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Sensitivity of the Hyper-Kamiokande experiment to neutrino oscillation parameters using acceleration neutrinos
No full textInternational audienceThis paper describes the analysis to estimate the sensitivity of the Hyper-Kamiokande experiment to long-baseline neutrino oscillation parameters using accelerator (anti)neutrinos. Results are presented for the CPV discovery sensitivity and precision measurements of the oscillation parameters , , and . With the assumed Hyper-Kamiokande running plan, a CPV discovery is possible in less than three years in the case of maximal CPV and known MO.In the absence of external constraints on the MO, considering the MO sensitivity of the Hyper-Kamiokande measurement using atmospheric neutrinos, the time for a CPV discovery could be estimated to be around six years. Using the nominal final exposure of protons on target, corresponding to 10 years, with a ratio of 1:3 in neutrino to antineutrino beam mode, we expect to select approximately 10000 charged current, quasi-elastic-like, muon neutrino events, and a similar number of muon anti-neutrino events. In the electron (anti)neutrino appearance channels, we expect approximately 2000 charged current, quasi-elastic-like electron neutrino events and 800 electron antineutrino events. These larges event samples will allow Hyper-Kamiokande to exclude CP conservation at the significance level for over 60% of the possible true values of
Unbound neutron strength in C and the shell gap
No full textInternational audienceSignificant continuum strength has been observed to be populated in 17C produced in the d(16C,p) reaction at a beam energy of 17.2 MeV/nucleon. The strength appears at greater than ∼2 MeV above the single-neutron decay threshold and has been identified as arising from transfer into the neutron 0d3/2 orbital. Guided by shell model predictions the greater majority of the strength is associated with a 3/2+ state at an excitation energy of 4.40−0.14+0.33 MeV and a much weaker 3/2+ level at 5.60−0.45+1.35 MeV. The corresponding total widths were determined to be 3.45−0.78+1.82 and 1.6−1.4+4.6 MeV, respectively. From the backward angle proton differential cross sections and the branching ratios for neutron decay to the 16C(21+) level, the corresponding spectroscopic factors to the ground state were deduced to be 0.47±10 and <0.09. Shell-model calculations employing the phenomenological SFO-tls interaction as well as Gamow Shell-Model calculations including continuum effects are in reasonable agreement with experiment, although the predicted strength lies at somewhat lower energy. The size of the N=16 shell gap (εν0d3/2−εν1s1/2) was estimated to be 5.08−0.33+0.43 MeV - some 1.3 MeV larger than found in the SFO-tls shell model calculation
PRÉSENTATION - Découverte et bonnes pratiques des données de la recherche dans le cadre de la science ouverte
No full textInternational audienceGeneral presentation on open science, given during a workshop at "Printemps de la donnée", an event organised by Clermont-Auvergne University.Présentation généraliste autour de la science ouverte, réalisée le temps d'un atelier lors du Printemps de la donnée, évènement organisé par l'Université Clermont-Auvergne
Action concertée transverse 2 èmes Journées nationales du Packaging -20-21 mai 2025 -FEMTO-ST -Besançon
No full textNational audienceTravaux de l'ACPAC du PEPR électronique lors des deuxièmes journées nationales du packagin
Comparison of star-allele caller performances on genotyping and sequencing data at different geographic scales
No full textInternational audiencePharmacogenetics is the study of genetic variants responsible for variable response tomedication. These variants can explain alternate drug responses, and understanding their effects thusrepresents a key public health issue. To standardize pharmacogenetics studies, a specific nomenclatureis used: the star-alleles, which associates haplotypes with the activity of a given pharmacogene. Suchhaplotype calling can be influenced by population origin, the complexity of the genomic region inquestion and choice of reference data; many star-allele callers have been developed with little insighton their performance in different scenarios.The objective of this study is to determine the performances of the different tools available.To do this, we used sequencing data from the 1000 Genomes and FranceGenRef projects.To this end, we have benchmarked different pipelines of star-allele annotation. We haveobserved some discrepancies between the output of star-allele annotation pipelines, coming fromdifferences in the reference database used, the method employed and the range of each pipeline interms of gene coverage and variant detection. We have also evaluated the impact of imputation onstar-allele calling, examining its influence on calling accuracy and downstream phenotype predictionto assess the reliability of imputed data. We provide recommendations on which tools to use regardingthe data available, the population observed and the gene studied.This study provides insights into the strengths and limitations of different star-allele callersused for inferring unobserved data. These findings contribute to the assessment of the potentialbenefits of personalized care informed by pharmacogenetic variant information
Assessment of Ni and Mn effect on the irradiation hardening behavior of VVER-1000 model steels exposed to high fluences in the high flux reactor
No full textInternational audienceIn the present work, we aim at providing more data and insight related to the influence of Ni and Mn contents on the degree of irradiation hardening of Light Water Reactor RPV steels. A total of 20 model steels and realistic welds based on VVER-1000 and PWR RPVs compositions were irradiated at high flux and to high fluences in the LYRA-10 experiment, conducted in the High Flux Reactor, Petten. Among them, eight VVER-1000 model steels with 0.1 wt % Cu and systematically varied Mn and Ni contents were submitted to tensile and Vickers hardness testing for evaluation of their degree of hardening, and were characterized in detail, using Atom Probe Tomography, Transmission Electron Microscopy, Small Angle Neutron Scattering and Positron Annihilation Spectroscopy. The mechanical testing results show the clear increase in degree of irradiation hardening with the Mn and Ni contents, in particular for steels containing 1.4 wt % Mn. Microstructural observations show direct correlation between increase in yield strength and the formation of Mn-Ni-Si solute clusters. Calculations done using classic and multiscale models confirm that the solute clusters are the main hardening features present in the irradiated RPV model steels. Furthermore, TEM and PAS results suggest that dislocation loops have a more significant role on the formation of solute clusters than on irradiation hardening of the group of materials investigated
Hybrid interface tracking method of multi-phase flows, for additive manufacturingand welding applications
No full textInternational audienc
Freed from Iron easy release of a stable ketene from the reaction of CO with di-iron bis-μ2-alkylidenes.
No full textInternational audienceIron bis-μ2-alkylidene complexes were shown to perform CO/alkylidene coupling and liberate a stable ketene derivative. The easy release of the ketene formed from CO incorporation is usually the prerogative of terminal iron carbene complexes, while dimetallic, bridging carbenes tend to retain bridging acyl ligands after 1,1 migratory insertion of CO. Observations at -40 °C showed that an acyl intermediate could evolve into a ketene and form a stable μ2-alkylidene di-iron hexacarbonyl complex. Ketene release was shown to depend on the redox state of the iron byproducts. The CC bond formation is reversible, with instant hydration-decarboxylation upon water addition at room temperature
Ultra-high-resolution imaging of NHP head at 11.7T with a 32-channel Honeycomb modular receive array
No full textInternational audienceMotivation: Our operational 11.7T recently delivered the first in-vivo human brain images. Yet, non-human-primate (NHP) brain is also of interest to the neuroscientists because of its similarity to human.Goal(s): To establish ultra-high-resolution whole-brain imaging for NHP at 11.7T using a 32-Rx coil.Approach: A 32-channel receive array, initially designed for human brain temporal lobes, was adapted to the NHPthanks to repositionable high-impedance loops and an adaptative former.Results: In-plane resolutions below 100 µm were achieved.Impact (<40): The modularity of our receivers allows to image both human and non-human primate brains withoutthe need for coil retuning. Ultra-high-resolution MRI of whole-head anesthetized NHP is demonstrated at 11.7T
Causal Meta-Analysis: Rethinking the Foundations of Evidence-Based Medicine
No full textMeta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed-or random-effects models lack a causal framework, which may limit their interpretability and utility for public policy. Incorporating causal inference reframes meta-analysis as the estimation of well-defined causal effects on clearly specified populations, enabling a principled approach to handling study heterogeneity. We show that classical meta-analysis estimators have a clear causal interpretation when effects are measured as risk differences. However, this breaks down for nonlinear measures like the risk ratio and odds ratio. To address this, we introduce novel causal aggregation formulas that remain compatible with standard meta-analysis practices and do not require access to individual-level data. To evaluate real-world impact, we apply both classical and causal meta-analysis methods to 500 published meta-analyses. While the conclusions often align, notable discrepancies emerge-revealing cases where conventional methods may suggest a treatment is beneficial when, under a causal lens, it is in fact harmful