Erciyes University - AVESIS
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ORTAOKUL ÖĞRENCİLERİNİN BOYUT KONUSUNDA MATEMATİKSEL KAVRAMLARA YÜKLEDİĞİ MANALAR İLE MATEMATİKSEL DİLİ KULLANABİLME BECERİLERİNİN İNCELENMESİ
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The effect of pituitary neuroendocrine tumors on the volumes of intracranial structures
No full textObjective: Pituitary Neuroendocrine Tumors (PitNETs) can cause symptoms via mass effect or hormonal imbalances. This study investigated whether PitNETs induce volumetric changes in intracranial structures and assessed the diagnostic potential of these changes. Materials and methods: A retrospective analysis was conducted on 90 PitNET patients and 86 healthy controls. MRI data, acquired on a 1.5 Tesla scanner, were processed using the automated Vol2Brain system to calculate relative brain volumes. Results: PitNET patients exhibited significantly lower relative volumes across numerous brain structures compared to controls. This included reduced intracranial, cerebral, and cortical gray matter (GM), as well as temporal lobe, vermis, limbic lobe, hippocampus, and inferior lateral ventricle (ILV) volumes. Gyrus-level analysis also revealed significantly smaller volumes in key regions like the posterior orbital gyrus, supplementary motor cortex, and entorhinal area in PitNET patients. ROC analysis demonstrated good to very good diagnostic performance for ILV volume (AUC = 0.863; p = 0.002) and subcortical GM volume (AUC = 0.725; p = 0.049) in differentiating groups. Reduced volumes were also noted in basal ganglia structures. Conclusion: Our findings indicate significant volumetric reductions in various brain regions in PitNET patients, potentially explaining observed emotional and cognitive symptoms. The diagnostic utility of ILV and subcortical GM volumes is promising, suggesting their value as diagnostic adjuncts. These objective volumetric assessments may assist in surgical planning and patient stratification, though further prospective research is warranted to establish direct links with clinical outcomes
Formation of Colchicine-incorporated Hybrid Nanoflower With an Intrinsic Peroxidase-Mimic and Enhanced Antimicrobial Activities
No full textWe report the formation of colchicine-Cu-3(PO4)(2) hybrid nanoflowers (Colc-NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H2O2). While the colchicine molecule, known as a secondary metabolite with anti-inflammatory properties, was used as an organic part of Colc-NFs, the Cu2+ ion acted as an inorganic part of Colc-NFs. The acetamide group in the colchicine structure may react with Cu2+ ions in phosphate-buffered saline to form Colc-NFs. The Colc-NFs exhibited both an intrinsic peroxidase-mimic activity against guaiacol and antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Candida albicans in the presence of H2O2. Both activities of the Colc-NFs rely on a Fenton-like reaction mechanism by producing reactive hydroxyl radicals. In addition to that high surface-to-volume ratio and porous structure of Colc-NFs may contribute to their peroxidase-mimic activities depending on the Fenton-like reaction
Multifunctional Cyclic Olefin Copolymer-Titanium Dioxide-Based Nanocomposites for Enhanced Antibacterial and Biocompatible Properties
No full textThe growing demand for multifunctional materials in biomedical and packaging applications necessitates the development of advanced nanocomposites with superior mechanical, barrier, and antibacterial properties. This study presents cyclic olefin copolymer (COC)/titanium dioxide (TiO2) nanocomposite films fabricated through the facile solution casting method, incorporating TiO2 at concentrations of 1, 3, and 5 wt %. Structural and morphological analyses confirmed effective TiO2 dispersion at lower concentrations, while agglomeration was observed at 5 wt %. The incorporation of TiO2 significantly enhanced barrier properties, reducing water vapor permeability from 80.67 to 29.99 g/m2 h and oxygen permeability from 7.66 to 2.78 mg/mL. Mechanical properties showed marked improvement, with tensile strength increasing by 113% and tensile modulus by 81.3% at 3 wt % TiO2. Antibacterial tests demonstrated efficacy against Escherichia coli and Staphylococcus aureus, while cytotoxicity studies confirmed the biocompatibility of the films. These findings highlight the potential of COC/TiO2 nanocomposites for applications, such as antibacterial coatings, wound healing patches, and high-performance packaging
Exploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach
No full textGastrointestinal parasite (GIP) infections are a major challenge in pasture-based sheep farming, leading to both economic losses and animal welfare concerns. This study aimed to identify genetic factors that contribute to resistance against tapeworm (Moniezia spp.) infections in Central Anatolian Merino (CAM) sheep. We conducted genome-wide association studies (GWAS) on 226 CAM lambs, analyzing their genetic data in relation to Moniezia spp. egg burden. Thirteen significant genetic markers (SNPs) were identified. Two key immune-related genes, CD79A and MAP3K7, were linked to parasite resistance. CD79A is essential for B-cell activation and antibody production, while MAP3K7 regulates immune responses, particularly through NF-κB signaling. These findings highlight the potential for using genetic information to improve disease resistance in livestock breeding programs. Further research is needed to understand the role of these genes and to explore host–parasite interactions in more detail
Comparison of tear cytokines and neuropeptides, ocular surface parameters, and corneal nerve structure in patients with early-stage diabetes mellitus and control subjects
No full textPurposeThis study aimed to assess the impact of diabetes mellitus (DM) on the corneal nerve, ocular surface, and tear cytokine and substance P (SP) levels and to compare the findings with those in control subjects.MethodsThis cross-sectional study included 23 patients diagnosed with DM within the last 5 years and who had no systemic involvement, including diabetic retinopathy, and 22 control subjects. The ocular surface and tear film were assessed using the Ocular Surface Disease Index (OSDI) questionnaire, ocular surface staining, Schirmer, and corneal sensitivity. In vivo confocal microscopy was used to assess the architecture of the corneal nerves. The tear levels of cytokines were examined by Luminex and SP levels were measured by ELISA.ResultsBoth groups had similar OSDI scores, ocular surface staining, Schirmer, and corneal sensitivity measurements. The patient group had higher corneal nerve tortuosity (p = 0.015) but showed no significant difference in short or long nerve fibre density compared with the control group. Tear IL-6 and IL-8 levels were higher in the DM group (p = 0.002 and p = 0.01, respectively), whereas tear SP levels were lower in the DM group (p = 0.05). The tear SP level exhibited a strong positive correlation with total and long nerve fibre parameters (both p = 0.00).ConclusionsThe study results indicated that DM affected corneal nerve structure, tear SP, and inflammatory cytokine levels. The corneal nerves were affected and the tear SP level decreased even in patients without peripheral neuropathy, which is one of the most common complications of DM. In addition, ocular surface inflammation was observed in patients with DM, despite no ocular surface symptoms