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Вивчення жирнокислотного спектру сироватки крові хворих на аспіринасоційований поліпозний риносинусит
Full text linkAim of research – to study the composition of the main representatives of polyunsaturated and saturated fatty acids in blood serum of patients with chronic polypous rhinosinusitis, associated with intolerance to acetylsalicinic acid.Materials and methods. The fatty-acid composition of blood serum was determined by the method of capillary gas-liquid chromatography in 20 ill and 7 healthy donors.Results: The change of composition of unsaturated fatty acids is in increase of arachidonic acid level, decrease of the content of its main predecessors – linoleic and eicosapentaenoic acids, normal level of intermediate products:α – and γ – linoleic acid and increase of the level of oleic acid. The content of the main saturated fatty acids: palmitic, stearic, arachidic ones is increased. The fatty acids imbalance testifies to the proinflammatory directionality of lipid metabolism.Conclusions:1. The increase of the level of polyunsaturated (arachdonic and oleic acids) leads to the compensatory decrease of the level of the main predecessors of arachinonic – linoleic and eicosapentaenoic acids. This mechanism allows keep the intermediate products of synthesis of arachidonic acid - α – and γ – linoleic acids at the normal level.2. The content of saturated fatty acids with alternative biological effects is increased in blood serum as a compensatory mechanism of leveling of biological effects of polyunsaturated fatty acids and their metabolites,.3. The revealed imbalance of fatty acids testifies to the proinflammatory directionality of the lipid metabolism.4. The changes of fatty-acid spectrum of lipids in the blood serum prove the hypothesis of “genetic block COG1” as the main pathogenetic link of aspirin associated polypous rhinosinusitisМета роботи – вивчення жирнокислотного спектру сироватки крові пацієнтів з аспіринасоційованим поліпозним риносинуситом. Виявлено: дисбаланс поліненасичених: збільшення рівня арахідонової та олеїнової, нормальний рівень α – та γ – ліноленової, знижений рівень лінолевої та ейкозапентаєнової кислот; збільшення вмісту насичених: пальмітинової, стеаринової, арахінової кислот. Виявлений дисбаланс жирних кислот свідчить про прозапальну спрямованість обміну ліпіді
Дослідження особливостей копінг-поведінки хворих з вугровою хворобою
Full text linkAcne is an urgent problem of the modern dermatology and psychodermatology. It most patients near 20 years acne regresses, but in 10 – 20 % of them dermatosis becomes chronic.Aim of research – to study the features of coping-behavior of patients with acne.Materials and methods. 142 patients with chronic acne took part in the research – the main group (MG): 75 patients of female and 67 ones of male sex, and 70 interrogated without dermal or any other chronic somatic pathology – the group of comparison (GC), 35 girls and 35 boys respectively. The questionnaire by R. Lazarus “The ways of overcoming behavior” was used as a diagnostic instrument.Results of research. In the research was revealed that coping of patients with acne is characterized with expressed directionality on the search for social support, overcoming of the negative feelings at the expense of subjective lowering of significance and emotional involvement as to the stress event, reaction by escaping type. Patients with acne are inclined to use the conventionally adaptive and non-adaptive coping forms. The types of anti-stress activity in men and women differ.Conclusions. The established features indicate the necessity to take into account the features of behavior patterns at elaboration of model of medical-psychological help for patients with acne and differentiation of psychological influences depending on type of stress-overcoming behaviorКопінг хворих на вугрову хворобу характеризується виразною спрямованістю на пошук соціальної підтримки, подолання негативних переживань за рахунок суб’єктивного зниження їх значимості, реагування по типу уникнення. Пацієнти з акне схильні застосовувати умовно-адаптивні та неадаптивні форми копінгу. У жінок та чоловіків профілі антистресової активності відрізняються. Особливості копінгу є важливими мішенями медико-психологічного вплив
Аналіз особливостей прояву афективно-невротичної симптоматики у пацієнтів косметологічного профілю
Full text linkThe significant prevalence of psychic pathology among patients of the medical sphere, including medical cosmetology puts a question about organization of medical-psychological help for this category of patients/clients.Aim of research – to reveal the features of the structure of affective-neurotic psychopathological symptoms in cosmetological patients.Contingent and methods of research. The testing included 286 women, who asked for cosmetological help. The interrogated were divided in three groups on the base of self-relation criterion: 1 group included persons with disharmonious type with tendency to the understated self-appraisal (G1, n=108), 2 group – with harmonious type (G2, n=96) and 3 group – with disharmonious type with inclination to the overstated self-appraisal (G3, n=82). Determination of the intensity of psychopathological symptoms was carried out by the SCL-90-R method.Results. The main manifestations of affective-neurotic symptoms in women with disharmonious type of self-relation with inclination to understated self-appraisal were somatization on astheno-neurotic type, the expressed anxiety component (worry, strain, fear, waiting for troubles, excessive bother), indecisiveness, need to verify the own actions, intrusive ideas, lack of forces, hypothymia, self-accusation, feeling of necessity of excessive efforts for own activity, discomfort in populous places; in patients with inclination to overstated self-appraisal – somatization with illogical and hysteroid manifestations, strain, nervousness, excessive bother, intrusive ideas, feeling of loneliness, depression. In women with harmonious self-relation somatization was manifested mainly by cephalalgias, strain, less nervousness, intrusive ideas, the necessity to verify the own actions and hypothymia. The structure of psychopathological symptoms in cosmetological patients reflected the meaningful features and directionality of psychic reaction to stress.Conclusions. The women, who ask for the medical care, form the group, heterogenic by psychological characteristics that must be taken into account at giving medical and psychological help. The patients with disharmonious type of self-relation, especially the ones with inclination to understated self-appraisal, form the risk group as to the psychic health and need medical-psychological helpЖінки, які звертаються за косметологічною допомогою – неоднорідна за психологічними характеристиками групи. Рівень вираженості психопатологічної симптоматики, структура окремих психопатологічних симптомів різняться залежно типу самовідношення: гармонійного, дисгармонійного зі схильністю до заниженої чи завищеної самооцінки. Структура психопатологічних симптомів у пацієнток косметологічного профілю відображає змістовні особливості переживання психічного стресу, важливі для надання медико-психологічної допомог
Застосування методик електронейрографії для визначення невропатичного компоненту болю у пацієнтів з хронічними больовими синдромами попереково-крижової локалізації
Full text linkAim of research: to study the possibility to use the separate methods of electroneurography, namely nociceptive flexor reflex (NFR) for determination of neuropathic component of pain in patients with the chronic pain syndrome of lumbar-sacral localization.Materials and methods: 103 patients with the chronic vertebrogenic lumbar-sacral pain syndrome (CVLSPS) and 30 practically healthy persons were examined. According to the results of clinical-neurological examination all patients were divided in groups that corresponded to the first four groups of Classification of spine disease of Quebec special commission (CSDQSC). The determination of state of peripheral neuromotor apparatus was realized using electroneurography of the calf nerve, after that the NFR study was realized.Results: the speeds of impulse passing on the calf nerve did not differ between patients with CVLSPS and the control group. The reliable decrease of pain threshold (PT) (7,65±1,77), reflex threshold (RT) (9,67±2,0) and ratio of pain threshold/reflex threshold (PT/RT) (0,77±0,11) were revealed in the group of patients with CVLSPS comparing with the group of practically healthy examined persons (8,90±0,94, 10,38±1,05 and 0,86±0,07 respectively). At the analysis of NFR parameters between the groups of patients with CVLSPS the statistically significant differences in PT and RT parameters were not found. PT/RT ratio was statistically reliably lower in IV group (0,73±0,12) comparing with other three groups of patients.Conclusions: patients with CVLSPS have the reliably lower values of PT and RT and PT/RT ratio comparing with practically healthy persons. PT/RT ratio is the most specific parameter of NFR for differentiation of nociceptive and neuropathic pain componentsУ статті висвітлюється досвід застосування окремих методик електронейрографії, а саме ноцицептивного флексорного рефлексу, для визначення невропатичного компоненту болю у пацієнтів з хронічними больовими синдромами попереково-крижової локалізації. Доведена придатність цього методу та показані значення основних, важливих для клінічної практики, показників у групі пацієнтів та практично здорових випробовувани
Стан слизової оболонки шлунка у хворих на хронічний гастрит в поєднанні з остеоартрозом в умовах терапії нестероїдними протизапальними препаратами
Full text linkAim of research. To detect the features of histopathological changes of gastric mucosa (GM) in patients with chronic gastritis (CG) associated with osteoarthritis (OA) under conditions of NAP-therapy.Materials and methods of research. The complex examination was carried out in 507 patients, 40 - 65 (52,5±4,32) years old, including 310 women and 197 men. All patients were divided in 2 clinical groups: 1 group included 357 patients with OA, associated with CG, 2 group ‒ 150 patients with CG without joint pathology. Then the patients with CG of both groups were divided depending on the presence of atrophy and its stage: non-atrophic gastritis (NAG) took place in 117 and 51 patients from І and ІІ groups, respectively; initial atrophy (IA) that corresponds to the I and II stage of atrophy, according to OLGA system, was detected in 128 and 54 patients from І and ІІ groups, respectively; the heavy atrophy (HA) that corresponds to ІІІ and ІV stage of atrophy, according to OLGA system, was fixed in 112 and 45 patients from І and ІІ groups, respectively.Нp-infection was detected using two methods: fast urease test and cystoscopy of smears of imprints, colored according to Romanovsky-Gimza. The half-quantity assessment of inflammatory infiltrate and of the stages of atrophic changes intensity was carried out in GM histological preparations, received from the antral part and gastric body, using visual-analogous scale.Results of research. At the comparison of Нр- colonization frequency between groups it was established, that the number of Нр – positive patients with NAG among I group was 1,5 times less (c2=8,14, р=0,032), than in ІІ group. It was established, that in І group at both non-atrophic and atrophic gastritis Нр-infection did not influence the intensity of disease. But at CG without concomitant pathology the integral index of inflammation in Нр-positive persons was 1,8 times higher (р<0,05), than in Нр-negative ones. The decrease of GM parenchyma thickness was observed in patients of both groups at the atrophy progression: in I group with AG the GM thickness in gastric body was 1,5 less than at NAG (р<0,05), the increase of stroma part in 1,6 times (р<0,05) comparing with NAG was observed in II group at AG.Conclusions. At NAG, associated with OA the number of Нр – positive patients was 1,5 times less (c2=8,14, р=0,032), than among patients with NAG without associated pathology. The intensity of inflammation in GM at CG in combination with OA in Нр-positive and Нр-negative patients did not essentially differ, at the same time at CG without concomitant pathology the integral index of inflammation in Нр-positive persons was 1,8times higher(р<0,05), than in Нр-negative ones. The progression of GM atrophy was characterized with the decrease of parenchyma thickness, not depending on concomitant pathologyВ результаті проведеного дослідження встановлено, що перебіг хронічного гастриту у хворих хронічний гастрит (ХГ), які отримують селективні НПЗП з приводу супутнього остеоартрозу характеризується зменшенням інтенсивності запалення у слизової оболонки шлунка (порівняно з пацієнтами на ХГ без супутньої патології) та збільшенням частки строми, паралельно з прогресуванням атрофічних змі
Особливості копінгу у пацієнтів косметологічного профілю з дисгармонічним самовідношенням та завищеною самооцінкою
Full text linkAim of research was to reveal the features of stress-overcoming behavior of cosmetic patients with disharmonic self-attitude and heightened self-esteem.Contingent and methods. The research was carried out on the base of medical center “CA-CLINIC” (city Kyiv) during 2014 – 2016. The testing included 188 women, who asked for cosmetic help. The interrogated were divided in groups on the base of criterion of self-attitude: the main group included persons with disharmonic type with tendency to heightened self-esteem (MG, n=82), the control group included women with harmonic type (CG, n=96). Psychodiagnostic instrument was the questionnaire of the “Ways of overcoming behavior” by R. Lazarus and S. Folkman.Results. For the women with disharmonic type of self-attitude and heightened self-esteem was typical the following features. The main factors of stress-overcoming behavior were confrontation and search for social support, less expressed were distancing, self-control, responsibility, planning and least expressed was the positive reassessment. The higher levels of confrontation and distancing and the lower one of positive reassessment comparing with women with harmonic type of self-attitude were revealed. The coping-profile was manifested by impetuosity, active behavior at solving problems that could lose the character of purposefulness, rigid vindication of interests, difficulties in re-formulation of personal settings, indisputability of own position, need of involvement of social resources for attraction of attention, information, active help, emotional inclusion and devaluation of problem, rationalization, ability to control oneself, to plan. The feature of coping was the growth of tension of non-adaptive and conventionally adaptive and decrease of adaptive forms of coping, presence of strategies of stress-overcoming behavior, opposite by content that totally conditioned the decrease of effectiveness in overcoming of stress.Conclusions. The features of stress-overcoming behavior in women with disharmonic self-attitude and heightened self-esteem indicated the necessity of psychic correction within the complex program of medical-psychological helpКопінг-профіль жінок з дисгармонічним самовідношенням та завищеною самооцінкою визначався напористістю, активною поведінкою у вирішення проблем, яка могла втрачати характер цілеспрямованості, відстоюванням інтересів, труднощами у переформулюванні особистісних установок, беззаперечністю власної позиції, потребою у залученні соціальних ресурсів для отримання уваги, інформації, дієвої допомоги, зниженням суб’єктивної значимості, знеціненні проблем, раціоналізації, самоконтролем, стратегічним планування