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Discovery Of Tev Gamma-Ray Emission Toward Supernova Remnant Snr G78.2+2.1
Get PDFWe report the discovery of an unidentified, extended source of very-high-energy gamma-ray emission, VER J2019+407, within the radio shell of the supernova remnant SNR G78.2+2.1, using 21.4 hr of data taken by the VERITAS gamma-ray observatory in 2009. These data confirm the preliminary indications of gamma-ray emission previously seen in a two-year (2007-2009) blind survey of the Cygnus region by VERITAS. VER J2019+407, which is detected at a post-trials significance of 7.5 standard deviations in the 2009 data, is localized to the northwestern rim of the remnant in a region of enhanced radio and X-ray emission. It has an intrinsic extent of and its spectrum is well-characterized by a differential power law (dN/dE = N 0 × (E/TeV)–Γ) with a photon index of Γ = 2.37 ± 0.14stat ± 0.20sys and a flux normalization of N 0 = 1.5 ± 0.2stat ± 0.4sys × 10–12 photon TeV–1 cm–2 s–1. This yields an integral flux of 5.2 ± 0.8stat ± 1.4sys × 10–12 photon cm–2 s–1 above 320 GeV, corresponding to 3.7% of the Crab Nebula flux. We consider the relationship of the TeV gamma-ray emission with the GeV gamma-ray emission seen from SNR G78.2+2.1 as well as that seen from a nearby cocoon of freshly accelerated cosmic rays. Multiple scenarios are considered as possible origins for the TeV gamma-ray emission, including hadronic particle acceleration at the SNR shock
Variability Of The Blazar 4C 38.41 (B3 1633+382) From Ghz Frequencies To Gev Energies
Get PDFContext. After years of modest optical activity, the quasar-type blazar 4C 38.41 (B3 1633+382) experienced a large outburst in 2011, which was detected throughout the entire electromagnetic spectrum, renewing interest in this source.
Aims. We present the results of low-energy multifrequency monitoring by the GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT) consortium and collaborators, as well as those of spectropolarimetric/spectrophotometric monitoring at the Steward Observatory. We also analyse high-energy observations of the Swift and Fermi satellites. This combined study aims to provide insights into the source broad-band emission and variability properties.
Methods. We assemble optical, near-infrared, millimetre, and radio light curves and investigate their features and correlations. In the optical, we also analyse the spectroscopic and polarimetric properties of the source. We then compare the low-energy emission behaviour with that at high energies.
Results. In the optical-UV band, several results indicate that there is a contribution from a quasi-stellar-object (QSO) like emission component, in addition to both variable and polarised jet emission. In the optical, the source is redder-when-brighter, at least for R ≳ 16. The optical spectra display broad emission lines, whose flux is constant in time. The observed degree of polarisation increases with flux and is higher in the red than the blue. The spectral energy distribution reveals a bump peaking around the U band. The unpolarised emission component is likely thermal radiation from the accretion disc that dilutes the jet polarisation. We estimate its brightness to be RQSO ~ 17.85–18 and derive the intrinsic jet polarisation degree. We find no clear correlation between the optical and radio light curves, while the correlation between the optical and γ-ray flux apparently fades in time, likely because of an increasing optical to γ-ray flux ratio.
Conclusions. As suggested for other blazars, the long-term variability of 4C 38.41 can be interpreted in terms of an inhomogeneous bent jet, where different emitting regions can change their alignment with respect to the line of sight, leading to variations in the Doppler factor δ. Under the hypothesis that in the period 2008–2011 all the γ-ray and optical variability on a one-week timescale were due to changes in δ, this would range between ~7 and ~21. If the variability were caused by changes in the viewing angle θ only, then θ would go from ~2.6° to ~5°. Variations in the viewing angle would also account for the dependence of the polarisation degree on the source brightness in the framework of a shock-in-jet model
The 2010 Very High Energy Gamma-Ray Flare And 10 Years Of Multi-Wavelength Observations Of M 87
Get PDFThe giant radio galaxy M 87 with its proximity (16 Mpc), famous jet, and very massive black hole ((3 – 6) × 109 M ☉) provides a unique opportunity to investigate the origin of very high energy (VHE; E \u3e 100 GeV) γ-ray emission generated in relativistic outflows and the surroundings of supermassive black holes. M 87 has been established as a VHE γ-ray emitter since 2006. The VHE γ-ray emission displays strong variability on timescales as short as a day. In this paper, results from a joint VHE monitoring campaign on M 87 by the MAGIC and VERITAS instruments in 2010 are reported. During the campaign, a flare at VHE was detected triggering further observations at VHE (H.E.S.S.), X-rays (Chandra), and radio (43 GHz Very Long Baseline Array, VLBA). The excellent sampling of the VHE γ-ray light curve enables one to derive a precise temporal characterization of the flare: the single, isolated flare is well described by a two-sided exponential function with significantly different flux rise and decay times of τrise d = (1.69 ± 0.30) days and τdecay d = (0.611 ± 0.080) days, respectively. While the overall variability pattern of the 2010 flare appears somewhat different from that of previous VHE flares in 2005 and 2008, they share very similar timescales (~day), peak fluxes (Φ\u3e0.35 TeV sime (1-3) × 10–11 photons cm–2 s–1), and VHE spectra. VLBA radio observations of 43 GHz of the inner jet regions indicate no enhanced flux in 2010 in contrast to observations in 2008, where an increase of the radio flux of the innermost core regions coincided with a VHE flare. On the other hand, Chandra X-ray observations taken ~3 days after the peak of the VHE γ-ray emission reveal an enhanced flux from the core (flux increased by factor ~2; variability timescale \u3c2 days). The long-term (2001-2010) multi-wavelength (MWL) light curve of M 87, spanning from radio to VHE and including data from Hubble Space Telescope, Liverpool Telescope, Very Large Array, and European VLBI Network, is used to further investigate the origin of the VHE γ-ray emission. No unique, common MWL signature of the three VHE flares has been identified. In the outer kiloparsec jet region, in particular in HST-1, no enhanced MWL activity was detected in 2008 and 2010, disfavoring it as the origin of the VHE flares during these years. Shortly after two of the three flares (2008 and 2010), the X-ray core was observed to be at a higher flux level than its characteristic range (determined from more than 60 monitoring observations: 2002-2009). In 2005, the strong flux dominance of HST-1 could have suppressed the detection of such a feature. Published models for VHE γ-ray emission from M 87 are reviewed in the light of the new data
Bacteriophages phi MR299-2 and phi NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells
Get PDFPseudomonas aeruginosa is a common cause of infection in the lungs of patients with cystic fibrosis (CF). In addition, biofilm formation and antibiotic resistance of Pseudomonas are major problems that can complicate antibiotic therapy. We evaluated the efficacy of using bacteriophages to kill the pathogen in both biofilms and in the murine lung. We isolated and characterized two phages from a local wastewater treatment plant, a myovirus (ϕNH-4) and a podovirus (ϕMR299-2). Both phages were active against clinical isolates of P. aeruginosa. Together, the two phages killed all 9 clinical isolate strains tested, including both mucoid and nonmucoid strains. An equal mixture of the two phages was effective in killing P. aeruginosa NH57388A (mucoid) and P. aeruginosa MR299 (nonmucoid) strains when growing as a biofilm on a cystic fibrosis bronchial epithelial CFBE41o- cell line. Phage titers increased almost 100-fold over a 24-h period, confirming replication of the phage. Furthermore, the phage mix was also effective in killing the pathogen in murine lungs containing 1 × 107 to 2 × 107 P. aeruginosa. Pseudomonas was effectively cleared (reduced by a magnitude of at least 3 to 4 log units) from murine lungs in 6 h. Our study demonstrates the efficacy of these two phages in killing clinical Pseudomonas isolates in the murine lung or as a biofilm on a pulmonary cell line and supports the growing interest in using phage therapy for the control and treatment of multidrug-resistant Pseudomonas lung infections in CF patients.
IMPORTANCE Given the rise in antibiotic resistance, nonantibiotic therapies are required for the treatment of infection. This is particularly true for the treatment of Pseudomonas infection in patients with cystic fibrosis. We have identified two bacterial viruses (bacteriophages) that can kill Pseudomonas growing on human lung cells and in an animal model of lung infection. The use of bacteriophages is particularly appropriate because the killing agent can replicate on the target cell, generating fresh copies of the bacteriophage. Thus, in the presence of a target, the killing agent multiplies. By using two bacteriophages we can reduce the risk of resistant colonies developing at the site of infection. Bacteriophage therapy is an exciting field, and this study represents an important demonstration of efficacy in validated infection models
Investigating the Spectrum of Biological Activity of Substituted Quinoline-2-Carboxamides and Their Isosteres
Get PDFIn this study, a series of thirty-five substituted quinoline-2-carboxamides and thirty-three substituted naphthalene-2-carboxamides were prepared and characterized. They were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial species. N-Cycloheptylquinoline-2-carboxamide, N-cyclohexylquinoline-2-carboxamide and N-(2-phenylethyl)quinoline-2-carboxamide showed higher activity against M. tuberculosis than the standards isoniazid or pyrazinamide and 2-(pyrrolidin-1-ylcarbonyl)quinoline and 1-(2-naphthoyl)pyrrolidine expressed higher activity against M. kansasii and M. avium paratuberculosis than the standards isoniazid or pyrazinamide. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The PET-inhibiting activity expressed by IC50 value of the most active compound N-benzyl-2-naphthamide was 7.5 μmol/L. For all compounds, the structure-activity relationships are discussed
Is Organisational Commitment Culturally Bound?
Get PDFThe paper investigates whether organisational commitment is culturally bound. Literature was reviewed on the impact of Hofstede’s four dimensions of culture on organisational commitment. Three hypotheses were put forward in relation to the cultural impact on the three components of organisational commitment: affective, normative and continuance commitment. Data was collected from two branches of an American multinational corporation with operations in China and Ireland. The two cultures were chosen as they demonstrate differences as well as similarities on Hofstede’s dimensions, which provided an opportunity to explore the cultural impact. The results supported two of the hypotheses that Chinese employees have higher levels of affective and normative commitment than their Irish counterparts. Such findings reaffirm some extant literature and justified the conclusion that affective and normative commitments are culturally bound. If organisational commitment is culturally bound then it is sufficient to use Hofstede’s cultural scores to compare organisational commitment across cultures. In addition, income was found to be significant in predicting continuance and normative commitment; tenure was a significant factor in understanding affective and normative commitment
Dark tourism: An assessment of the motivations of visitors to Auschwitz – Birkenau, Poland
Get PDFTravel to sites of death and destruction is not a new concept. It is however, a phenomenon that has in recent years emerged as a clearly identifiable tourism product from a supply perspective and a growing tourism trend throughout the world. An element of human nature is this fascination with death and disaster, which has been catered for through the emergence of tourism sites associated with death, disaster and destruction. Today, many places of death and disaster attract millions of tourists from around the world such as Auschwitz-Birkenau in Poland, Anne Frank’s House in Amsterdam, Ground Zero in New York, Arlington National Cemetery and the Apartheid Museum in Johannesburg, South Africa to name but a few. This paper seeks to establish an understanding of the concept of dark tourism and its growth throughout the world. It will then assess the role of dark tourism in a Polish context with a particular emphasis on Auschwitz – Birkenau (a German World War 2 concentration camp). The empirical research for this paper seeks to develop a profile of visitors to Auschwitz and examine the key motivations of visitors. A triangulation approach was adopted incorporating qualitative focus groups and a questionnaire survey in order to identify the motivations of visitors to this site. It emerged that education, curiosity and remembrance were the dominant motivations of visitors while almost all expressed the emotional impact of the visit
Proteins: form and function
Get PDFAn overwhelming array of structural variants has evolved from a comparatively small number of protein structural domains; which has in turn facilitated an expanse of functional derivatives. Herein, I review the primary mechanisms which have contributed to the vastness of our existing, and expanding, protein repertoires. Protein function prediction strategies, both sequence and structure based, are also discussed and their associated strengths and weaknesses assessed
Molecular diagnostics: the changing culture of medical microbiology
Get PDFDiagnostic molecular biology is arguably the fastest growing area in current laboratory-based medicine. Growth of the so called ‘omics’ technologies has, over the last decade, led to a gradual migration away from the ‘one test, one pathogen’ paradigm, toward multiplex approaches to infectious disease diagnosis, which have led to significant improvements in clinical diagnostics and ultimately improved patient care
Fair Trade, Marketing and Consumer Behaviour
Get PDFThis paper examines different aspects of fair trade marketing. Firstly, secondary research examines the development, advantages and challenges of fair trade. Secondly, primary research explores consumer buying behaviour in Ireland and Austria in the fast moving consumer goods (FMCGs) market. Thirdly, the attitudes of consumers towards mainstreaming and clean-washing are explored. Phase one of the data collection involved one hundred and twenty consumer surveys. In phase two exploratory research using mixed modes collected data from nine suppliers of fair trade FMCGs. The findings suggest that the effects of mainstreaming are perceived to be predominantly positive. The research findings also suggest that more needs to be done to manage consumer perceptions of fair trade. Specifically, consumers need to be convinced that their purchasing behaviour can actually make a difference. This paper will be of interest to marketing professionals and stakeholders in the fair trade and the FMCG sector in relation to: merchandising strategy for fair trade products; developing tailored brand communications for fair trade; and new fair trade product developmen