Gazi University Dspace
Not a member yet
26981 research outputs found
Sort by
Investigation of the Effect of Hydrothermal Waters on Radionuclide Activity Concentrations in Natural Marble with Multivariate Statistical Analysis
No full textThe study aims to investigate the effects of Burdur (Turkey) marble on
human health by interpreting their radioactivity concentration
(Ra-226,Th-232, and(40)K), radiological hazard parameters, chemical
concentration, physical properties, and all data related to these
features by using multivariate statistical methods. Chemical and
radionuclide analyses were performed on marble samples. The data were
interpreted by statistical analysis. According to the regression model,
an increase in the concentration of vanadium carried to the environment
by hydrothermal waters causes a 4.452-fold higher concentration
of(226)Ra. The R(2)value of the model was 0.64 and it was statistically
significant. The maximum concentration of(226)Ra in Isparta Davraz Beige
sample (M7) exceeded the values of some countries' standards. Except for
M7, the analyzed sorts of marble can be used safely in dwellings and
public buildings
The addition of an amylopectin/chromium complex to branched-chain amino acids enhances muscle protein synthesis in rat skeletal muscle
No full textDetermination of myocardial scar tissue in coronary slow flow phenomenon and the relationship between amount of scar tissue and nt-probnp [Determinação do tecido cicatricial do miocárdio no fenômeno de fluxo coronário lento e a relação entre a quantidade de tecido cicatricial e o nt-probnp]
No full textColchicine intolerance in FMF patients and primary obstacles for optimal dosing
No full textBackground/aim: Colchicine is the mainstay of treatment in FMF. However,
in daily practice it is not easy to maintain effective colchicine doses
in a substantial number of patients due to its side effects. In this
study, we aimed to investigate prevalence and risk factors for
colchicine side effects that limit optimal drug dosing and cause
permanent discontinuation.
Materials and methods: All patients were recruited from ``FMF in Central
Anatolia{''} (FiCA) cohort, 915 adults with a minimum follow-up time of
6 months during which they had obeyed all treatment instructions.
Demographic and anthropometric data, FMF disease characteristics,
disease severity, complications, and treatment features were recorded on
a web-based registry. Prevalence of colchicine intolerance and
characteristics of intolerant patients were analyzed.
Results: Effective colchicine doses cannot be maintained in 172 (18.7\%)
subjects. Main side effects that limit optimal dosing were as follows:
diarrhea in 99 (10.8\%), elevation in transaminases in 54 (5.9\%),
leukopenia in 10 (\%1.1), renal impairment in 14 (1.3\%), myopathy in
five (0.5\%), and allergic skin reaction in two. Colchicine had to be
permanently ceased in 18 (2\%) patients because of serious toxicity.
Male sex and obesity were found to be associated with liver toxicity,
and having a normal body weight was associated with diarrhea. Chronic
inflammation and proteinuria were more common in colchicine-intolerant
patients, and they had reported more frequent attacks compared to those
tolerating optimal doses.
Conclusion: Colchicine intolerance is an important problem in daily
clinical practice, mainly due to diarrhea and liver toxicity. Suboptimal
colchicine dosing is associated with complications
SURFACE MICROHARDNESS AND ROUGHNESS PROPERTIES OF BIODENTINE FOLLOWING TREATMENT WITH VARIOUS ENDODONTIC IRRIGANTS
No full text
Ellagic Acid Enhances Antitumor Efficacy of Temozolomide in an in vitro Glioblastoma Model
No full textInfluence of aluminum salts on COVID-19 infected patients
No full textBackground/aim: Based on the antiviral and antibacterial properties of
aluminum salts, we aimed to find out the influence of aluminum salts on
COVID-19 infected patients.
Materials and methods: We performed an observational retrospective
cohort study which includes the patients diagnosed as COVID-19 and
received aluminum salts in addition to actual treatments during
hospitalization as the treatment group (Alum Group). Patients who
received standard COVID-19 treatment protocols in the Infectious
Diseases Clinics were included as the Control Group. Clinical findings,
laboratory parameters, length of stay, survival, radiological follow-up,
intensive care and mechanical ventilation needs, the presence of
comorbidity, polymerase chain reaction (PCR) tests, symptoms, symptom
recovery times, hospital stay times, treatment protocols, and clinical
presence of pneumonia were examined in all patients. Advanced chemical
composition analyzes of existing aluminum salts were also performed.
Results: A total of 109 patients, 54 in the alum group and 55 in the
control group, were included in the study. None of the patients in the
aluminum group developed side effects due to the intake of aluminum
salt. Survival status was significantly different between the two groups
as there were 5 loss in the Control Group and none in the Alum Group (P
= 0.023). The symptom recovery time was significantly shorter in the
Alum Group; 2 (1-3) vs. 1 (1-2) days, P= 0.003. According to the paired
samples analyses of the comparison between hospitalization and
discharge, CRP levels significantly drops in the Alum Group (from 54.09
to 27, P = 0.001) but not in the Control Group. The drop was
significantly same for the lactate dehydrogenase (LDH) and procalcitonin
levels with P = 0.001.
Conclusion: It has been observed that aluminum salts have beneficial
effects in COVID-19 infected cases. Considering the low systemic
toxicity of intermittent oral intake of aluminum salts as food
supplements and the fact that pandemic control is still not achieved,
the use of aluminum salts is promising