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SF3A1 Gene Polymorphism Affects Clinical Features, but not Susceptibility to Myelodysplastic Syndromes
No full textJournal ArticleBackground and aims: Recently, genome-wide analyses have revealed mutations in spliceosome machinery associated with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Single-nucleotide polymorphisms (SNPs) of serine/arginine-rich splicing factor 2 (SRSF2) and splicing factor 3a subunit 1 (SF3A1) were investigated in a Japanese population of patients and healthy control group. We aimed to find associations with prognosis and pathology.
Methods: We obtained genomic DNA from 99 patients with MDS, 92 patients with AML, and 172 healthy controls and detected SRSF2 (rs237057) and SF3A1 (rs2074733) genotypes using polymerase chain reaction–restriction fragment length polymorphism.
Results: There was no statistical significance to associate these polymorphisms with susceptibility to MDS/AML. However, the SF3A1 rs2074733 TC was significantly associated with higher hemoglobin level, compared to the TT genotype (mean±standard deviation, 10.6±1.63 vs 9.09±2.19 g/dL; P＝0.022). In addition, patients with rs2074733 TC showed a significantly lower frequency of chromosomal abnormality [2 (18.2%) vs. 46 (53.5%), P＝0.027]. We observed no statistical significance between these polymorphisms and clinical variables for AML, or the prognosis of MDS and AML.
Conclusions: Our study indicates that the SF3A1 rs2074733 TC genotype is associated with some clinical features of MDS.journal articl
DEAとInverted DEAのノンパラメトリック検定を用いた JR 本州3社とJR3島会社の事業活動効率に対する大手私鉄との比較検証
Get PDFDepartmental Bulletin PaperThis study evaluates the relative efficiencies of Japan Railway companies (hereinafter“JRs” and Japan's major private railway companies (hereinafter“Private Railways”), using various types of DEA (Data Envelopment Analysis). As the ninth report , this paper verifies the effects on the privatization and separation of JNR ( Japan National Railways) to the relative efficiency and inefficiency of JRs and Private Railways by using the parametric and nonparametric test of DEA and Inverted DEA (Inverted Data Envelopment Analysis). More specifically, in this paper, the first step of the evaluation of the relative efficiencies and inefficiencies to the productivity and others of each JR and Private Railways for a total of 19 years after the privatization and separation of JNR by using DEA and Inverted DEA. The second step of the verification of the effects on the privatization and separation of JNR to the productivity and others of the JR's Honshu 3-companies (East Japan Railway, Central Japan Railway and West Japan Railway) and Private Railways by using the parametric and nonparametric test of DEA and Inverted DEA are clarified. The third step of the verification of the effects on the privatization and separation of JNR to the productivity and others of the JR's 3-islands companies (Hokkaido Railway, Shikoku Railway and Kyushu Railway) and Private Railways, by using the parametric and nonparametric test of DEA and Inverted DEA are clarified. The verification of the effects on the privatization and separation of JNR of the productivity and others of the JR's Honshu 3-companies and the JR's 3-islands companies were identified statistically.departmental bulletin pape
図画工作科における児童の「つまずき」について ―児童へのアンケート調査から―
No full textDepartmental Bulletin Paperdepartmental bulletin pape
教職大学院における学修を促進する要因の検討 ―12年間の実践と成果検証を踏まえて―
No full textDepartmental Bulletin Paperdepartmental bulletin pape
Grip force control during object manipulation in cervical myelopathy
No full text群馬大学博士（保健学）Thesis or Dissertation学位記番号：保博甲138thesi
日本語史における平成時代の音韻変化
No full textDepartmental Bulletin PaperPhonological system of a particular language could change in thirty years of one generation. The Japanese language has undergone phonological evolution of its consonant system and prosodic system in these thirty years of the Heisei period: the distinctive feature of voiced plosives has changed from voicing to tenseness; the prosodic unit is changing from mora to syllable; the culminative function has predominated the distinctive function of word accent. These phonological changes are reflected on several cases of phonetic change among Japanese speakers of the Heisei generation.departmental bulletin pape
Social Justice in and through Mathematics Education: For Improving the Quality of Mathematics Teaching and Internalising Students’ Character Building
No full textDepartmental Bulletin PaperAside from being one of the systematically arranged disciplines, mathematics is also a social construction that views humans as active subjects in building knowledge through interaction with the surrounding environment. Therefore, in addition to being a medium to enhance students’ understanding of mathematical concepts, mathematics education should also apply the principles of social activity while linking mathematical concepts to social issues. This research is intended to reform mathematics learning so that it does not merely focus on students’ understanding of mathematical concepts, but also improve their quality through the application of ‘social justice in mathematics education’, while at the same time internalising issues related to social justice through the application of ‘social justice through mathematics education’ concepts. This study used action research as the research methodology considering its actionbased themes and characteristics, where the teacher performed and simultaneously reflected learning activities. The findings obtained from this study are: (i) several challenges related to the application of ‘social justice in and through mathematics education’ in mathematics learning area, among others, include the difficulty of changing the teacher’s mindset on how to teach mathematics to students equitably (socially) and how to foster teacher sensitivity in designing mathematics learning that integrated justice issues into mathematics learning; (ii) the implementation of the principle of ‘social justice in and through mathematics education’ in order to improve the quality of mathematics learning is felt to be ineffective because of the teacher’s ability to design and implement mathematics learning involving ‘social justice in mathematics learning’ and ‘social justice through mathematics learning’ remains adequate; and (iii) the application of ‘social justice in and through mathematics education’ has a significant effect on student involvement in mathematics learning. It is characterized by more active students in learning and more enthusiastic students in learning activities, because the material that is discussed very closely with students’ daily experiences. Furthermore, the findings of this study are expected to contribute to the reform of mathematics education, especially those related to productive mathematics learning, the planting of effective mathematical concepts in students, equitable mathematics learning, and simultaneously internalizing social justice issues through the application of concepts, such as building students’ character. By using the elements in the planning and reflection of lessons, teachers are able to develop a comprehensive guide for improving the quality of their lessons and at the same time internalize students’ character building by using social justice issues.departmental bulletin pape