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Prevalence of diversified antibiotic resistant bacteria within sanitation related facilities of human populated workplaces in abbottabad
No full textHighly luminescent water-dispersed silicon quantum dots for fluorometric determination of oxytetracycline in milk samples
No full textIgG4-related disease: a contemporary review
No full textBackground/aim: Immunoglobulin G4-related disease (IgG4-RD), is an
immune-mediated fibroinflammatory condition, which may involve multiple
organs and mostly presents with high serum IgG4 levels and specific
histopathological characteristics. As IgG4-RD is a relatively new entity
the etiology, prevalence and epidemiologic knowledge is quite limited.
Although involvement of almost all anatomical regions has been reported,
the most commonly affected regions are pancreas, lacrimal glands,
salivary glands, retroperitoneum, orbita, lymph nodes, kidney and lungs.
Diagnosis is made with combined evaluation of clinical, radiological and
histopathological findings. Typical histopathological features include
storiform fibrosis, dense lymphoplasmacytic infiltrates and obliterative
phlebitis. Its course is typically marked by remission and relapsing
attacks and it may lead to fibrosis, destructive lesions in tissues and
organ failure unless promptly treated. In the treatment of IgG4-RD, many
approaches including surgical resection of tissues, systemic
glucocorticoids, steroid-sparing immunosuppressive drugs, and biological
agents are employed. Although association is not clear, malignancies are
frequently reported in IgG4-RD patients. Therefore, it is prudent to
monitor patients for the symptoms of malignant diseases.
Conclusion: In this review, recent advances in clinico-pathological
characteristics, diagnosis, and treatment of IgG4-RD are discussed
Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey
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