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Antidepressant potential of lotus corniculatus L. subsp. corniculatus: An ethnobotany based approach
No full text
Investıgatıon And Optımızatıon Of The Effect Of Cuttıng Condıtıons And Cuttıng Tool Coatıng Type In Borıng Operatıon
No full textBileşenler üzerindeki delikler çoğu durumda montaj amaçları için gerekli olduğundan, delik
delme süreçleri ile üretilen delikler çok dikkat gerektiren son derece önemli işlemlerdir. Bir
plaka veya yüzey üzerine deliklerin hassas bir şekilde delinmesi, bu amaç için tasarlanmış,
delik işleme tezgâhlarında matkap, rayba veya delik kateri denilen takımlar kullanılarak
yapılır. Tolerans sınırı içerisinde olmasına rağmen, deliklerin yanlış geometrisi nedeniyle
montaj sorunları ortaya çıkabilir. Ölçü bozukluğu, silindiriklik, dairesellik, pozisyon hataları
gibi çeşitli boyutsal ve geometrik toleranslar bu tür montaj problemlerine neden olmaktadır.
Bu araştırma, Al7050 T7451 alüminyum alaşımlı plaka malzemede önceden delinmiş
deliklerin 12 mm çap ölçüsüne işlenmesiyle oluşturulan deliklerin boyutsal tamlığı,
daireselliği, silindirikliği ve yüzey kalitesi üzerine delik işleme (veya baralama)
parametrelerinin etkilerini belirleme üzerine yapılmıştır. Deneyler, kuru ve ıslak işleme
koşulları altında hassas delik işleme kafası kullanılarak hassas delik delme tezgâhında
gerçekleştirilmiştir. Deliklerin işlenmesinde iki farklı özelliğe sahip CCGT 060202 26G6 ve
CCGT 060202F-AL KX kesici uçlar kullanılmıştır. Bu çalışmada, kesici uç tipi, soğutma
sıvısı kullanımı, iş mili hızı (dev/dak) ve ilerleme oranı (inch/dev) delik işleme parametreleri
olarak seçilmiştir. İş mili hızı ve ilerleme oranı üçer seviye, kesici uç ve kesme şartları iki
seviyeye sahip olup, deney planı Taguchi L9(32) orthogonal düzene göre oluşturulmuştur.
Dikkate alınan delik boyutsal tamlığı, daireselliği, silindirikliği ve yüzey kalitesi gibi kalite
karakteristiklerinin her biri için ayrı analiz yapılmıştır. Ayrıca, işleme parametrelerinin her
bir kalite karakteristiğine olan katkı oranını belirlemek için de Pareto ANOVA yöntemi
uygulanmıştır. Bütün kalite karakteristikleri için en uygun kombinasyonlar bu sonuçlar
ışığında elde edilmiştirSince the holes on the components are in most cases necessary for mounting purposes, the
holes produced by drilling processes are extremely important processes that require a lot of
attention. Precise drilling of holes on a plate or surface is done by using jig borer designed
for this purpose by using tools called drill, reamer or boring tool. Though the tolerance is
within limit, assembly problems could arise due to the improper geometry of these holes.
Various dimensional and geometrical tolerances like cylindricity, circularity and position
errors are responsible for such assembly problems. This research studied on determining the
effects of boring parameters on the dimensional accuracy, circularity, cylindricity and
surface quality of the hole produced by boring to 12 mm the diameter of the holes predrilled
on AL 7050 T7451 aluminium alloy plate material. Experiments were carried out on a
precision boring machine using a precise boring head under dry and wet machining
conditions. CCGT 060202 26G6 and CCGT 060202F-AL KX inserts have two different
quality features have been used for boring of the holes. In this study, insert type, using
coolant, spindle speed (rpm) feed rate (inch/rev) has been selected as boring parameters.
Spindle speed and feed rate have three levels, insert and cutting condition have two levels,
and experimental plan has been created according to Taguchi L9(32) orthogonal array.
Separate analyzes were made for each of the quality characteristics such as hole dimensional
integrity, circularity, cylindricity and surface quality considered. In addition, Pareto
ANOVA method was applied to determine the contribution rate of processing parameters to
each quality characteristic. Optimum combinations for all quality characteristics are
obtained in the light of these results.
Scienc
Biosorption, isotherm and kinetic properties of common textile dye by phormidium animale
No full textSynthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells
No full textNovel 3(2H)-pyridazinone derivatives were designed, synthesised in
satisfactory yields and evaluated in different experimental assays to
assess their preliminary toxicity in vivo and anti-proliferative effects
against HCT116 cell lines in vitro. Artemia salina lethality test
provided LC50 values >100 mu g/mL for all compounds. Successive assays
revealed that some compounds were endowed with a promising
anti-proliferative effect against HCT116 cells, alone or stimulated by
serotonin as a pro-inflammatory factor in order to mimick an inflamed
model in vivo of cancer cell microenvironment. Moreover, the kinurenic
acid level after treatment with these newly synthesised compounds was
monitored as a marker of anti-proliferation in colon carcinoma models.
The IC50 values obtained for the best-in-class compounds were comparable
to that of daunorubicin as a reference drug. Conversely, these compounds
were not able to counteract the spontaneous migration of human cancer
HCT116 cell line in the wound healing paradigm
Outcomes of Eltrombopag Treatment and Development of Iron Deficiency in Children with Immune Thrombocytopenia in Turkey
No full textObjective: Immune thrombocytopenia (ITP) is a rare autoimmune disease
and hematologic disorder characterized by reduced platelet counts that
can result in significant symptoms, such as bleeding, bruising,
epistaxis, or petechiae. The thrombopoietin receptor agonist eltrombopag
(EPAG) is a second-line agent used to treat chronic ITP purpura in
adults and children.
Materials and Methods: The present retrospective study evaluated the
efficacy, safety, and side effects of EPAG treatment in pediatric
patients with acute refractory and chronic immune thrombocytopenia,
particularly focusing on iron-deficiency anemia.
Results: The diagnosis was chronic ITP in 89 patients and acute
refractory ITP in 16 patients. The mean age of patients was 9.5 +/- 4.5
years (minimum-maximum: 1.2-18 years) at the beginning of EPAG
treatment. The overall response rate was 74.3\% (n=78). The mean time
for platelet count of >= 50x109/L was 11.6 +/- 8 weeks (range: 1-34
weeks). The treatment was stopped for 27 patients (25.7\%) at an average
of 6.8 +/- 9 months (range: 1-38 months). The reason for discontinuation
was lack of response in 18 patients, nonadherence in 4 patients, and
hepatotoxicity in 2 patients. Response to treatment continued for an
average of 4 months after cessation of EPAG in 3 patients.
Conclusion: Results of the current study imply that EPAG is an effective
therapeutic option in pediatric patients with acute refractory and
chronic ITP. However, patients must be closely monitored for response
and side effects during treatment, and especially for iron deficiency
Goal programming model for production-distribution planning by considering carbon emission
No full textControl of pre and post transmission parallel hybrid vehicles with fuzzy logic method an comparison with other power systems
No full textIn this study, modeling of pre-transmission parallel hybrid, post-
transmission parallel hybrid, serial hybrid and conventional vehicle
structures in Matlab / SIMULINK environment. Average fuel consumption
values for different driving cycles were obtained on the vehicle models
created and compared. The power, gear range and regenerative brake
control of the parallel hybrid vehicle were provided by the control
algorithm developed by the fuzzy logic method. Transfer functions
representing the vehicle's power system have been created for all
vehicle structures. Rolling, acceleration and aerodynamic forces acting
on the vehicle are included in the model. The torque / speed and
specific fuel consumption map of the 1.8 liter ``ZR-FXE{''} gasoline
engine was used in the internal combustion engine model. In the electric
motor model, the torque / speed and efficiency map of the ``Ashwoods /
Elmo-D576{''} brand electric motor was used. A 7-speed DCT transmission
is used in all vehicle structures. The vehicle uses a 5 kWh energy
capacity, hum ion battery pack. The battery model was created with the
equivalent circuit method Rint method. It was determined that the lowest
average fuel consumption values for US06, FTP75, NEDC, EUDC driving
cycles were obtained as 5.73, 4, 3.96 and 4.18 L / 100 km with the
pre-transmission parallel hybrid vehicle structure controlled by fuzzy
logic method. In the ECE15 driving cycle, it was determined that the
serial hybrid vehicle structure has the lowest average fuel consumption
with a value of 3.62 L / 100 km. In the ECE15 driving cycle, where
regenerative braking use is most effective, it has been observed that
the series, pretransmission parallel and post transmission parallel
hybrid vehicle structures save 14.22\%, 11.5\% and 9.95\% respectively