Hal-Diderot
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Les personnes en situation de handicap : devenir et être fonctionnaires
No full textInternational audienc
Droits de la personnalité
No full textInternational audience(Janvier 2022 - Décembre 2022) - Conseil d'État, 7 octobre 2022, no 443826, Cour de cassation (com.), 26 janvier 2022, no 19-10.949, Cour de cassation (com.), 7 septembre 2022, no 21-12.602, Cour de cassation (soc.), 19 janvier 2022, no 20-12.420 et Cour de cassation (1re civ.), 11 mai 2022, no 20-23.39
Pour une intelligence artificielle adaptée aux valeurs sociales et communautaires : l'exemple de l'Ubuntu au Sénégal
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"Autorisation de transfert du contrat d'un salarié protégé : la fraude aux dispositions de l'article L. 1224-1 hors champ du contrôle administratif"
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La revendication de la qualité d'associé : l'article 1832-2 du code civil n'a pas livré tous ses mystères
No full textInternational audienceNote sous Cour de cassation (com.), 21 septembre 2022, no 19-26.203 (FS+B
La grande distribution au Maroc face aux acheteurs illettrés: Enjeux et implications pour les acteurs
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Calcium Handling in Inherited Cardiac Diseases: A Focus on Catecholaminergic Polymorphic Ventricular Tachycardia and Hypertrophic Cardiomyopathy
No full textInternational audienceCalcium (Ca 2+) is the major mediator of cardiac contractile function. It plays a key role in regulating excitation-contraction coupling and modulating the systolic and diastolic phases. Defective handling of intracellular Ca 2+ can cause different types of cardiac dysfunction. Thus, the remodeling of Ca 2+ handling has been proposed to be a part of the pathological mechanism leading to electrical and structural heart diseases. Indeed, to ensure appropriate electrical cardiac conduction and contraction, Ca 2+ levels are regulated by several Ca 2+-related proteins. This review focuses on the genetic etiology of cardiac diseases related to calcium mishandling. We will approach the subject by focalizing on two clinical entities: catecholaminergic polymorphic ventricular tachycardia (CPVT) as a cardiac channelopathy and hypertrophic cardiomyopathy (HCM) as a primary cardiomyopathy. Further, this review will illustrate the fact that despite the genetic and allelic heterogeneity of cardiac defects, calcium-handling perturbations are the common pathophysiological mechanism. The newly identified calcium-related genes and the genetic overlap between the associated heart diseases are also discussed in this review
Intravoxel incoherent motion and diffusion kurtosis imaging at 3T MRI: Application to ischemic stroke
No full textInternational audienceBACKGROUND AND PURPOSE: The DKI-IVIM model that incorporates DKI (diffusional kurtosis imaging) into the IVIM (Intravoxel Incoherent Motion) concept was investigated to assess its utility for both enhanced diffusion characterization and perfusion measurements in ischemic stroke at 3 T. METHODS: Fifteen stroke patients (71 ± 11 years old) were enrolled and DKI-IVIM analysis was performed using 9 b-values from 0 to 1500 s/mm(2) chosen with the Cramer-Rao-Lower-Bound optimization approach. Pseudo-diffusion coefficient D*, perfusion fraction f, blood flow-related parameter fD*, the diffusion coefficient D and an additional parameter, the kurtosis, K were determined in the ischemic lesion and controlateral normal tissue based on a region of interest approach. The apparent diffusion coefficient (ADC) and arterial spin labelling (ASL) cerebral blood flow (CBF) parameters were also assessed and parametric maps were obtained for all parameters. RESULTS: Significant differences were observed for all diffusion parameters with a significant decrease for D (p < 0.0001), ADC (p < 0.0001), and a significant increase for K (p < 0.0001) in the ischemic lesions of all patients. f decreased significantly in these regions (p = 0.0002). The fD* increase was not significant (p = 0.56). The same significant differences were found with a motion correction except for fD* (p = 0.47). CBF significantly decreased in the lesions. ADC was significantly positively correlated with D (p < 0.0001) and negatively with K (p = 0.0002); K was also negatively significantly correlated with D (p = 0.01). CONCLUSIONS: DKI-IVIM model enables for simultaneous cerebral perfusion and enhanced diffusion characterization in an acceptable clinically acquisition time for the ischemic stroke diagnosis with the additional kurtosis factor estimation, that may better reflect the microstructure heterogeneity
Methyl methacrylate thermal decomposition: modeling and laser spectroscopy of species time-histories behind reflected shock waves
No full textInternational audienceThe thermal decomposition of methylmethacrylate (MMA) was studied through species time-history measurements of formaldehyde (CH 2 O), carbon monoxide (CO), and carbon dioxide (CO 2) behind reflected shock waves over a temperature range of 1200-1600 K near 1 atm. Tunable laser absorption spectroscopy was employed to spectrally and temporally-resolve a cluster of rovibrational lines in the Q-branches of the v 1 fundamental band and the v 2 +v 4 combination band of CH 2 O near 3.60 µm, three rovibrational transitions in the P-branch of the fundamental band of CO near 4.98 µm, and a transition in the R-branch of the (01 0 0→01 0 1) v 3 band of CO 2 near 4.19 µm. Spectral fitting procedures are subsequently used to infer CO, CO 2 , and CH 2 O mole fraction during the pyrolysis of shock-heated mixtures of MMA in argon. These data provided valuable experimental constraints on MMA pyrolysis chemical kinetic models. Sensitivity analysis of a detailed chemical model for MMA decomposition identified specific reactions likely to account for differences observed between the species measurements and simulations of the test conditions. Modified reaction rate parameters for select MM