calculations of styryl-based fluorophores harboring substituted benzothiazole acceptors
No full textInternational audienceThis study describes the synthesis, photophysical characterization, and TD-DFT calculation of a series of benzothiazole-based styryl fluorophores (F1-F5) harboring a D-π-A structure. The compounds were obtained through a simple and efficient synthetic route using low-cost starting materials. The investigation and analysis of their photophysical properties enable the assessment of the effect of four substituted benzothiazole moieties (A) and two types of π-conjugated frameworks (phenyl vs thienyl) in solution and in solid state. The fluorophores disclose absorption in the ultraviolet-blue region with a moderate solvatochromic effect and a single emission band located at the blue-green spectral range. In the solid state, the fluorophores showed emission in the green-orange regions with a relatively large Stokes shift. The systematic UV-Vis solvatochromism study and theoretical predictions using the CPCM model reveals the increment in the dipole moment of the systems in an excited state with the solvent dielectric constant. These compounds showed high fluorescence quantum yield in solution and in solid-state and could be further exploited for solid-state lighting devices, or embedded in the design of biological dyes
Blind broad-band (0-10 Hz) numerical prediction of the 3-D near field seismic response of a Mw6.0 extended fault scenario: application to the nuclear site of Cadarache (France)
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Asphaltenes, subfractions A1 and A2 aggregation and adsorption onto RH-SiO 2 nanoparticles: solvent effect on the aggregate size
No full textInternational audienceThe aggregation and adsorption of asphaltenes in dilute solutions has been extensively studied and is now well established. At low concentrations, asphaltenes are mainly found in the form of aggregates of approximately 3 nm in size. One strategy to simplify the study of these systems has been to fractionate the asphaltenes into subfractions called A1 and A2. The nature of these subfraction aggregates, their behavior with the concentration and their interaction with other aggregates and surfaces remain under debate. This work presents experimental results on the aggregation and adsorption of asphaltenes and their subfractions A1 and A2 onto SiO2 nanoparticles from rice husks (RH-SiO2), and the evidence allows us to infer that the aggregates are in equilibrium in solution over a wide range of concentrations. The size distribution for each subfraction does not change with dilution but is sensitive to solvent media. Subfraction A1 has a very similar behavior to asphaltenes, while subfraction A2 tends to form larger aggregates. Larger aggregates more likely adsorb on surfaces than small aggregates. According to the results, the interaction of the aggregates in different solvents can be studied as a phase change phenomenon, where the aggregate can be considered a partially immiscible phase in a solvent. The theoretical principles are described, and a hypothesis is elaborated in these terms