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距骨壊死に対するアルミナセラミック性人工距骨置換術のSAFE-Qを用いた臨床成績
Get PDFBackground: The purpose of this retrospective review was to evaluate the clinical outcomes
of patients who underwent total talar replacement for talar necrosis using the SAFE-Q score, which was hypothesized to improve postoperatively. Methods: The study included 24 ankles of 22 patients who underwent total talar replacement from 2012 to 2018 and were evaluated using SAFE-Q preoperatively and postoperatively. Statistical analysis was performed using the mean values of the SAFE-Q and JSSF scale scores, and the range of ankle motion was compared before and 3 years after the surgery using the Wilcoxon signed-rank test. Results: The SAFE-Q scores improved postoperatively in the all the subcategories. “Pain and Pain-Related” changed from a mean value of 42.2±23.9 points preoperatively to a mean value of 84.6±12.6 points postoperatively (p<.01); “Physical Functioning and Daily Living” changed from 36.3±25.2 points to 73.4±20.5 points (p<.01); “Social Functioning” changed from 34.1±34.8 points to 81.0±25.3 points (p<.01); “Shoe-Related” changed from 41.3±28.9 points to 75.4±22.3 points (p<.01); “General Health and Well-Being” changed from 36.7±32.1 to 76.9±29.3 points (p<.01). Conclusion: Twenty-four osteonecrotic tali of 22 patients treated with alumina ceramic total talar replacement achieved good clinical results, as evaluated using the JSSF ankle/hindfoot score and SAFE-Q. Alumina ceramic total talar replacement is the mainstream treatment for talar osteonecrosis.博士（医学）・甲第856号・令和4年12月22
【Original Articles】CLINICAL RESULTS AFTER TOTAL TALAR REPLACEMENT WITH ALUMINA CERAMIC PROSTHESIS EVALUATED USING SAFE-Q FOR OSTEONECROSIS OF THE TALUS
No full textBackground: The purpose of this retrospective review was to evaluate the clinical outcomes of patients who underwent total talar replacement for talar necrosis using the SAFE-Q score, which was hypothesized to improve postoperatively.
Methods: The study included 24 ankles of 22 patients who underwent total talar replacement from 2012 to 2018 and were evaluated using SAFE-Q preoperatively and postoperatively.Statistical analysis was performed using the mean values of the SAFE-Q and JSSF scale scores, and the range of ankle motion was compared before and 3 years after the surgery using the Wilcoxon signed-rank test.
Results: The SAFE-Q scores improved postoperatively in all the subcategories.“Pain and Pain-Related" changed from a mean value of 42.2 ± 23.9 points preoperatively to a mean value of 84.6 ± 12.6 points postoperatively (p<.01);“Physical Functioning and Daily Living" changed from 36.3 ± 25.2 points to 73.4 ± 20.5 points (p<.01);“Social Functioning" changed from 34.1 ± 34.8 points to 81.0 ± 25.3 points (p<.01):“Shoe-Related"changed from 41.3 ± 28.9 points to 75.4 ± 22.3 points (p<.Ol); and "General Health and Well-Being" changed from 36.7 ± 32.1 to 76.9 ± 29.3 points (p<.01).
Conclusion: Tenty-four osteonecrotic tali of 22 patients treated with alumina ceramic total talar replacement achieved good clinical results，as evaluated using the JSSF ankle/hindfoot score and SAFE-Q.Alumina ceramic total talar replacement is the mainstream treatment for talar osteonecrosis.
Level of Evidence: Level Ⅳ, retrospective comparative study
C9orf72由来のプロリン : アルギニンポリペプチドは細胞骨格とメカニカルストレス応答を制御する
Get PDFProline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA) formation. Here, we show that changes to the cytoskeleton and FA by PR poly-dipeptides result in the alteration of cell stiffness and mechanical stress response. PR poly-dipeptides increased the junctions and branches of the IF network and increased cell stiffness. They also changed the distribution of actin filaments and increased the size of FA and intracellular calcium concentration. PR poly-dipeptides or an inhibitor of IF organization prevented cell detachment. Furthermore, PR poly-dipeptides induced upregulation of mechanical stress response factors and led to a maladaptive response to cyclic stretch. These results suggest that the effects of PR poly-dipeptides on mechanical properties and mechanical stress response may serve as a pathogenesis of C9orf72-related neurodegeneration.博士（医学）・甲第846号・令和4年9月28日Copyright © 2022 Shiota, Nagata, Kikuchi, Nanaura, Matsubayashi, Nakanishi,Kobashigawa, Isozumi, Kiriyama, Nagayama, Sugie, Yamashiro and Mori. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
CNS WHO Grade 2 および Grade 3 髄膜腫における、MTAP免疫組織化学とFISH解析によるCDKN2Aコピー数および臨床病理学的特徴との相関性
Get PDFCDKN2A homozygous deletion has occasionally been reported in atypical and anaplastic meningiomas and is considered as one of the genetic alterations commonly involved in their recurrence and malignant progression. Methylthioadenosine phosphorylase (MTAP) immunohistochemistry is a promising surrogate marker for CDKN2A homozygous deletion in different cancers but has not been examined in meningiomas. We performed CDKN2A FISH and MTAP immunohistochemistry on specimens from 30 patients with CNS WHO grade 2 (n = 27) and 3 (n = 3) meningiomas, including specimens from primary and recurrent tumors and then determined whether MTAP immunohistochemistry correlated with CDKN2A homozygous deletion and clinicopathological features. CDKN2A homozygous deletion was detected in 12% (3/26) of CNS WHO grade 2 and 67% (2/3) of CNS WHO grade 3 meningiomas; 3 cases exhibited temporal and/or spatial heterogeneity. MTAP loss was in excellent concordance with CDKN2A homozygous deletion (sensitivity; 100%, specificity; 100%). MTAP loss/CDKN2A homozygous deletion correlated with cellular proliferation (mitotic rate; p = 0.001, Ki-67 labeling index; p = 0.03) and poor prognosis (overall survival; p = 0.01, progression free survival; p < 0.001). Thus, MTAP immunostaining can be a surrogate marker for CDKN2A homozygous deletion in meningiomas, and MTAP loss/CDKN2A homozygous deletion may be an important prognostic factor for meningiomas.博士（医学）・甲第840号・令和4年3月15日© 2021 American Association of Neuropathologists, Inc. All rights reserved.This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of neuropathology and experimental neurology following peer review. The version of record "Vol.81 issue 2 p.117-126 (2022 Jan 29)" is available online at: https://doi.org/10.1093/jnen/nlab127