359 research outputs found
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An Explorative Case-Study of the use of PeerWise to Foster Student Centred, and Peer Supported, Learning in a First-Year Business Module
Full text linkPeer based learning is not a new concept in business studies in higher education; however, the integration of technology enabled and asynchronous peer learning has limited reported use and even less evidence based evaluation. In this explorative case study, the online tool PeerWise was used to scaffold and support an asynchronous peer-learning environment for a group of 212 first year business studies students. Students were required to create, answer and rate multiple choice questions on topics aligned to their curriculum within the peer constructed PeerWise question database. While there was no statistically significant correlation between PeerWise engagement and final module exam performance, conversely, considerable positive changes in student motivation, self-understanding and reflective learning were observed, informed by thematic analysis. With these key findings in mind, a set of themed recommendations for practice are offered to support staff seeking to integrate PeerWise, or technology enhanced peer learning more generally, into their teaching and learning practice
Simplicity DiffExpress: A Bespoke Cloud-Based Interface for RNA-seq Differential Expression Modeling and Analysis
Full text linkOne of the key challenges for transcriptomics-based research is not only the processing of large data but also modeling the complexity of features that are sources of variation across samples, which is required for an accurate statistical analysis. Therefore, our goal is to foster access for wet lab researchers to bioinformatics tools, in order to enhance their ability to explore biological aspects and validate hypotheses with robust analysis. In this context, user-friendly interfaces can enable researchers to apply computational biology methods without requiring bioinformatics expertise. Such bespoke platforms can improve the quality of the findings by allowing the researcher to freely explore the data and test a new hypothesis with independence. Simplicity DiffExpress is a data-driven software platform dedicated to enabling non-bioinformaticians to take ownership of the differential expression analysis (DEA) step in a transcriptomics experiment while presenting the results in a comprehensible layout, which supports an efficient results exploration, information storage, and reproducibility. Simplicity DiffExpress’ key component is the bespoke statistical model validation that guides the user through any necessary alteration in the dataset or model, tackling the challenges behind complex data analysis. The software utilizes edgeR, and it is implemented as part of the SimplicityTM platform, providing a dynamic interface, with well-organized results that are easy to navigate and are shareable. Computational biologists and bioinformaticians can also benefit from its use since the data validation is more informative than the usual DEA resources. Wet-lab collaborators can benefit from receiving their results in an organized interface. Simplicity DiffExpress is freely available for academic use, and it is cloud-based (https://simplicity.nsilico.com/dea)
Hybrid external cavity laser with an amorphous silicon-based photonic crystal cavity mirror
Full text linkThe authors present results on the performance of a hybrid external cavity photonic crystal laser-comprising semiconductor optical amplifier, and a 2D photonic crystal cavity fabricated in low-temperature amorphous silicon. The authors demonstrate that lithographic control over amorphous silicon photonic crystal cavity-resonant wavelengths is possible, and that single-mode lasing at optical telecommunications wavelengths is possible on an amorphous silicon platform
Liver fluke in Irish sheep: prevalence and associations with management practices and co-infection with rumen fluke
Full text linkBackground
The present study aimed to identify the national prevalence of Fasciola hepatica in Irish sheep and to conduct a risk analysis assessment based on management and treatment practices in participating flocks. Also, co-infection with rumen fluke was quantified and its association with liver fluke and management practices was assessed.
Methods
A total of 305 sheep flocks were selected ensuring even national representation of the sheep population. Participating farms were asked to complete a survey questionnaire on farm management practices and submit faecal samples during the winter of 2014–2015. Pooled faecal samples were analysed for the presence of F. hepatica and co-infection with rumen fluke. Apparent and true prevalence were calculated, additionally, the rate of co-infection with rumen fluke was also obtained. Correlation and regression analyses were used for assessing associations between management practices, liver fluke infection and co-infection with rumen fluke.
Results
The national true prevalence of F. hepatica was 50.4% (n = 305). Regional prevalence varied from 41% in the east to 52% in the south. Co-infection with rumen fluke was observed in 40% of the studied population and correlated with increased F. hepatica egg counts (OR = 2.9; P ≤ 0.001). Predominant breeds were Suffolk, Texel and Horned Mountain breeds. Beef cattle were the most frequent type of other livestock present on farms and mixed species grazing was frequently reported (73%). More than half of the flocks reported a mid-to-late lambing period (March-April). Use of mountain land for grazing was of 32%. Flukicides were most commonly used twice over the autumn-winter period. Regression analyses highlighted significant association of F. hepatica status, with the presence of other livestock on farm, frequency of flukicides used during the winter and clinical presentation of liver fluke. A significant increase in eggs per gram of faeces was observed in Charollais sheep in comparison with all other breeds. Co-infection with F. hepatica and Calicophoron daubneyi was also significantly associated with the presence of other livestock on the farm, type of flukicide used and clinical fasciolosis.
Conclusions
The present study provides up-to-date information on the prevalence of F. hepatica in Irish sheep and adds insight to the epidemiology of the disease. These findings will be useful for designing new holistic control measures for F. hepatica infection
A Bridge Rehabilitation Strategy Based on the Analysis of a Dataset of Bridge Inspections in Co. Cork
Full text linkAgeing highway structures present a challenge throughout the developed world. The introduction of bridge management systems (BMS) allows bridge owners to assess the condition of their bridge stock and formulate bridge rehabilitation strategies under the constraints of limited budgets and resources. This research presents a decision-support system for bridge owners in the selection of the best strategy for bridge rehabilitation on a highway network. The basis of the research is an available dataset of 1,367 bridge inspection records for County Cork that has been prepared to the Eirspan BMS inspection standard and which includes bridge structure condition ratings and rehabilitation costs. There has been no previous research on a regional Irish bridge stock of this magnitude. Research objectives are the consolidation of the dataset into a usable format, the review of previous research and the formulation of a methodology for the development of a network wide bridge rehabilitation strategy model. A procedure proposed by previous research on the prioritisation of theoretical bridge rehabilitation projects on the Chilean road network has been built upon. Statistical analysis of both recent rehabilitation projects in County Cork and of a survey of experts has led to the formulation of rehabilitation project prioritisation indices. The application of these derived indices allows the forecasting and calculation of funding requirements for network wide improvements. A review of the functional life expectancies of bridges has been undertaken. A deterioration rate which predicts the annual disimprovement in condition rating of each bridge has been calculated using statistical regression analysis and provides a basis for the estimation of investment requirements for an overarching rehabilitation strategy. An economic assessment of four rehabilitation intervention strategies has been undertaken using the Net Present Worth method. A system performance method developed in this research and which uses efficiency and effectiveness indicators taken from UK, New Zealand and French practice has determined that the range of annual investment amounts equivalent to 0.27% and 1% respectively of the bridge stock replacement cost are required to achieve full bridge network rehabilitation and provide a minimum 85 year service life for all structures. A benchmarking comparison with reported international practice has confirmed the applicability of the developed methodology
‘A Healthy CIT’: An Investigation into Student Health Metrics, Lifestyle Behaviours and the Predictors of Positive Mental Health in an Irish Higher Education Setting
Full text linkHigher Education Institutions (HEIs) are potent health promotion settings, uniquely positioned to aid societal efforts to combat non-communicable diseases (NCDs). International evidence suggests that health metrics and lifestyle behaviours of higher education students are sub-optimal, yet a dearth of contemporary Irish data exists. This study aimed to examine sex differences in student lifestyle behaviours and identify significant predictors of positive mental health in an Irish HEI setting. An online questionnaire instrument distributed to all registered students (n = 11,261) gathered data regarding a multitude of health and lifestyle domains. Many items were adapted from previous Irish research. Further validated scales included the Alcohol Use Disorders Identification Test (AUDIT), Mental-Health Index 5 (MHI-5) and the Energy and Vitality Index (EVI). Self-reported height/body mass were also recorded. In total, 2267 responses were analysed (51.7% female, 48.3% male). Both sexes demonstrated poor sleeping patterns, hazardous drinking and sub-optimal fruit and vegetable intake. The calculated prevalence of overweight/obesity was 38.2%. Both sexes underestimated obesity. Males underestimated and females overestimated overweight. Males displayed riskier behavioural patterns with regard to illicit substances, drinking, and sexual partners. Females reported greater psychological distress. Multivariate linear regression identified 8 variables as predictors of positive mental health, accounting for 37% of the variance in EVI scores. In conclusion, HEI students would benefit from sex-specific multi-level health promotion initiatives to remove macro-level barriers to healthier lifestyles
A Rapid Viability and Drug‑Susceptibility Assay Utilizing Mycobacteriophage as an Indicator of Drug Susceptibilities of Anti‑TB Drugs against Mycobacterium smegmatis mc2 155
Full text linkBackground: A rapid in-house TM4 mycobacteriophage-based assay, to identify multidrug resistance against various anti-tuberculosis drugs, using the fast-growing Mycobacterium smegmatis mc2 155 in a microtiter plate format was evaluated, based on phage viability assays. Methods: A variety of parameters were optimized before the study including the minimum incubation time for the drugs, phage and M. smegmatis mc2 155 to be in contact. An increase in phage numbers over 2 h was indicative that M. smegmatis mc2 155 is resistant to the drugs under investigation, however when phage numbers remained static, M. smegmatis mc2 155 found to be sensitive to the drug. Results: The study confirmed that the data are statistically significant and that M. smegmatis mc2 155 is, in fact, sensitive to isonazid, iifampicin, pyranzaimide, and ethambutol as phage numbers doubled over 2 h (P = 0.015, 0.018, 0.014, and 0.020). The study also confirmed that M. smegmatis mc2 155 is resistant to the drugs ampicillin, erythromycin, amoxicillin streptomycin as phage numbers remain static over the same 2 h period (P = 0.028, 0.052, 0.049, and 0.04). This drug-susceptibility profiling of eight different drugs against M. smegmatis mc2 155 was detected in as little as 1½ days with a cost of ~ one euro and fifteen cent to test four drugs. Conclusion: This test is rapid to perform and will have widespread applications in drug-susceptibility testing of other members of the mycobacterial genus. In addition, the platform could also be used as a tool for high-throughput screening of novel antimycobacterial drugs. The main assets of this assay include its relatively cheap cost, versatility, and quick turnaround time
Frequency modulated hybrid photonic crystal laser by thermal tuning
Full text linkWe demonstrate frequency modulation (FM) in an external cavity (EC) III-V/silicon laser, comprising a reflective semiconductor optical amplifier (RSOA) and a silicon nitride (SiN) waveguide vertically coupled to a 2D silicon photonic crystal (PhC) cavity. The PhC cavity acts as a tunable narrowband reflector giving wavelength selectivity. The FM was achieved by thermo-optical modulation of the reflector via a p-n junction. Single-mode operation was ensured by the short cavity length, overlapping only one longitudinal laser mode with the reflector. We investigate the effect of reflector modulation theoretically and experimentally and predict a substantial tracking of the resonator by the laser frequency with very small intensity modulation (IM)
Malnutrition in the elderly
Full text linkChanges that occur naturally throughout the ageing process place the elderly population at greater risk of malnourishment. This review discusses the significance, causes, consequences and assessment of malnutrition in the elderly
Slow light with interleaved p-n junction to enhance performance of integrated Mach-Zehnder silicon modulators
Full text linkSlow light is a very important concept in nanophotonics, especially in the context of photonic crystals. In this work, we apply our previous design of band-edge slow light in silicon waveguide gratings [M. Passoni et al, Opt. Express 26, 8470 (2018)] to Mach-Zehnder modulators based on the plasma dispersion effect. The key idea is to employ an interleaved p-n junction with the same periodicity as the grating, in order to achieve optimal matching between the electromagnetic field profile and the depletion regions of the p-n junction. The resulting modulation efficiency is strongly improved as compared to common modulators based on normal rib waveguides, even in a bandwidth of 20–30 nm near the band edge, while the total insertion loss due to free carriers is not increased. The present concept is promising in view of realizing slow-light modulators for silicon photonics with reduced energy dissipation