Sistema de Gestión del Conocimiento ANLIS MALBRÁN
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TRIO-related intellectual disability with microcephaly: a case report of a patient with novel clinical findings
No full textFil: Bevilacqua, Florencia. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica. Departamento de Diagnóstico Médico; Argentina.Fil: Alberto, Guillermo. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica. Departamento de Diagnóstico Médico; Argentina.Fil: Duarte, Santiago Pablo. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica. Departamento de Diagnóstico Médico; Argentina.Fil: Serra, Marina. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica. Departamento de Diagnóstico Médico; Argentina.Fil: Basterra, Julieta. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica. Departamento de Diagnóstico Médico; Argentina.Fil: Espeche, Lucía. Department of Clinical GeneticsFil: Cerretini, Roxana Inés. Department of Clinical GeneticsFil: Solari, Andrea Paula. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica. Departamento de Diagnóstico Médico; Argentina
Lonomia envenomation in Brazil: an epidemiological overview for the period 2007-2018
No full textFil: Melo Favalesso, Marília. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Medicina Tropical; Argentina.Fil: Cuervo, Pablo Fernando. Laboratorio de Ecología de Enfermedades, Instituto de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral/Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Casafús, Milena Gisela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Medicina Tropical; Argentina.Fil: Bittencourt Guimaraes, Ana Tereza. Laboratório de Investigações Biológicas, Universidade Estadual do Oeste do Paraná; Brasil.Fil: Peichoto, Maria Elisa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Medicina Tropical; Argentina.Among the Lepidoptera with medical importance in Brazil, larvae of Lonomia moth (Saturniidae: Hemileucinae) stand out by being the etiological agent of the lonomism, a form of erucism in which the most troubling symptoms include systemic hemorrhage that can lead to death
Living with the COVID-19 pandemic: act now with the tools we have
Full text linkFil: Bedford, Juliet. Anthrologica, Oxfordshire; Reino Unido.Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Giesecke, Johan. Karolinska Institute, Stockholm; Suecia.Fil: Heymann, David L. Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine; Reino Unido.Fil: Ihekweazu, Chikwe. Nigeria Centre for Disease Control; Nigeria.Fil: Kobinger, Gary. Infectious Disease Research Centre, Université Laval, Faculty of Medicine; Canada.Fil: Lane, H Clifford. National Institute of Allergy and Infectious Diseases; Estados Unidos.Fil: Memish, Ziad A. J W Lee Center for Global Medicine, SNU College of Medicine, Department of Internal Medicine, Seoul National University Hospital; Corea del Sur.Fil: Oh, Myoung-Don. J W Lee Center for Global Medicine, SNU College of Medicine, Department of Internal Medicine, Seoul National University Hospital; Corea del Sur.Fil: Sall, Amadou Alpha. Institut Pasteur de Dakar; Senegal.Fil: Ungchusak, Kumnuan. Ministry of Health, Department of Diseases Control; Tailandia.Fil: Wieler, Lothar H. Robert Koch Institute; Alemania.The responses of countries to the COVID-19 pandemic have been disparate.1, 2 Many countries are reopening workplaces, schools, and social gatherings and striving to adapt their economies and resume international travel. Other countries are attempting to suppress transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by again restricting businesses, industries, and schools while hoping for future COVID-19 vaccines or treatments. The Strategic and Technical Advisory Group for Infectious Hazards (STAG-IH), the independent advisory group to the WHO Health Emergencies Programme, has reviewed information from countries around the world and has concluded that the most sound approach on the basis of current understanding is to deploy long-term strategies with a focus on preventing amplification of transmission, protecting those most at risk of severe illness, and supporting research to better understand the virus, the disease, and people's responses to them
Critical aspects on traditional antivenom production processes and their optimization by factorial analysis
Full text linkFil: Zurbano, Beatriz N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Tavarone, Eugenia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Viacava, Belén González. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Dokmetjian, José C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Cascone, Osvaldo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Fingermann, Matías. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Most antivenoms are produced by techniques developed over 50 years ago, with minor modifications. Herein we revise the core of traditional antivenom production processes aiming to optimize key determinants for both consistent antivenom production and the best balance between F(ab')2 quality and recovery. Factorial design analysis revealed that pepsin digestion of 1:3 saline diluted equine plasma for 60 min under pH: 3.20, 37 °C temperature and a 1:15 pepsin to protein ratio conditions, allowed to achieve maximal IgG to F(ab')2 conversion with minimal protein aggregate formation. Further downstream processing by salting out with ammonium sulfate was also studied by factorial analysis. The influence of ammonium sulfate (AS) concentration, temperature (T) and the albumin to total plasma protein ratio plasma (Alb:P) were assayed, revealing that both AS, T and their interaction have a significant impact in F(ab')2 quality and recovery. Taking into account the existing compromise between F(ab')2 monomer recovery and quality two alternative conditions were selected: 14 g/dl AS at 56 °C and, alternatively 16 g/dl AS at 30 °C. Reasonable yields (42%) and product quality (2.5% of aggregates) without significant changes in production cost of traditional methodologies was achieved under the optimized conditions found
Critical aspects on traditional antivenom production processes and their optimization by factorial analysis
Full text linkFil: Zurbano, Beatriz N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Tavarone, Eugenia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Viacava, Belén González. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Dokmetjian, José C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Cascone, Osvaldo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Fingermann, Matías. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Most antivenoms are produced by techniques developed over 50 years ago, with minor modifications. Herein we revise the core of traditional antivenom production processes aiming to optimize key determinants for both consistent antivenom production and the best balance between F(ab')2 quality and recovery. Factorial design analysis revealed that pepsin digestion of 1:3 saline diluted equine plasma for 60 min under pH: 3.20, 37 °C temperature and a 1:15 pepsin to protein ratio conditions, allowed to achieve maximal IgG to F(ab')2 conversion with minimal protein aggregate formation. Further downstream processing by salting out with ammonium sulfate was also studied by factorial analysis. The influence of ammonium sulfate (AS) concentration, temperature (T) and the albumin to total plasma protein ratio plasma (Alb:P) were assayed, revealing that both AS, T and their interaction have a significant impact in F(ab')2 quality and recovery. Taking into account the existing compromise between F(ab')2 monomer recovery and quality two alternative conditions were selected: 14 g/dl AS at 56 °C and, alternatively 16 g/dl AS at 30 °C. Reasonable yields (42%) and product quality (2.5% of aggregates) without significant changes in production cost of traditional methodologies was achieved under the optimized conditions found
Distribution of PCV13 and PPSV23 Streptococcus pneumoniae serotypes in Argentinean adults with invasive disease, 2013-2017
No full textFil: Zintgraff, Jonathan. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Fossati, M. S. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Sorhouet Pereira, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Veliz, Omar. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Moscoloni, Maria Alicia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Irazu, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Lara, Claudia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Fil: Napoli, Daniela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. To identify the serotypes most commonly associated with infection in adults in Argentina, 791 pneumococcal isolates from 56 hospitals belonging to 16 provinces and Buenos Aires city were serotyped. The isolates were submitted as part of a National Surveillance Program for invasive pneumococcal disease in adults, which started in 2013. Serotypes 3, 8, 12F, 7F and 1 were the most prevalent among adult patients. During the study period there was no significant difference in serotype distribution between the age groups studied (18-64 and ≥65 years old), except for serotype 1, 3 and 23A. Most prevalent serotypes in pneumonia were serotype 7F, 1, 12F, 8, and 3. When the clinical diagnosis was meningitis, serotype 3 and 12F were the most prevalent, whereas when the diagnosis was sepsis/bacteremia the most prevalent was serotype 8. In this work, for the 18-64-year-old group, PPSV23 and PCV13 serotypes accounted for 74.56% and 44.54% respectively of the cases in the studied period. On the other hand, for the ≥65-year-old group, these serotypes represented 72.30% and 41.42% respectively. The aim of this work was to establish the knowledge bases of the serotypes that cause invasive pneumococcal diseases in the adult population in Argentina and to be able to detect changes in their distribution over time in order to explore the potential serotype coverage of the vaccines in current use
Phaeohyphomycosis by Exserohilum rostratum in a pediatric patient with acute lymphoblastic leukemia after bone marrow transplantation
No full textFil: Pena Amaya, Paula. Servicio de Microbiología, Hospital de Niños «Ricardo Gutiérrez», Ciudad Autónoma de Buenos Aires; Argentina.Fil: Flores, Antonio. Servicio de Microbiología, Hospital de Niños «Ricardo Gutiérrez», Ciudad Autónoma de Buenos Aires; Argentina.Fil: Christmann, Analía. Unidad de Transplante de Médula Ósea, Hospital de Niños «Ricardo Gutiérrez»; ArgentinaFil: Detoni, Débora. Unidad de Transplante de Médula Ósea, Hospital de Niños «Ricardo Gutiérrez»; ArgentinaFil: Drelichman, Guillermo. Unidad de Transplante de Médula Ósea, Hospital de Niños «Ricardo Gutiérrez»; ArgentinaFil: Soberón, Bárbara. Unidad de Transplante de Médula Ósea, Hospital de Niños «Ricardo Gutiérrez»; ArgentinaFil: Fernández Escobar, Nicolás. Unidad de Transplante de Médula Ósea, Hospital de Niños «Ricardo Gutiérrez»; ArgentinaFil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Vázquez, Miryam. Servicio de Microbiología, Hospital de Niños «Ricardo Gutiérrez», Ciudad Autónoma de Buenos Aires; Argentina.The genus Exserohilum consists of dematiaceous or darkly pigmented fungi. Most of the species included in this genus are phytopathogens, saprobes and only three of these species would be pathogenic to humans: Exserohilumrostratum, Exserohilumlongirostratum and Exserohilummcginnisii. Localized and systemic infections have been reported both in immunocompetent and immunosuppressed patients. A clinical case of cutaneous infection by E. rostratum in an immunocompromised pediatric patient is presented in this study.
Human respiratory syncytial virus and influenza seasonality patterns-Early findings from the WHO global respiratory syncytial virus surveillance
Full text linkHuman respiratory syncytial virus (RSV) causes illnesses among all age groups and presents a burden to healthcare services. To better understand the epidemiology and seasonality of RSV in different geographical areas, the World Health Organization (WHO) coordinated a pilot initiative to access the feasibility of establishing RSV surveillance using the existing Global Influenza Surveillance and Response System (GISRS) platform
