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Efficient Few-Cycle Pulse Amplification Using an Optical Parametric Multi-Pass Cell Amplifier
No full textOptical generation of quasistationary plasma electromagnetic structures for particle collimation with petawatt picosecond lasers
No full textEvaluation of motion mitigation strategies for carbon ion therapy of abdominal tumors based on non-periodic imaging data
No full textObjective.To identify suitable combination strategies for treatment planning and beam delivery in scanned carbon ion therapy of moving tumors.Approach. Carbon ion treatment plans for five abdominal tumors were optimized on four-dimensional (4D) computed tomography (CT) data using the following approaches. 4DITV across all phases and within a gating window, single phase uniform dose, and an innovative 4D tracking internal target volume (ITV) strategy. Delivered single-fraction doses were calculated on time-resolved virtual CT images reconstructed from 2D cine-magnetic resonance imaging series, using a deformable image registration pipeline. Treatment plans were combined with various beam delivery techniques: three-dimensional (no motion mitigation), rescanning, gating, beam tracking, and multi-phase 4D delivery with and without residual tracking (MP4D and MP4DRT) to form in total 11 treatment modalities. Single fraction doses were accumulated to simulate a fractionated treatment.Main results. Breath-sampled treatments using the MP4D and MP4DRT delivery techniques were the only to achieveD95> 95% for hypofractionated treatments, with little dependence on the number of fractions. A combination of MP4DRT with the new 4D tracking ITV approach resulting in conformal dose distributions and demonstrated the greatest robustness against irregular motion and anatomical changes.Significance. This study demonstrates, that real-time adaptive beam delivery strategies can deliver conformal doses within single fractions, thereby enabling hypofractionated treatment schemes that are not feasible with conventional strategies
decaysim - A particle decay time simulator for the investigation of the spectral add up method
No full textA particle decay time simulator for the investigation of the spectral add up metho
Quantification of the low- pion excess in heavy-ion collisions at the LHC and top RHIC energy
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