HAL Université de Tours
Not a member yet
55851 research outputs found
Sort by
« Des images qui font tapisserie : les gravures anglaises dans les intérieurs allemands du XIXe siècle »
No full textInternational audienc
Neuropsychological profile of French adults with early-treated phenylketonuria: a multicenter study
No full textInternational audienceBackground and objective: Adult patients with early-treated phenylketonuria (AwET-PKU) may present some subtle neurocognitive deficits. The aim of the study was to investigate 1) neurocognitive functions in a large group of AwET-PKU 2) the influence of plasma phenylalanine (Phe).Methods: Participants: 187 AwET-PKU (classic PKU [cPKU] 81%, mild PKU [mPKU] 14%, and mild persistent hyperphenylalaninemia [MPH] 5%). Cognitive assessments: tests included the Wechsler Adult Intelligence Scale-IV, California Verbal Learning Test-II, Trail Making Test, and verbal fluency tests. Biochemical data: plasma Phe was measured concurrently with cognitive assessments.Results: Episodic memory: cPKU patients had lower performance in immediate recall compared to mPKU patients. There was a negative correlation between Phe levels and immediate recall indices, but no correlation with delayed memory. Processing speed: cPKU patients performed worse than mPKU patients in processing speed tests. Negative correlations were observed between Phe levels and processing speed measures, with more pronounced effects in cPKU patients. Executive functioning: No differences were found between cPKU and mPKU patients on executive functioning tests. No correlation was found between executive function and Phe levels. Working memory: cPKU patients had poorer working memory performance compared to mPKU patients, though no correlation was found between working memory performance and Phe levels.Conclusions: The study reveals neurocognitive deficits in adults with PKU, particularly in episodic memory and processing speed. Higher plasma Phe levels are associated with poorer performance in these areas, especially in cPKU patients. Working memory and executive functioning did not show significant correlations with Phe levels
La diffusion du droit de l'Union européenne à travers les conditions de l'activité économique
No full textInternational audienc
Dynamiques de Gouvernance dans l'Écosystème des Start-ups Innovantes
No full textInternational audienc
Bioconjugation systems and uses thereof
No full textThe present invention relates to a compound having the following formula (I) wherein: - A represents an aryl or heteroaryl group, - n is 1 or 3, - L1 represents a linear or branched alkylene radical, comprising from 2 to 20 carbon atoms, - L2 represents a release system, and - L3 represents an anticancer agent
Enhanced Condensation Through Rotation
No full textInternational audienceWe argue that the rotation of a thin superconducting cylinder can increase the critical temperature of the superconducting phase transition substantially. The phenomenon can be interpreted as an effective negative moment of inertia associated with condensation of Cooper pairs. We give quantitative estimates for a thin cylinder of aluminum
Linking Plant Diversity and Urban Uses at the City-Block Scale to Inform Urban Planning
No full textInternational audienceA challenge for urban ecology is to reduce biotic homogenisation by promoting plant diversity from local to city scales. As ecological and social components constantly interact in cities, an urban landscape characterisation reflecting socio-spatial functioning seems essential. However, spatially explicit description of cities at a relevant scale for urban planning are uncommon in ecological studies. Here, we explored a new approach based on the city-block scale, common in urban geography and planning, to directly link urban uses and patterns of herbaceous plant communities. We characterised all city blocks of a mediumsized French city (Blois). We inventoried grassland and meadows in 129 city blocks (10% of the whole city) for seven public and private urban uses (collective housing, individual housing, industrial, public service, park, land reserve, and road verge). We measured alpha diversity, community composition, regional originality of urban uses, and beta diversity between them. Urban land reserved for future development and parks harbour unique community composition within the city. Collective and individual housings have the same average alpha diversity, but the variability in community composition was higher for individual housing blocks. School and industrial city blocks have important alpha diversity and regional originality. Road verges have the highest alpha diversity but low regional originality and many common urban and regional species. Large green spaces with original communities should be protected during urban densification. The verticalization of residential housing could be an efficient means of internal urban densification if the lowest level of management intensity is promoted to maintain diversified vegetation. Some little-studied uses (schools, industrial city blocks) present opportunities to impede urban homogenisation
Multiscale analysis of existing actual evapotranspiration products over agropastoral Sahel
No full textInternational audienceUnderstanding the spatiotemporal variability of actual evapotranspiration (ET) is a critical issue for better water resources management from plot to basin scale. It is particularly true in the Sahelian region which is very vulnerable in terms of water and agricultural resources, but also very scarcely monitored. This study aims to improve understanding of ET in Sahelian agrosystems by comparing twenty ET products and collections on two areas in Central Senegal and South-Western Niger: Breathing Earth System Simulation (BESS), Derive Optimal Linear Combination Evapotranspiration (DOLCE) v2.1 and v3.0, ERA5 and ERA5-Land, FLUXCOM-RS, Global Land Data Assimilation System (GLDAS) on Noah and Catchment Land Surface Model (CLSM), Global Land Evaporation: the Amsterdam Methodology (GLEAM) v3.5a, v3.5b, v3.6a and v3.6b, Modern-Era Retrospective analysis for Research and Applications v2 (MERRA-2), MODIS Global Evapotranspiration products (MOD16/MYD16), Penman-Monteith Leuning version 2 (PML_V2) v0.1 and v0.1.7, Reliability Ensemble Averaging (REA), Simplified Surface Energy Balance for operational applications (SSEBop) and Water Productivity through Open access of Remotely sensed derived data (WaPOR). In order to assess the abilities and drawbacks of each product, a multi-scale analysis is first performed at local scale with different temporal aggregation levels (daily, decadal, monthly). The best performing products, like GLEAM, MERRA-2 or GLDAS-Noah, have low spatial resolution (≥0.25°), but shows really good agreement with ET measurements (RMSE ∼ 0.5 mm.d-1, R2 ≥ 0.8). A multi-scale spatial analysis with different spatial aggregation levels (1, 10 and 25 km) is then performed on interannual composite maps of annual and seasonal ET. Results highlight the different spatiotemporal behaviour of all the products. Products such as ERA5-Land and PML_V2 0.1.7 stand out in this comparison as their higher resolution allows them to describe the spatial patterns of ET realistically and more precisely while having relatively good performances at local scale (RMSE ∼ 0.6 mm.d-1, R2 ≥ 0.7). Overall, the comparison highlights the need to consider soil moisture to accurately estimate ET in the Sahelian region, as the products considering it generally show better performances. It also points out the lack of a high quality and resolution ET product over the Sahel. Future satellite missions, as well as data fusion techniques, could help to fill up this gap and propose a reference product on Sahelian ecosystems
(Re)production d'une capitale dans une république de 100 ans: Ankara
No full textInternational audienc