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[Weslaco] Photograph of Cortez Hotel
No full textCortez Hotel located on 3rd and South Texas.https://scholarworks.utrgv.edu/hidalgohist_aa/1505/thumbnail.jp
[Weslaco] Photograph of Relift Pump and Diesel Engines
No full textView of relift pump and diesel engines.https://scholarworks.utrgv.edu/hidalgohist_aa/1688/thumbnail.jp
[Homesteads] Photograph of Mexican Home Jacal
No full textA man and two goats in front of a mexican home jacal.https://scholarworks.utrgv.edu/hidalgohist_aa/1719/thumbnail.jp
[Mission] Photograph of Citrus Fiesta Parade
No full textCitrus Fiesta Parade on Conway Avenue in Mission, Texas.https://scholarworks.utrgv.edu/hidalgohist_aa/1718/thumbnail.jp
[Mercedes] Photograph of Rio Grande Grain Co. Feed Store
No full textRio Grande Grain Co. Feed Store.https://scholarworks.utrgv.edu/hidalgohist_aa/1488/thumbnail.jp
[Donna] Photograph of Donna Hooks Fletcher
No full textPortrait of Donna Hooks Fletcher (1879-1969).https://scholarworks.utrgv.edu/hidalgohist_aa/1655/thumbnail.jp
Global dynamics of cubic Cherkas systems with Z 2 -equivariance (Ⅰ): The saddle case
No full textIn this paper, we investigate bifurcation diagrams and global phase portraits on the Poincaré disc for a cubic Cherkas system with symmetry. When the sum of indices of equilibria is −1, we obtain some interesting dynamical behaviors, including Hopf bifurcation, heteroclinic bifurcation, saddle-node bifurcation, and saddle connection bifurcation. These results greatly enrich the dynamics of planar nonlinear differential systems and demonstrate different features
Nifuroxazide and 4-Hydroxybenzhydrazone Derivatives as New Antiparasitic (Trypanosoma cruzi and Leishmania mexicana) and Anti-Mycobacterium tuberculosis Agents
Get PDFBackground/Objectives: Nifuroxazide (Nfz) is a drug that has been used as a scaffold for designing antimicrobial and antiparasitic agents. This study aimed to synthesize and evaluate in vitro of Nfz and twenty-five 4-hydroxybenzhydrazone derivatives as potential anti-Trypanosoma cruzi, anti-Leishmania mexicana, and anti-Mycobacterium tuberculosis agents.
Methods: The compounds were synthesized by condensing 4-hydroxybenzhydrazide with appropriate aldehydes in acidic conditions and structurally confirmed by spectroscopic techniques. All compounds were evaluated in vitro against T. cruzi strains (NINOA and A1), L. mexicana (M379 and FCQEPS strains), and M. tuberculosis (H37Rv strain), followed by enzymatic assays against T. cruzi cysteine proteases.
Results: Compound Nfz-24 (IC50 = 6.8 μM) had better trypanocidal activity than the reference drugs benznidazole (IC50 \u3e 30 μM) and nifurtimox (IC50 \u3e 7 μM) against the NINOA strain, and Nfz-8 (IC50 = 7.2 μM) was the compound most active against the A1 strain with a high inhibition of T. cruzi cysteine proteases (IC50 = 4.6 μM) and low cytotoxic effects (CC50 \u3e100 μM). On the other hand, compound Nfz-5 (IC50 = 5.2 μM) had a 25-fold better leishmanicidal effect than glucantime (IC50 \u3e 125 μM) against the L. mexicana M379 strain, and compound Nfz-13 had the best leishmanicidal effects (IC50 = 10.2 μM) against the FCQEPS strain. Finally, Nfz, Nfz-1, and Nfz-2 had minimum inhibitory concentration (MIC) values of 12.3, 5.1, and 18.8 μg/mL against M. tuberculosis, respectively.
Conclusions: In summary, these results suggest that the compounds Nfz-1, Nfz-2, Nfz-5, Nfz-8, Nfz-10, Nfz-15, Nfz-24, and Nfz-25 are candidates for further studies to develop new and more potent anti-T. cruzi, anti-leishmaniasis, and anti-M. tuberculosis agents
CEO cultural heritage and corporate social responsibility
No full textWe examine the impact of CEOs\u27 cultural heritage on corporate social responsibility. CEOs originating from countries with high Power Distance have high CSR scores, while those originating from Individualistic and Indulgent cultures have low CSR scores. This effect lasts up to three generations before it disappears due to acculturation. These results are robust to using propensity score matching, entropy balancing, Difference-in-Differences (DiD) estimation around CEO turnover, and a subsample of founder CEOs to address endogeneity and selection bias. Our findings shed light on the formation process of managers\u27 intrinsic motives for prosocial behavior and hence improve our understanding of insider-initiate corporate philanthropy
Unveiling Mycobacterium fortuitum Lung Disease: A Case Linked to Pedicure Practices
Get PDFMycobacterium fortuitum (M. fortuitum) is a rapidly-growing mycobacterium (RGM) that can lead to a variety of infections affecting the lungs, skin, and soft tissue. Pulmonary infections with M. fortuitum primarily affect individuals with pre-existing lung conditions, although exposure through contaminated water sources, such as pedicures and nail salon whirlpool footbaths, has also been documented. We present a case of a previously healthy young male presenting with respiratory symptoms and systemic signs suggestive of infection. Following extensive diagnostic workup, M. fortuitum was identified in sputum samples, leading to a favorable response to targeted antibiotic therapy. This case underscores the importance of considering M. fortuitum in differential diagnoses of pulmonary infections and skin infections, particularly in patients without known risk factors