638 research outputs found
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Socrates, the philosopher in the Theaetetus digression (172c-177c), and the ideal of homoiôsis theôi
No full text© 2011 Walter de Gruyter. Traditionally, scholars have taken homoiôsis theôi in the Theaetetus digression (172c-177c) to require neglect of particulars, but they have noted that although Socrates advocates it, he does not live such a life. To explain the discrepancy, Mahoney and Rue both argue that we need to reinterpret godlikeness to require active engagement in the city. I reject their reinterpretations and I revise the traditional view, arguing that godlikeness is not a single ideal. Instead, I argue, Plato provides several different portraits of godlikeness that together suggest interest in particulars makes the person neither better nor worse as a philosopher
The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model
No full textPublished by Oxford University Press on behalf of Sleep Research Society (SRS) 2019. Insomnia-related sleep disruption can contribute to impaired learning and memory. Treatment of insomnia should ideally improve the sleep profile while minimally affecting mnemonic function, yet many hypnotic drugs (e.g. benzodiazepines) are known to impair memory. Here, we used a rat model of insomnia to determine whether the novel hypnotic drug DORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory. Animals were first trained to remember the location of a hidden platform (acquisition) in the Morris Water Maze and then administered DORA-22 (10, 30, or 100 mg/kg doses) or vehicle control. Animals were then subjected to a rodent insomnia model involving two exposures to dirty cages over a 6-hr time period (at time points 0 and 3 hr), followed immediately by a probe trial in which memory of the water maze platform location was evaluated. DORA-22 treatment improved the insomnia-related sleep disruption-wake was attenuated and NREM sleep was normalized. REM sleep amounts were enhanced compared with vehicle treatment for one dose (30 mg/kg). In the first hour of insomnia model exposure, DORA-22 promoted the number and average duration of NREM sleep spindles, which have been previously proposed to play a role in memory consolidation (all doses). Water maze measures revealed probe trial performance improvement for select doses of DORA-22, including increased time spent in the platform quadrant (10 and 30 mg/kg) and time spent in platform location and number of platform crossings (10 mg/kg only). In conclusion, DORA-22 treatment improved insomnia-related sleep disruption and memory consolidation deficits
Donahue Hall from the Quad
No full textDonahue Hall from the Clock on the quad during the fall of 2020.https://soar.stonehill.edu/stonehillcampus_images/1111/thumbnail.jp
Fall Trees
No full textA wide view of the walkway going towards Donahue Hall during the fall of 2020.https://soar.stonehill.edu/stonehillcampus_images/1128/thumbnail.jp
A Tree on the Hill
No full textA tree on the hill in front of Donahue Hall during the fall of 2020.https://soar.stonehill.edu/stonehillcampus_images/1119/thumbnail.jp
Donahue Hall Up Close
No full textA wide angle, close up photo of the front exterior of Donahue Hall during the fall of 2020.https://soar.stonehill.edu/stonehillcampus_images/1107/thumbnail.jp
Leaves Around Donahue Hall
No full textFalling leaves surround Donahue Hall during the fall of 2020.https://soar.stonehill.edu/stonehillcampus_images/1106/thumbnail.jp
Fruit Bowl
No full textA decorative fruit bowl that sits by one of the fireplaces in the main room in Donahue Hall.https://soar.stonehill.edu/stonehillcampus_images/1087/thumbnail.jp
Take a Look
No full textLooking at the main room in Donahue from the Irish Studies Library.https://soar.stonehill.edu/stonehillcampus_images/1086/thumbnail.jp
Meehan Reflection
No full textA reflection of Meehan School of Business building in a puddle.https://soar.stonehill.edu/stonehillcampus_images/1097/thumbnail.jp