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Structural and functional characteristics of β-lactoglobulin/Cphycocyanin/starch composite gels induced by pressure
No full textInternational audienceHigh-pressure processing (HPP) has emerged as a key sustainable green alternative for food treatment, effectively preserving food's sensory and nutritional properties. This study investigated the potential of HPP to develop β-lactoglobulin (BLG) gels in the presence of starch and the bioactive blue protein C-phycocyanin (C-PC). Various compositions of binary (BLG/C-PC and BLG/starch) and ternary (BLG/C-PC/starch) systems were subjected to high-pressure (HP) conditions at 4,500 bar. BLG, C-PC, and starch concentrations were maintained at 180, 10, and 5 g/L. HP-induced hydrogels preserve C-PC colour and partial preservation of secondary and tertiary structures, as evidenced by visible absorption and CD spectroscopy. SAXS data at the high-Q range revealed that C-PC induces the unfolding of BLG within binary system gels. In contrast, the ternary system gel maintained the BLG tertiary structure better. C-PC and starch affected the nano and microstructures of BLG HP-induced gels by increasing the pore size, as demonstrated by SAXS (at low Q-range) and SEM analysis. This increase in pore size further influenced the resulting gels' rheological behaviour and texture profile. C-PC enhanced the protein solubility and antioxidant activity of the HP-induced gels, potentially boosting the bioactive and nutritional value of the developed gels
Cosmological simulations of the same spiral galaxy: satellite properties, the role of baryonic physics and star formation history in shaping dark matter cores/cusps
No full textWe investigate the role of baryonic physics in shaping the population, structure, and internal dynamics of galactic subhalos using the Mochima suite of cosmological zoom-in simulations. A refined method is developed to identify bound subhalo material by isolating the local gravitational potential and applying multi-criteria phase-space selection. This approach enables a robust characterisation of subhalo properties across five baryonic runs with varying prescriptions for star formation, and supernova and protostellar feedback, as well as a dark matter-only baseline. At the population level, we find that host halo concentration, modulated by baryonic feedback, is a key predictor of subhalo survival. Subhalos with more massive stellar components exhibit deeper internal potentials and enhanced resilience to tidal disruption. At the structural level, we identify a broad diversity in inner dark matter profiles, consistent with observations of dwarf galaxies. We show that this diversity correlates with both star formation history and environmental interaction. In particular, galaxies that form most of their stars early tend to retain steep cusps, while those with extended or recent star formation exhibit oscillating inner slopes shaped by bursty feedback and tidal perturbations. These findings suggest that the so-called "diversity problem" may reflect the complex interplay between feedback history and gravitational environment, rather than a breakdown of cold dark matter predictions.</div
Nonlinear Terahertz electroluminescence from Dirac-Landau polaritons
No full textWe report the observation of Dirac-Landau polaritons via THz magnetoreflectivity spectroscopy, demonstrating strong coupling between cyclotron transitions of two-dimensional Dirac fermions in HgTe quantum wells and optical cavity modes. We demonstrate efficient nonlinear electroluminescence, characterized by a strongly out-of-equilibrium polariton distribution dominated by emission from the upper polariton branches. Model calculations, based on the nonlinear dependence of the emission intensity and spectral narrowing with bias voltage, indicate a polariton occupancy per mode close to unity, with a significant contribution from stimulated polariton emission. These findings open promising prospects for the development of Dirac-Landau polariton condensates and low-threshold, tunable terahertz polariton lasers based on cyclotron emission.</div
Temperature and doping level effect on silicon thermal conductivity
No full textInternational audienc
Genome-scale transcriptome augmentation during Arabidopsis thaliana photomorphogenesis
No full textPlant photomorphogenesis is a light-induced developmental switch that combines massive reprogramming of gene expression and a general enhancement in RNA Polymerase II activity. Yet, transcriptome analyses have failed to demonstrate a clear tendency toward gene upregulation. To solve this conundrum, we optimized a spike-in RNA-seq experimental and analysis pipeline and reconciled transcriptome dynamics with epigenomic and cytogenetic observations. We found that light induces a two-fold expansion of the transcriptome during Arabidopsis thaliana cotyledon photomorphogenesis, with 94% of the 9,128 differentially expressed genes being upregulated within the first six hours. Transcriptome augmentation was further detected at a similar strength in spike-free RNA-seq datasets from independent laboratories renormalized using stable genes that mimic the spike-in information. On this new basis, reinterpretation of light-mediated gene regulatory pathways revealed a quasi-exclusive positive effect of HY5 and other key light-induced transcription factors at target genes. This new standpoint unveiled the unilateral impact of light on the transcriptome of Arabidopsis cotyledons at the genome scale and opens new avenues for investigating global genome regulation during plant developmental and environmental responses
Assessing the contact quality of Si p-n diodes through series resistance noise characterization
No full textInternational audienceUsing LFN measurement on Si p-n diodes, series resistances are shown to contribute to noise at large currents values. With adequate modelling, quantitative estimation of the contact quality is obtained, which could be employed as a tool for device reliability and process assessment
Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa
No full textInternational audienceBackground: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting approximately 1% of the global population. Its pathogenesis involves both aberrant keratinization and autoinflammation, but the temporal relationship between these processes remains unclear.Objective: To investigate the role of HF stem cell (HF-SC) fate in the early pathogenesis of HS. Methods: We performed single-cell RNA sequencing of HF cell populations from HS patients and healthy donors. We then analysed HF cell composition isolated from perilesional skin of 49 HS patients and integrated these data with clinical phenotypes to define disease endotypes.Results: Our data revealed two distinct differentiation trajectories of HF stem cells (HF-SCs): one leading to interfollicular epidermis (IFE) basal cells enriched in inflammatory pathways, and another giving rise to outer root sheath (ORS) cells associated with keratinization. In HS lesions, both populations displayed altered inflammatory phenotypes and were closely linked to immune cell infiltration, pointing to a role in disease heterogeneity. By integrating clinical features with HF cell composition from 49 HS patients, we identified three major endotypes: (i) an inflammatory subtype, marked by T cell infiltration and an expansion of IFE basal cells; (ii) a keratinizing subtype, characterized by ORS enrichment and minimal inflammation; and (iii) a mixed subtype, exhibiting features of follicular remodelling, fistula formation and variable immune involvement.Conclusion: These findings provide novel insights into the epithelial-immune interactions that drive HS and support a stratified therapeutic approach tailored to distinct epithelial dysfunctions
Combining Molecular Mechanics and Quantum Chemistry in pDynamo: A 30-Year Journey Dedicated to Hybrid Simulations.
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Using System Code for Scaling Analysis: A NewIntegrated Tool in the CATHARE Code Applied to a SB-LOCA Transient
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Livret des visuels d'interventions - Restitution des résultats du projet ANR SENTINEL
No full textLivret des visuels d'interventions - Webinaire de la restitution des résultats du projet ANR SENTINE