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Photograph of Fuera ICE, Trump, y Monica de la Cruz Sign
No full textPhotograph of Fuera ICE, Trump, y Monica de la Cruz Signhttps://scholarworks.utrgv.edu/spanglishrgv/1033/thumbnail.jp
Photograph of Friends Across Borders Posters
No full textPhotograph of Friends Across Borders posters (San Juan, TX)https://scholarworks.utrgv.edu/spanglishrgv/1030/thumbnail.jp
Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study
No full textBackground
Structural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical control individuals (NCs). Most previous studies examined the thalamusas a whole as a single region of interest. In addition, findings in individuals at familial high risk for SCZ (FHRs) remain inconclusive. Here, we investigated whether local and network-wide thalamic-related structural alterations vary as a function of familial risk for SCZ. Methods
Structural magnetic resonance imaging scans were obtained from 5197 participants (NC, n = 3409; FHR, n = 257; SCZ, n = 1531) across 32 cross-sectional samples within the ENIGMA (Enhancing Neuro ImagingGenetics through Meta Analysis) Consortium. Random-effects meta-analyses and network analyses were conducted on 1) local thalamic alterations (volume estimates of 7 thalamic subdivisions) and 2) network-wide thalamic alterations (thickness and surface-related thalamocortical/corticocortical covariation patterns) across groups (NC, FHR, SCZ). Results
Individuals with SCZ showed significantly lower gray matter volume estimates in the anterior, pulvinar, medial, posterior, and ventral thalamic subdivisions compared with NCs (false discovery rate–corrected q [qFDR] \u3c .05). FHRs did not differ from NCs. At the network-wide level, thalamocortical covariations discriminated FHRs from NCs (qFDR \u3c .05), with FHRs showing intermediate covariation between individuals with SCZ and NCs. Corticocortical covariation patterns revealed that individuals with SCZ and FHRs shared similarly disconnected clustering configurations, distinct from NCs (qFDR \u3c .05). Conclusions
Results revealed lower thalamic volume estimates in individuals with SCZ but not in FHRs, hence yielding no evidence of a familial risk trait, whereas thalamocortical and corticocortical covariation estimates were associated with familial risk for SCZ. These findings suggest that, once the thalamus is parsed into subdivisions, network-wide thalamocortical features may identify trait-dependent, neurobiological correlates of genetic risk for SCZ
Photograph of Panadería Ad
No full textPhotograph of Panadería Ad (San Juan, TX)https://scholarworks.utrgv.edu/spanglishrgv/1039/thumbnail.jp
Photograph of El Pastor Mexican Grill Sign
No full textPhotograph of El Pastor Mexican Grill sign (McAllen, TX)https://scholarworks.utrgv.edu/spanglishrgv/1042/thumbnail.jp
Photograph of La Michoacana Meat Market
No full textPhotograph of La Michoacana Meat Market (McAllen, TX)https://scholarworks.utrgv.edu/spanglishrgv/1055/thumbnail.jp
Photograph of El Fenix Bakery
No full textPhotograph of El Fenix Bakery (Edinburg, TX).https://scholarworks.utrgv.edu/spanglishrgv/1058/thumbnail.jp
What if the swans wreaking havoc in supply chains are grey not black?
No full textGrey Swan is a relatively new construct that has not been adequately operationalised in supply chain management research. This work provides a supply chain management explanation and perspective on Grey Swans by distinguishing their characteristics relative to their more inconspicuous kindred, the Black Swans. Predictability and consequences are used to differentiate between the types of risk represented by black and grey swan events, as these are precursors to a set of descriptive and prescriptive (normative) views resulting from two pilot studies. Pilot studies were conducted to establish the validity and reliability of four types of supply chain disruptions comprising: labour disputes, political instability, supplier insolvency and trade disputes. A framework with recommendations and proposed actions to lessen the effects of Grey Swans is formulated with examples of industries mitigating Grey Swans in supply chains. Ten anonymous experts with extensive managerial experience in supply chains participated in a Delphi study to validate and provide their views on the proposed framework, and their inputs were used to refine it. This work contributes to the body of knowledge comprising Grey Swans and their impact on supply chains by presenting a framework outlining strategies to aid decision-makers in mitigating the effects of Grey Swans
The hidden link between HIV and cardiomyopathy: unraveling HIV\u27s impact on the heart
No full textThis comprehensive review examines the complex relationship between human immunodeficiency virus (HIV) and cardiomyopathy, focusing on the underlying molecular mechanisms, clinical manifestations, diagnostic approaches, and treatment strategies. It highlights the significant global health burden posed by HIV and its potential to cause long-term cardiovascular complications. The review investigates the pathogenesis of HIV-associated cardiomyopathy. It elucidates the intricate cellular and molecular pathways involved, including the actions of neutrophils, monocytes, macrophages, and lymphocytes in cardiac inflammation. Key signaling pathways such as TNF-NF-κB and the caspase-1 inflammasome are detailed, as they contribute to cardiac infection and injury. The clinical manifestations of HIV-associated cardiomyopathy are discussed, including fatigue, dyspnea, peripheral edema, and arrhythmias. The review outlines essential diagnostic methods, highlighting the importance of cardiac biomarkers, electrocardiography, and imaging techniques such as echocardiography and cardiac MRI. Treatment strategies are explored, encompassing lifestyle modifications, pharmacological interventions, and advanced therapies. The review underscores the importance of addressing micronutrient deficiencies, particularly selenium, in the management of HIV-associated cardiomyopathy. It also discusses the role of antiretroviral therapy and the potential benefits of intravenous immunoglobulin therapy. Furthermore, this review addresses the evolving perspective on heart transplantation for individuals with HIV. It notes that while HIV was once considered a contraindication for transplantation, recent advancements in antiretroviral therapy have led to a re-evaluation of this stance. Finally, the review identifies future research directions, emphasizing the need for biomarkers to detect at-risk patients, exploration of nutritional factors predisposing individuals to cardiomyopathy, and further investigation into advanced therapies for HIV-associated cardiomyopathy. This review significantly enhances the understanding of HIV-associated cardiomyopathy, providing valuable insights for clinicians and researchers in the fields of infectious diseases and cardiology
BOARD # 273: NSF IUSE HSI Implementation and Evaluation Project: The Freshman Year Innovator Experience (FYIE): Bridging the URM Gap in STEM.
No full textThe University of X\u27s Freshman Year Innovator Experience (FYIE) program, hosted at a Minority Serving Institution (MSI), seeks to improve the first-year experience for new students by nurturing essential academic success skills. Specifically tailored to freshman mechanical engineering students, the program aims to equip them with self-transformation skills to navigate through the amplified academic and professional obstacles brought about by the COVID-19 pandemic. Participants of FYIE engage in two concurrent courses: Introduction to Engineering (Course A) and Learning Frameworks (Course B). In Course A, students undertake a 6-week engineering design project, while in Course B, they work on a 6-week academic career path project. Throughout these simultaneous projects, time-bound interventions highlight the similarities between the engineering design process and the academic career pathways project. The main goal is for students to recognize that the design thinking skills acquired in the engineering design process can be applied to resolve their academic career challenges. The FYIE program was initiated as a pilot in the spring semester of 2023, with instructors from Course A and B introducing the parallel projects. The implementation has continued through the fall 2023, spring 2024, and ongoing fall 2024 semesters, introducing improvements at every iteration, with adjustments made to the parallel projects and the identification of intervention points for self-transformation through analogy. The creators of the program will present the outcomes from the pilot implementations and address the obstacles and future work. This proposed endeavor is aligned with the continuous mission of the College of Engineering and Computer Science (CECS) at the University of X, which includes: 1) increasing the number of STEM degrees granted to Hispanics, 2) promoting the participation of women in STEM-related fields, and 3) enhancing persistence and self-confidence in STEM fields amidst the challenges posed by COVID-19. The project is supported by the NSF award 2225247