Erciyes University - AVESIS
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Early Prediction of Construction Disputes: Decision Support Systems with Machine Learning Techniques
No full textFinancial Stress, Lithium Prices, and Renewable Energy Nexus in Times of Geopolitical Crisis: A Time-Frequency Analysis
No full textA Rare Craniosynostosis Phenotype Associated With a Homozygous CYP26B1 Pathogenic Variant in the Absence of Extremity Synostosis
No full textCYP26B1, a member of the cytochrome P450 enzyme family, is one of the enzymes responsible for the inactivation of retinoic acid. Pathogenic variants in genes involved in endogenous retinoic acid production and control can result in craniofacial disorders and extremity abnormalities. The patient was referred due to craniosynostosis and dysmorphic appearance at the age of 3 years. Clinical exome sequencing showed a likely pathogenic homozygous missense variant, c.1190G>A (p.Arg397Gln), in exon 5 of the CYP26B1 gene. Nine cases with craniosynostosis, various skeletal deformities, arachnodactyly, and encephalocele have been reported in the literature so far, caused by biallelic pathogenic variants in the CYP26B1. All patients had a fusion of various bones in the upper extremity, in addition to premature closure of the skull sutures. Although our patient had craniosynostosis, there was no additional obvious joint synostosis. Herein, we describe a case of an extremely rare skeletal disorder caused by a pathogenic variant in CYP26B1. We broaden the phenotypic spectrum and underscore that extremity joint fusions are not a universal finding of the disease
SOSYAL MEDYADA GELİŞMELERİ KAÇIRMA KORKUSU YAŞAYAN BİREYLERDE GÖSTERİŞ TÜKETİMİ VE MANEVİ-İNSANİ DEĞERLER İLİŞKİSİ
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Numerical analysis and experimental comparison of stress and stiffness parameters of steel reinforced geopolymer concrete columns
No full textDespite extensive research, Geopolymer concrete (GPC) lacks reinforced concrete construction and design specifications. Developing such specifications requires comprehensive studies to promote the use of GPC, which is known for its superior performance and environmental benefits compared to ordinary Portland cement concrete (OPC). This study numerically investigated and compared the behavior and strength of fly ash-based geopolymer-reinforced concrete columns with the experimental results. Comparisons with OPC were made based on existing specifications. Herein, FEM analyses were conducted on 16 GPC and 4 OPC columns under eccentric axial compressive loads. Parameters such as eccentricity, reinforcement ratio, curing method, and activation solution ratios were varied. According to average numerical results, the GPC columns have 7% more moment capacity and 30% more curvature values than OPC. Moreover, GPC columns absorbed more energy than OPC columns. Also, GPC columns have higher axial load and bending moment carrying capacities than OPC for numerical results. Error analysis between FEM and experimental data revealed a strong correlation, with MAPE values of 8.88% (axial load) and 7.20% (moment) for GPC columns, confirming the reliability of the numerical model. ACI 318 and Eurocode 2 specifications were deemed applicable for GPC columns, provided axial loads are limited per TEC 2018
