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European Society of Gynaecological Oncology quality indicators for surgical treatment of cervical cancer
No full text
The prognostic role of neopterin in COVID-19 patients
No full textIn Coronavirus disease-2019 (COVID-19) cases, hyper inflammation is
associated with the severity of the disease. High levels of circulating
cytokines were reported in severe COVID-19 patients. Neopterin produced
by macrophages on stimulation with interferon-gamma, which is an
important cytokine in the antiviral immune response, hence it can be
used to predict the severity of disease in COVID-19 cases. In this
study, it was aimed to determine the prognostic value of the neopterin
for the prediction of severe disease in patients with COVID-19. This
single-center, prospective study was conducted in hospitalized COVID-19
patients and healthy volunteers. Severe and mild COVID-19 cases were
compared in terms of clinical and laboratory findings as well as serum
neopterin levels on hospital admission. To assess the prognostic utility
of neopterin between the severe and mild COVID-19 groups, a
receiver-operating characteristic (ROC) curve was generated, and the
area under the curve (AUC) was calculated. The median serum neopterin
level was four times higher in COVID-19 patients than the healthy
controls (46 vs. 12 nmol/L;p < .001). The AUC value of serum neopterin
was 0.914 (95\% confidence interval, 0.85-0.97). The sensitivity and
specificity of serum neopterin for the cut-off value of 90 nmol/L to
identify severe COVID-19 cases were 100\% and 76\%, respectively. Serum
neopterin levels on hospitalization were significantly higher in severe
COVID-19 disease than mild COVID-19 patients. Neopterin levels can be
used as an early prognostic biomarker for COVID-19 on admission
A Comparative Performance Investigation of Swarm Optimisers on the Design of Hydrostatic Thrust Bearing
No full textIn the design of hydrostatic thrust bearings, power loss that occurs
during operation is an important parameter that affects the design, and
due to such features, it falls within the interest of design
optimisation studies. The fact that the decimal places of the
constraints and design variables used for minimum power loss
optimisation of hydrostatic thrust bearings are highly effective on the
result is a challenge for the design optimisation studies carried out on
the problem and has yet made it rather attractive for the researchers.
In this study, it is this feature of the problem that makes it the most
important motivator in researching the performance of different
metaheuristic optimisers in solving the minimum power loss problem. To
this end, 7 different optimisers, four of them for the first time, were
applied under equal conditions with various pop sizes and a number of
iterations, and their performances were addressed under this challenging
benchmark problem. The performances of these methods were compared to
each other. In addition to the success of optimisers in reaching a
solution, their performance in different populations and iterations is
also discussed in the study. Considering the results, it is seen that
MVO is the most effective optimiser in solving the problem and is
followed by the WOA, PSO, and GWO. The application of WOA, MVO, CS, and
SSA, for the first time, on the problem has exhibited that these methods
could be used in optimisation of such delicate engineering problems
Added Value of Contrast Medium in Whole-Body Hybrid Positron Emission Tomography/Magnetic Resonance Imaging: Comparison between Contrast-Enhanced and Non-Contrast-Enhanced Protocols.
No full textTo compare the diagnostic ability and time efficiency of contrast-enhanced (CE) whole body fluorodeoxyglucose (FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) protocol and non-CE (NCE) protocol
Aralıklı Açlık Uygulamalarının Vücut Bileşimi ve Biyokimyasal Parametreler Üzerine Etkisi: Bir Literatür Derlemesi
No full textEnzyme inhibitory assessment of the isolated constituents from Plantago holosteum Scop.
No full textPlants of the Plantago genus are widely used in Turkish folk medicine
especially for the treatment of wound, abscess, and inflammation. The
aqueous extract and five phenylethanoid glycosides acteoside (1),
arenarioside (2), echinacoside (3), isoacteoside (4), and
leucosceptoside A (5) isolated from the aerial parts and roots of
Plantago holosteum Scop. (Plantaginaceae) were tested for their possible
inhibitory activity against hyaluronidase, elastase, and collagenase,
related to wound pathogenesis. Even though the aqueous extract prepared
from the aerial parts (36.26\%) and roots (47.01\%) and the isolated
compounds acteoside (29.13\%), echinacoside (28.73\%), and isoacteoside
(31.69\%) exerted a notable inhibition, arenarioside and leucosceptoside
A were found inactive in the hyaluronidase enzyme inhibition test.
Similar results were obtained from the collagenase enzyme inhibition
test. The aqueous extract prepared from the aerial parts (31.09\%) and
roots (35.17\%), echinacoside (25.13\%), and isoacteoside (23.85\%)
exerted a notable inhibition in this test. However, none of the extracts
and isolated compounds displayed elastase enzyme inhibitory activity.
The experimental data demonstrated that P. holosteum displayed a
remarkable enzyme inhibitory activity against hyaluronidase and
collagenase. This paper is the first report regarding the in vitro
enzyme inhibitory activity of P. holosteum