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Enfermedad pulmonar grave asociada a cigarrillos electrónicos (EPCE)
No full textOs casos preséntanse con clínica inespecífica que pode ser de días ou semanas de evolución. A clínica consiste, nun 95% dos casos, en síntomas respiratorios (tose, dificultade respiratoria, dor torácica) e nun 77% presentan síntomas gastrointestinais como náuseas, vómitos ou dor abdominal. Nun 85% dos casos aos síntomas anteriores acompáñanlle síntomas sistémicos como febre ou perda de peso. O 95% dos pacientes requiriron hospitalización e unha porcentaxe elevada destes fixérono en Unidades de Coidados Intensivos e precisaron ventilación mecánica.Los casos se presentan con clínica inespecífica que puede ser de días o semanas de evolución. La clínica consiste, en un 95% de los casos, en síntomas respiratorios (tos, dificultad respiratoria, dolor torácico) y en un 77% presentan síntomas gastrointestinales como náuseas, vómitos o dolor abdominal. En un 85% de los caos a los síntomas anteriores le acompañan síntomas sistémicos como fiebre o pérdida de peso. El 95% de los pacientes requirieron hospitalización y un porcentaje elevado de éstos lo hicieron en Unidades de Cuidados Intensivos y precisaron ventilación mecánica
Prevalencia do consumo de alcohol e factores asociados ao consumo de risco en Galicia durante 2017
No full textLos resultados obtenidos en este trabajo muestran las importantes diferencias que hay en cuanto las prevalencias de consumo de alcohol a diario, de manera ocasional, de binge drinking y de consumo de riesgo en Galicia en hombres y mujeres. Las prevalencias globales de consumo siempre son más altas en los hombres. Las características diferenciales que se asocian a un consumo de riesgo son el nivel de estudios básicos y medios y la autopercepción del estado de salud como muy bueno o bueno/normal en los hombres. La vista de estos resultados es necesario desarrollar campañas de información y programas de salud dirigidos a concienciar, sobre todo a los chicos, de los efectos nocivos que produce el consumo de alcohol. Estos programas deben tener en cuenta las diferencias encontradas en el consumo en función del sexo, hacia orientar las intervenciones a los grupos poblacionales con prevalencias más altas. Asimismo, se debe potenciar la detección precoz del consumo de riesgo de alcohol en la población gallega y tener en cuenta en el diseño de los programas las diferencias encontradas nos consumidores de riesgo en función del sexo.Os resultados obtidos neste traballo mostran as importantes diferenzas que hai en canto as prevalencias de consumo de alcohol a diario, de xeito ocasional, de binge drinking e de consumo de risco en Galicia en homes e mulleres. As prevalencias globais de consumo sempre son máis altas nos homes. As características diferenciais que se asocian a un consumo de risco son o nivel de estudos básicos e medios e a autopercepción do estado de saúde como moi bo ou bo/normal nos homes. A vista destes resultados é necesario desenvolver campañas de información e programas de saúde dirixidos a concienciar, sobre todo aos mozos, dos efectos nocivos que produce o consumo de alcohol. Estes programas deben ter en conta as diferenzas atopadas no consumo en función do sexo, cara a orientar as intervencións aos grupos poboacionais con prevalencias máis altas. Así mesmo, débese potenciar a detección precoz do consumo de risco de alcol na poboación galega e ter en conta no deseño dos programas as diferencias atopadas nos consumidores de risco en función do sexo
Localizar una revista por título en Mergullador
No full textMergullador6Cómo localizar una revista buscando por el título en el nuevo Mergullado
Otros cambios recientes en el nuevo Pubmed
No full textPubMed6El vídeo explica el cambio de formato RIS por el formato Pubmed en la pción de guardar resultados en Pubmed, la opción de enviar a un gestor de citas, y la actualización de novedades sobre una estrategia por RSS
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
Get PDFThis study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 +/- 3.84 years and BMI 37.92 +/- 4.85 kg/m(2)) and 28 age-matched healthy lean (24.56 +/- 3.50 years and BMI of 22.10 +/- 1.72 kg/m(2)) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues
XPO1 Gene Therapy Attenuates Cardiac Dysfunction in Rats with Chronic Induced Myocardial Infarction
Get PDFTranscriptomic signature of XPO1 was highly expressed and inversely related to left ventricular function in ischemic cardiomyopathy patients. We hypothesized that treatment with AAV9-shXPO1 attenuates left ventricular dysfunction and remodeling in a myocardial infarction rat model. We induced myocardial infarction by coronary ligation in Sprague-Dawley rats (n = 10), which received AAV9-shXPO1 (n = 5) or placebo AAV9-scramble (n = 5) treatment. Serial echocardiographic assessment was performed throughout the study. After myocardial infarction, AAV9-shXPO1-treated rats showed partial recovery of left ventricular fractional shortening (16.8 +/- 2.8 vs 24.6 +/- 4.1%, P < 0.05) and a maintained left ventricular dimension (6.17 +/- 0.95 vs 4.70 +/- 0.93 mm, P < 0.05), which was not observed in non-treated rats. Furthermore, lower levels of EXP-1 (P < 0.05) and lower collagen fibers and fibrosis in cardiac tissue were observed. However, no differences were found in the IL-6 or TNFR1 plasma levels of the myocardium of AAV9-shXPO1 rats. AAV9-shXPO1 administration attenuates cardiac dysfunction and remodeling in rats after myocardial infarction, producing the gene silencing of XPO1
Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) sobre el tratamiento de pacientes con enfermedad inflamatoria intestinal asociada a espondiloartritis
Get PDFExtraintestinal manifestations, in general, and in particular arthropathies, are a common problem in patients with inflammatory bowel disease. In fact, the relationship between those 2entities is close and there are increasingly more data which suggest that the bowel plays a significant role in the aetiopathogenesis of spondyloarthritis. The association of inflammatory bowel disease with any kind of spondyloarthritis represents a challenging clinical scenario. It is therefore necessary that both gastroenterologists and rheumatologists work together and establish a fluent communication that enables the patient to receive the most appropriate treatment for each specific situation. The aim of this review is to make some recommendations about the treatment of patients with inflammatory bowel disease and associated spondyloarthritis, in each different clinical scenario
Cost-Effectiveness Analysis of Apixaban Versus Edoxaban in Patients with Atrial Fibrillation for Stroke Prevention
Get PDFOBJECTIVE: Our objective was to assess the cost effectiveness of apixaban versus edoxaban in the prevention of stroke and systemic embolism (SE) in patients with atrial fibrillation (AF) in Spain. METHODS: We customized a Markov model with ten health states to estimate the lifetime economic and clinical outcomes in 6-week cycles. The efficacy (clinical event rates per 100 patient-years) and safety data were derived from a pairwise indirect treatment comparison. The analysis was conducted from both the national health service (NHS) and societal perspectives, and included pharmaceutical costs (retail price plus value-added tax (VAT) and applicable national deductions) according to daily dosages (apixaban 10 mg (5 mg twice daily (bid)) and edoxaban 60 or 30 mg) and complications and disease-management costs, obtained from national databases. Utilities for quality-adjusted life-year (QALY) calculations reflected EuroQoL 5-Dimension scores in patients with AF. An annual discount rate of 3% was applied for costs (euro, year 2019 values) and outcomes. RESULTS: In a 1000-patient cohort, apixaban 5 mg bid versus edoxaban 60 mg could avoid five strokes, six major bleedings and 29 clinically relevant non-major bleedings (CRNMBs). Compared with edoxaban 30 mg, apixaban could avoid 21 strokes and two SEs. An increase in bleedings was observed with apixaban (seven haemorrhagic strokes, 48 major bleedings and 17 CRNMBs). Apixaban yielded 0.04 additional QALYs compared with edoxaban 60 mg or 30 mg. Incremental costs/QALY were euro9639.33 and euro354.22 for apixaban versus edoxaban 60 mg and edoxaban 30 mg, respectively, from the NHS perspective and euro7756.62 for apixaban versus edoxaban 60 mg from the societal perspective. Apixaban was dominant versus edoxaban 30 mg from the societal perspective. Sensitivity analyses confirmed the robustness of the model. CONCLUSIONS: This study suggests that apixaban 5 mg bid is a cost-effective alternative to edoxaban for stroke prevention in the AF population in Spain
Menigococcal endophthalmitis: A rare cause of endogenous endophthalmitis
Get PDFNeisseria meningitidis is a rare but severe cause of endogenous endophthalmitis. We report a case of a 46-year-old woman who presented an endophthalmitis secondary to an infection by Neisseria meningitidis that caused with meningitis. She was treated with corticosteroids and systemic and topical antimicrobials, but she presented loss of visual acuity as a consequence. We also review the cases reported in medical literature, and find out that 75.7 % of patients presented diverse complications. The prevalence of complications is higher in patients who received local treatment in combination with antibiotics. Patients who received corticosteroids as treatment presented a similar rate of complications than patients who did not