Hal - Université Grenoble Alpes
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Geodynamo Simulation Explorer: a filterable and visualisable catalogue to explore geodynamo simulations
No full textWe present a new web tool, Geodynamo Simulation Explorer, to survey available published simulations of rapidly rotating spherical dynamos.With numerical codes and computers being increasingly efficient, recent years have seen a surge in the number of publications presenting such computations.Our tool comes as an interactive catalogue that allows exploring existing dynamos with respect to input and output dimensionless parameters, choosing from various dynamo setups (e.g. choice of boundary conditions, couplings at play, etc.), with the possibility to test scaling laws on a filtered set of simulations. It also links each dynamo to its associated publication and possibly to online datasets.Thought of as a collaborative and scalable initiative, the web interface allows uploading new simulation metadata.The whole interface, displayed as a website, is designed for the community to have a better overview while driving transparency, open-source initiatives, and FAIR principles (Findable, Accessible, Interoperable, Reusable).Check it out and feed it at https://geodyn.univ-grenoble-alpes.fr/explorer/
An Enterprise Marketplace for Unified Access to Multi-Cloud and Enterprise Products in a Large Banking Infrastructure
No full textInternational audienceWe present the design and evaluation of an Enterprise Marketplace that unifies web-based access to multi-cloud and enterprise products within a large banking infrastructure. Building such a platform poses significant technical and organizational challenges, including the generalization of diverse APIs and the accommodation of heterogeneous user profiles. Our solution enables autonomous product publishing via a no-code interface, enforces multi-layered governance to ensure security and compliance, and integrates disparate providers through a standardized API. We demonstrate how this approach enhances product quality, producer autonomy, and user experience, supported by adoption metrics and operational data from a real-world deployment. Finally, we reflect on key lessons learned and persistent challenges after a decade of production use, serving over 200,000 users
Déclaration de nationalité française : l'article 21-12 du Code civil est d'interprétation stricte
No full textInternational audienc
Targeted Photodynamic Therapy for Pancreatic Cancer: Recent Innovations from Fundamentals to <i>In Vivo</i> and Clinical Applications (2020-2025)
No full textInternational audiencePhotodynamic Therapy (PDT) is a clinically-approved medical modality to treat different types of localised conditions such as cancer, infections or skin conditions. Pancreatic cancer (PC) is a deadly cancer displaying a dramatic overall prognosis that has barely improved in decades as the majority of PC patients are diagnosed at a locally advanced or metastatic stage and cannot benefit of surgical resection which is the only curative treatment, the overall 5-year survival rate remains extremely low. Thus, finding new therapies for non-metastatic PC to improve local control as a bridge to surgical resection and improve survival outcomes remains a huge challenge. In this context, PDT could be an interesting option. This review will focus on the use of PDT with targeted photosensitisers or nanoparticles to treat PC in recent studies (2020-2025) from in vitro to in vivo experiments and clinical applications
Site-specific attachment of a H2-evolving artificial metalloenzyme onto carbon nanotubes via electrografting of a protected thiophenolate diazonium salt
No full textInternational audienceThe development of efficient and stable electrodes for hydrogen evolution is a key challenge in the field of artificial enzymes and bioelectrocatalysis. We report the tuning of an artificial metalloenzyme–electrode interface using a covalent near-monolayered thiophenolate functionalisation of multiwalled carbon nanotubes (MWCNT). To this end, we synthesized, characterized, and electrografted 4-diazophenyl disulfide bis(tetrafluoroborate) to the surface of carbon-nanotube electrodes. A subsequent deprotection step yields highly functionalized thiophenolate-modified CNTs, which were employed for the immobilization of ferrocene derivatives and rubredoxins either via disulfide or thiolene formation. Introduction of a surface-accessible cysteine residue via site-directed mutagenesis of rubredoxin – followed by Fe-to-Ni metal substitution – affords the site-specific immobilization of this H2-evolving artificial metalloenzyme, which delivers up to 4 mA cm−2 at 800 mV overpotential
SIMILARITÉS ET DIFFÉRENCES RÉDACTIONNELLES EN LANGUE MATERNELLE ET EN LANGUE ÉTRANGÈRE CHEZ LES APPRENANTS RUSSOPHONES DE FLE
No full textInternational audienceCet article examine les textes argumentatifs produits par les mêmes participants dans deux langues : le russe, leur langue maternelle (LM), et le français langue étrangère (FLE), afin de mieux comprendre dans quelle mesure les stratégies rédactionnelles issues de la LM sont transférées en FLE. Les analyses révèlent des écarts en ce qui concerne la longueur et la complexité des différentes parties des textes en FLE. Les limitations d’ordre syntaxique et lexical freinent les apprenants dans la production de textes en français. Les questionnaires distribués aux participants permettent également d’éclairer certaines stratégies rédactionnelles ainsi que le degré de conscience qu’ont les apprenants de leurs pratiques d’écriture
Euclid preparation. Galaxy 2-point correlation function modelling in redshift space
No full textInternational audienceThe Euclid satellite will measure spectroscopic redshifts for tens of millions of emission-line galaxies. In the context of Stage-IV surveys, the 3-dimensional clustering of galaxies plays a key role in providing cosmological constraints. In this paper, we conduct a model comparison for the multipole moments of the galaxy 2-point correlation function (2PCF) in redshift space. We test state-of-the-art models, in particular the effective field theory of large-scale structure (EFT), one based on the velocity difference generating function (VDG), and different variants of Lagrangian perturbation theory (LPT) models, such as convolutional LPT (CLPT) and its effective-field-theory extension (CLEFT). We analyse the first three even multipoles of the 2PCF in the Flagship 1 simulation, which consists of four snapshots at . We study both template-fitting and full-shape approaches and find that with the template-fitting approach, only the VDG model is able to reach a minimum fitting scale of at without biasing the recovered parameters. Indeed, the EFT model becomes inaccurate already at . Conversely, in the full-shape analysis, the CLEFT and VDG models perform similarly well, but only the CLEFT model can reach while the VDG model is unbiased down to at the lowest redshift. Overall, in order to achieve the accuracy required by Euclid, non-perturbative modelling such as in the VDG or CLEFT models should be considered. At , the CLPT model is sufficient to describe the data with high figure of merit. This comparison selects baseline models that perform best in ideal conditions and sets the stage for an optimal analysis of Euclid data in configuration space
Field-induced states and thermodynamics of the frustrated Heisenberg antiferromagnet on a square lattice
No full textWe investigate the ground-state and finite-temperature properties of the - Heisenberg antiferromagnet on the square lattice in the presence of an external magnetic field. We focus on the highly frustrated regime around . The - phase diagram is investigated with particular emphasis on the finite-temperature transition into the "up-up-up-down" state that is stabilized by thermal and quantum fluctuations and manifests itself as a plateau at one half of the saturation magnetization in the quantum case. We also discuss the enhanced magnetocaloric effect associated to the ground-state degeneracy that arises at the saturation field for . For reference, we first study the classical case by classical Monte Carlo simulations. Then we turn to the extreme quantum limit of spin-1/2 where we perform zero- and finite-temperature Lanczos calculations
Microbial life in Arctic pack ice: Prospects for the Tara Polaris expeditions
No full textInternational audienceSea ice, unlike freshwater ice, hosts abundant microbial life, thanks to the presence of liquid water inclusions encased within the ice matrix. The forthcoming Tara Polaris Expeditions (TPE), which will document drifting Arctic pack ice repeatedly over multiple years, together offer an unprecedented opportunity to advance understanding of the sea-ice microbiome -its diversity, variations, and ecological roles. In this contribution, we consider the current state of knowledge, identify key research gaps, and outline the potential for progress enabled by TPE. We envision the emergence of new insights into the seasonal evolution of microbial life, resolved at the floe (kilometric) scale, in relation to the evolution of the sea-ice environment -its morphology, light, temperature, and liquid water distribution and properties. Large potential lies in the characterization of diverse microhabitats across the central Arctic Ocean, associated with brine inclusions, pressure ridge cavities, and melt ponds. A major goal will be to document biological processes that remain poorly understood -colonization, diversity, functioning, interactions, and evolutionary dynamics -and that could benefit from the application of newly developed techniques. We argue that TPE is particularly timely, as the loss of multi-year ice may soon constrain opportunities to study life in this rapidly changing habitat