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DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line
No full textWhile carbon-based materials have spearheaded numerous breakthroughs in
biomedicine, they also have procreated many logical concerns on their
overall toxicity. Carbon dots (CDs) as a respectively new member have
been extensively explored in nucleus directed delivery and bioimaging
due to their intrinsic fluorescence properties coupled with their small
size and surface properties. Although various in vitro/in vivo studies
have shown that CDs are mostly biocompatible, sufficient information is
lacking regarding genotoxicity of them and underlying mechanisms. This
study aims to analyze the real-time cytotoxicity of super tiny CDs (2.05
+/- 0.22 nm) on human breast cancer cells (MCF7) and human primary
dermal fibroblast cell cultures (HDFa) by xCELLigence analysis system
for further evaluating their genotoxicity and clastogenicity to evaluate
the anti-tumor potential of CDs on breast adenocarcinoma. As combined
with flow cytometry studies, comet assay and cytokinesis-block
micronucleus assay suggest that the CDs can penetrate to the cell
nuclei, interact with the genetic material, and explode DNA damage and
G0/G1 phase arrest in cancer cells even at very low concentrations
(0.025 ppm) which provide a strong foundation for the design of
potentially promising CD-based functional nanomaterials for DNA-damage
induced treatment in cancer therapy
The Extension of the Massless Fermion Behaviour in the Cosmic String Spacetime
No full textIn this work, we have obtained the solutions of a massless fermion which
is under the external magnetic field around a cosmic string for specific
three potential models using supersymmetric quantum mechanics. The
constant magnetic field, energy-dependent potentials, and
position-dependent mass models are investigated for the Dirac
Hamiltonians, and an extension of these three potential models and their
solutions is also obtained. The energy spectrum and potential graphs for
each case are discussed for the alpha deficit angle
Transüretral Rezeksiyon Yapılan Yaşlı Hastalarda Spinal Anestezi için Optimal İzobarik Bupivakain Dozu Nedir?
No full textGebelerin Dünya Sağlık Örgütü’nün Pozitif Gebelik Deneyimi İçin Tavsiye Ettiği Rutin Doğum Öncesi Bakımı Alma Durumlarının Değerlendirilmesi
No full textImpact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group
No full textLactobacillus reuteri dsm 17938 and quality of life associated with functional constipation [Lactobacillus reuteri dsm 17938 in kakovost življenja, povezana s funkcionalnim zaprtjem]
No full textÇOCUK ALGI ÖLÇEĞİNİN(CPQ8-10) TÜRKÇE ÇEVİRİSİNİN PEDODONTİ KLİNİĞİNDE GEÇERLİLİĞİNİN DEĞERLENDİRİLMESİ
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