HAL Université de Tours
Not a member yet
55851 research outputs found
Sort by
Le régime des dommages-intérêts non compensatoires – Rapport de synthèse
No full textInternational audienc
A structural survey and examination of lanthanide emission from gallium-containing metallacrowns with folded and collapsed motifs
No full textInternational audienc
« Les graffitis historiques : brève histoire d’un objet archéologique nouveau »
No full textInternational audienc
Identité du trio de piano au XXIe siècle : persistance ou désintégration de la mémoire ?
No full textInternational audienceIn the 21st century, countless piano trios have emerged across five continents in the field of jazz. There seems to be a particular persistence of the format, whose direction was embodied at the turn of the century by the Avishai Cohen Trio, Bad Plus, and E.S.T., among others. According to Pierre Sauvanet, for example, “the jazz trio embodies a musical group so coherent that it becomes a kind of sound form in its own right.” However, given its increasingly diverse and varied forms, it is worth questioning the current reality of this phenomenon, and first and foremost the degree of emancipation it demonstrates (through the words of its performers and their musical implementation) from the historical model of the jazz piano trio. Does the permanent research laboratory that this formation seems to constitute (and which therefore reinforces its centrality) renew or not, in the 21st century, the paradigm forged in the last century? The hypothesis examined in this presentation will be that the contemporary identity of the art of the trio highlighted by Brad Mehldau maintains a paradoxical link with its history, multiplying the points of contact between respect for and emancipation from tradition. After highlighting the phenomenon and illustrating the most salient aspects of its recent developments, we will attempt to show how two unique trios—Bad Plus in the United States and Punkt. Vrt. Plastik in Europe—shed light on our questioning.Au XXIe siècle, au sein du champ jazzistique, on ne compte plus les trios avec piano apparus sur les cinq continents du globe. Il semble ainsi y avoir une persistance particulière du format dont les orientations furent incarnées au tournant du siècle par le trio d’Avishai Cohen, Bad Plus, ou E.S.T., parmi d’autres. Selon Pierre Sauvanet, par exemple, « le trio jazz incarne un groupe musical si cohérent qu’il devient une sorte de forme sonore à lui tout seul . »Toutefois, au vu de ses déclinaisons toujours plus diverses et variées, il convient de s’interroger sur la réalité actuelle de ce phénomène, et en premier lieu sur l’émancipation plus ou moins grande dont il témoigne (à travers les propos de ses acteurs comme dans leur mise en œuvre musicale) par rapport au modèle historique du trio de piano. Le laboratoire de recherche permanent que semble constituer cette formation (et qui de ce fait en renforce la centralité) renouvelle-t-il ou non au XXIe siècle le paradigme forgé au siècle dernier ? L’hypothèse examinée au cours cette intervention sera que l’identité contemporaine de l’art of the trio mis en exergue par Brad Mehldau entretient un lien paradoxal avec son histoire, multipliant les points de contact entre respect et émancipation de la tradition. Après la mise en évidence du phénomène et l’illustration des aspects les plus saillants de ses évolutions récentes, nous essaierons de montrer comment deux trios singuliers – Bad Plus aux États-Unis, Punkt. Vrt. Plastik en Europe – éclairent notre questionnement
Unraveling variability in young children’s brain responses to varied sensory stimulations
No full textInternational audienceEarly childhood is a sensitive period of development, marked by high between and within individual variability in the acquisition of cognitive and social abilities. Our aim was to characterize electrophysiological individual sensory profiles of young children with electroencephalography. We recorded visual, auditory, and somesthetic event-related potentials (ERPs) to low-level, complex, and social sensory stimulations in 23 children (13 girls) without neurodevelopmental disorders (mean age: 47.8 months (±10.5) [30 64]). For each participant and condition, we analyzed ERPs' peak amplitudes and latencies and inter-trial consistency (ITC) as a measure of intra-individual variability. A hierarchical cluster analysis, following a principal-component analysis including all ERP measures, revealed 3 clusters; cluster separation was explained by mean ITC level. Neither age nor sensory-cognitive profiles explained cluster membership. Neurophysiological sensory profiles of young children differ mainly according to visual and auditory processing of complex information and do not rely solely on chronological age.</div
Explicit Edge Length Coding to Improve Long Sentence Parsing Performance
No full textLowResNLP 2025. The 1st Workshopon Advancing NLP for Low-Resource LanguagesAssociated with the International ConferenceRecent Advances in Natural Language ProcessingRANLP’2025 / PROCEEDINGSVarna, Bulgaria13 September 2025Online ISBN 978-954-452-100-4 /// https://acl-bg.org/proceedings/2025/LowResNLP%202025/2025.lowresnlp-1.pdfInternational audiencePerformance of syntactic parsers is reduced for longer sentences. While some of this reduction can be explained by the tendency of longer sentences to be more syntactically complex as well as the increase of candidate governor number, some of it is due to longer sentences being more challenging to encode. This is especially relevant for low-resource scenarios such as parsing of written sources in historical languages (e.g. medieval and early-modern European languages), in particular legal texts, where sentences can be very long whereas the amount of training material remains limited. In this paper, we present a new method for explicitly using the arc length information in order to bias the scores produced by a graph-based parser. With a series of experiments on Norman and Gascon data, in which we divide the test data according to sentence length, we show that indeed explicit length coding is beneficial to retain parsing performance for longer sentences
In Vitro and Ex Vivo evidence that pharmacological induction of the hypoxia response pathway efficiently restricts measles and Nipah virus infections
No full textInternational audienceAirborne RNA viruses of the Paramyxoviridae family are major human pathogens. These include measles virus (MeV) and Nipah virus (NiV), the latter being on the World Health Organization's blueprint list due to its high case-fatality rate and critical risk of emergence. Although an effective vaccine is available for MeV, this is not the case for NiV. Moreover, there is no cure for MeV-or NiV-infected patients that prevents the acute respiratory syndrome or lethal encephalitis. To identify new host factors to target for inhibiting viral growth, a library of metabolic modulators was screened for activity against MeV using an in vitro infection model. Results showed that Molidustat, a pharmacological inhibitor of Prolyl-Hydroxylase Domain (PHD) enzymes, inhibits MeV infection in a Hypoxia-Inducible Factor (HIF)-dependent manner. We then tested the antiviral effect of Molidustat in organotypic cultures of hamster cerebellum. Molidustat induced the hypoxiaresponse pathway in this ex vivo model as assessed by transcriptomic analysis, and inhibited MeV infection. A similar antiviral effect was observed with Roxadustat and Daprodustat, two PHD enzyme inhibitors chemically unrelated to Molidustat. Finally, we showed that Molidustat inhibits NiV infection in organotypic cultures of hamster cerebellum and lung, thereby validating its effect in the two organs mainly targeted during infection. Taken together, our results provide evidence that pharmacological activation of the hypoxia-response pathway restricts MeV and NiV infections, highlighting HIF-inducing drugs as promising candidates to consider in the development of treatments
Short-term immobilization impairs direction programming and control of pointing movements
No full textInternational audienc
A narrative review of potential therapies for the treatment of myocardial tissue in relation to heart failure
No full textInternational audienceHeart failure (HF) is not a disease but a combination of signs and symptomscaused by the failure of the heart to pump blood to support the circulatory system atrest or during activity. HF is the potential end stage of all heart diseases in whichcardiomyopathies are a diverse group of cardiac disorders with distinct phenotypes,depending on the protein and pathways affected. Cardiomyopathies representmajor causes of morbidity and mortality at all ages in humans in which hypertrophiccardiomyopathy (HCM) and dilated cardiomyopathy (DCM), are the most common.Among the different common diagnostic tests for heart failure such as physicalexamination, blood tests, chest X-rays, electrocardiogram (ECG), etc. ultrasound hasalso been used not only for diagnosis such as echocardiography but also fortherapeutic purposes. The development of therapeutic strategies for HF aiming toimprove the heart’s function, delay progression of HF, and treat HF symptoms aswell as to stimulate the capacity to regenerate cardiomyocytes via stem cell therapyhave been under intensive research interest. This narrative review aims to presentthe current understanding of the pathogenesis, diagnosis, and treatment of HF.Furthermore, as a perspective, this review navigates emerging therapies for HF byemphasizing on the use of low-intensity pulsed ultrasound (LIPUS) as a noninvasivetherapy for (1) stimulation of the myocardial tissue reconstructionmechanisms; and (2) exploration of the molecular mechanisms behind themechanotransduction from the muscle LIM protein (MLP), which is believed to beinvolved in human HF, using its expression vector via glycosylphosphatidylinositol,GPI, anchor